Difference between revisions of "Bevacizumab-awwb (Mvasi)"
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− | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://reference.medscape.com/drug/avastin-bevacizumab-342257 Medscape],[http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information. |
==Diseases for which it is used== | ==Diseases for which it is used== |
Revision as of 16:15, 3 December 2017
Note: this is the first FDA-approved biosimilar. The information below is reproduced from the Bevacizumab (Avastin) page, except for the details of FDA indication.
General information
Class/mechanism: Monoclonal antibody that inhibits angiogenesis by binding VEGF and preventing the interaction of VEGF with its receptors (Flt-1 and KDR) on the surface of endothelial cells.
Route: IV
Extravasation: neutral
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.
Diseases for which it is used
- Breast cancer
- Central nervous system (CNS) cancer
- Cervical cancer
- Colon cancer
- Esophageal cancer
- Follicular lymphoma
- Hepatobiliary cancer
- Melanoma
- Neuroendocrine tumors
- Non-small cell lung cancer
- Ovarian cancer
- Renal cancer
- Soft tissue sarcoma
- Unknown primary
- Uterine cancer
History of changes in FDA indication
- 9/14/2017: FDA approved for the treatment of patients with the following cancers:
- Metastatic colorectal cancer, in combination with intravenous 5-fluorouracil–based chemotherapy for first- or second-line treatment.
- Mvasi is not indicated for the adjuvant treatment of surgically resected colorectal cancer.
- Metastatic colorectal cancer, in combination with fluoropyrimidine-irinotecan- or fluoropyrmidine-oxaliplatin-based chemotherapy for the second-line treatment of patients who have progressed on a first-line bevacizumab product-containing regimen.
- Non-squamous non-small cell lung cancer, in combination with carboplatin and paclitaxel for first line treatment of unresectable, locally advanced, recurrent or metastatic disease.
- Glioblastoma with progressive disease following prior therapy, based on improvement in objective response rate. No data available demonstrating improvement in disease-related symptoms or survival with bevacizumab products.
- Metastatic renal cell carcinoma, in combination with interferon alfa.
- Cervical cancer that is persistent, recurrent, or metastatic disease, in combination with paclitaxel and cisplatin or paclitaxel and topotecan.
- Note: Bevacizumab (Avastin) has a label for ovarian cancer, which was not included in the initial FDA approval for bevacizumab-awwb.
Also known as
- Brand name: Mvasi
- Drug index
- Intravenous medications
- Neutral chemotherapy
- Antibody medications
- Anti-VEGF antibodies
- VEGF inhibitors
- Breast cancer medications
- Cancer of unknown primary medications
- Central nervous system (CNS) cancer medications
- Cervical cancer medications
- Colon cancer medications
- Esophageal cancer medications
- Follicular lymphoma medications
- Hepatobiliary cancer medications
- Melanoma medications
- Neuroendocrine tumor medications
- Non-small cell lung cancer medications
- Ovarian cancer medications
- Renal cancer medications
- Soft tissue sarcoma medications
- Uterine cancer medications
- Drugs FDA approved in 2017
- Biosimilars