Difference between revisions of "Medulloblastoma"
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(Created page with "{| class="wikitable" style="text-align:center; width:50%;" !colspan="2" align="center" style="color:white; font-size:125%; background-color:#4a1486"|'''Section editor''' |- |s...") |
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| + | ====Preceding treatment==== | ||
| + | *Surgery | ||
====Chemotherapy==== | ====Chemotherapy==== | ||
*[[Carboplatin (Paraplatin)]] | *[[Carboplatin (Paraplatin)]] | ||
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===References=== | ===References=== | ||
# Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, Soerensen N, Graf N, Emser A, Pietsch T, Wolff JE, Kortmann RD, Kuehl J. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med. 2005 Mar 10;352(10):978-86. [https://www.nejm.org/doi/10.1056/NEJMoa042176 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/15758008 PubMed] | # Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, Soerensen N, Graf N, Emser A, Pietsch T, Wolff JE, Kortmann RD, Kuehl J. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med. 2005 Mar 10;352(10):978-86. [https://www.nejm.org/doi/10.1056/NEJMoa042176 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/15758008 PubMed] | ||
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| + | ==Cyclophosphamide & Vincristine/Cisplatin & Etoposide {{#subobject:852402|Regimen=1}}== | ||
| + | {| class="wikitable" style="float:right; margin-left: 5px;" | ||
| + | |- | ||
| + | |[[#top|back to top]] | ||
| + | |} | ||
| + | ===Regimen {{#subobject:1a3d99|Variant=1}}=== | ||
| + | {| class="wikitable" style="width: 100%; text-align:center;" | ||
| + | !style="width: 50%"|Study | ||
| + | !style="width: 50%"|[[Levels_of_Evidence#Evidence|Evidence]] | ||
| + | |- | ||
| + | |[https://www.nejm.org/doi/10.1056/NEJM199306173282401 Duffner et al. 1993] | ||
| + | | style="background-color:#91cf61" |Non-randomized | ||
| + | |- | ||
| + | |} | ||
| + | ''Total duration of treatment is 12 to 24 months.'' | ||
| + | ====Preceding treatment==== | ||
| + | *Surgical resection or biopsy | ||
| + | ====Chemotherapy, part 1==== | ||
| + | *[[Cyclophosphamide (Cytoxan)]] | ||
| + | *[[Vincristine (Oncovin)]] | ||
| + | |||
| + | '''28-day cycle for 2 cycles, alternating with part 2''' | ||
| + | |||
| + | ====Chemotherapy, part 2==== | ||
| + | *[[Cisplatin (Platinol)]] | ||
| + | *[[Etoposide (Vepesid)]] | ||
| + | |||
| + | '''28-day cycle for 1 cycle, alternating with part 1''' | ||
| + | |||
| + | ===References=== | ||
| + | # Duffner PK, Horowitz ME, Krischer JP, Friedman HS, Burger PC, Cohen ME, Sanford RA, Mulhern RK, James HE, Freeman CR, Seidel FG, Kun LE. Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med. 1993 Jun 17;328(24):1725-31. [https://www.nejm.org/doi/10.1056/NEJM199306173282401 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/8388548 PubMed] | ||
[[Category:Medulloblastoma regimens]] | [[Category:Medulloblastoma regimens]] | ||
[[Category:Disease-specific pages]] | [[Category:Disease-specific pages]] | ||
[[Category:Pediatric cancers]] | [[Category:Pediatric cancers]] | ||
Revision as of 18:28, 24 October 2018
| Section editor | |
|---|---|
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Wayne H. Liang, MD, MS Birmingham, AL Twitter: WayneLiangMD |
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Adjuvant therapy
Carboplatin, Cyclophosphamide, Etoposide, Methotrexate, Vincristine
| back to top |
Regimen
| Study | Evidence |
|---|---|
| Rutkowski et al. 2005 | Non-randomized |
Preceding treatment
- Surgery
Chemotherapy
- Carboplatin (Paraplatin)
- Cyclophosphamide (Cytoxan)
- Etoposide (Vepesid)
- Methotrexate (MTX)
- Vincristine (Oncovin)
References
- Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, Soerensen N, Graf N, Emser A, Pietsch T, Wolff JE, Kortmann RD, Kuehl J. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med. 2005 Mar 10;352(10):978-86. link to original article PubMed
Cyclophosphamide & Vincristine/Cisplatin & Etoposide
| back to top |
Regimen
| Study | Evidence |
|---|---|
| Duffner et al. 1993 | Non-randomized |
Total duration of treatment is 12 to 24 months.
Preceding treatment
- Surgical resection or biopsy
Chemotherapy, part 1
28-day cycle for 2 cycles, alternating with part 2
Chemotherapy, part 2
28-day cycle for 1 cycle, alternating with part 1
References
- Duffner PK, Horowitz ME, Krischer JP, Friedman HS, Burger PC, Cohen ME, Sanford RA, Mulhern RK, James HE, Freeman CR, Seidel FG, Kun LE. Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med. 1993 Jun 17;328(24):1725-31. link to original article PubMed