Difference between revisions of "Classical Hodgkin lymphoma - historical"
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# Diggs CH, Wiernik PH, Sutherland JC. Treatment of advanced untreated Hodgkin's disease with SCAB--an alternative to MOPP. Cancer. 1981 Jan 15;47(2):224-8. [http://onlinelibrary.wiley.com/doi/10.1002/1097-0142(19810115)47:2%3C224::AID-CNCR2820470203%3E3.0.CO;2-6/abstract link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/6161689 PubMed] | # Diggs CH, Wiernik PH, Sutherland JC. Treatment of advanced untreated Hodgkin's disease with SCAB--an alternative to MOPP. Cancer. 1981 Jan 15;47(2):224-8. [http://onlinelibrary.wiley.com/doi/10.1002/1097-0142(19810115)47:2%3C224::AID-CNCR2820470203%3E3.0.CO;2-6/abstract link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/6161689 PubMed] | ||
## '''Update:''' Wiernik PH, Schiffer CA. Long-term follow-up of advanced Hodgkin's disease patients treated with a combination of streptozotocin, lomustine (CCNU), doxorubicin and bleomycin (SCAB). J Cancer Res Clin Oncol. 1988;114(1):105-7. [https://www.ncbi.nlm.nih.gov/pubmed/2450876 PubMed] | ## '''Update:''' Wiernik PH, Schiffer CA. Long-term follow-up of advanced Hodgkin's disease patients treated with a combination of streptozotocin, lomustine (CCNU), doxorubicin and bleomycin (SCAB). J Cancer Res Clin Oncol. 1988;114(1):105-7. [https://www.ncbi.nlm.nih.gov/pubmed/2450876 PubMed] | ||
+ | |||
+ | ==VEPEMB {{#subobject:2c05e6|Regimen=1}}== | ||
+ | {| class="wikitable" style="float:right; margin-left: 5px;" | ||
+ | |- | ||
+ | |[[#top|back to top]] | ||
+ | |} | ||
+ | VEPEMB: '''<u>V</u>'''inblastine, '''<u>E</u>'''ndoxan (Cyclophosphamide), '''<u>P</u>'''rocarbazine, '''<u>E</u>'''toposide, '''<u>M</u>'''itoxantrone, '''<u>B</u>'''leomycin | ||
+ | ===Regimen {{#subobject:9a2b97|Variant=1}}=== | ||
+ | {| class="wikitable" style="width: 100%; text-align:center;" | ||
+ | !Study | ||
+ | ![[Levels_of_Evidence#Evidence|Evidence]] | ||
+ | !Comparator | ||
+ | ![[Levels_of_Evidence#Efficacy|Efficacy]] | ||
+ | |- | ||
+ | |[http://annonc.oxfordjournals.org/content/15/1/123.long Levis et al. 2004] | ||
+ | |style="background-color:#91cf61"|Phase II | ||
+ | |style="background-color:#d3d3d3"| | ||
+ | |style="background-color:#d3d3d3"| | ||
+ | |- | ||
+ | |[http://onlinelibrary.wiley.com/doi/10.1111/bjh.13904/full Zallio et al. 2016] | ||
+ | |style="background-color:#1a9851"|Phase III | ||
+ | |ABVD | ||
+ | |style="background-color:#fee08b"|Might have inferior PFS | ||
+ | |- | ||
+ | |} | ||
+ | ''This regimen is intended for elderly patients. Unlikely to be completed given the phase III results.'' | ||
+ | ====Chemotherapy==== | ||
+ | *[[Vinblastine (Velban)]] | ||
+ | *[[Cyclophosphamide (Cytoxan)]] | ||
+ | *[[Procarbazine (Matulane)]] | ||
+ | *[[Etoposide (Vepesid)]] | ||
+ | *[[Mitoxantrone (Novantrone)]] | ||
+ | *[[Bleomycin (Blenoxane)]] | ||
+ | ===References=== | ||
+ | # Levis A, Anselmo AP, Ambrosetti A, Adamo F, Bertini M, Cavalieri E, Gavarotti P, Genua A, Liberati M, Pavone V, Pietrasanta D, Ricetti MM, Scalabrini DR, Salvi F, Vitolo U, Angelucci E, Boccadoro M, Gallo E, Mandelli F; Intergruppo Italiano Linfomi (IIL). VEPEMB in elderly Hodgkin's lymphoma patients. Results from an Intergruppo Italiano Linfomi (IIL) study. Ann Oncol. 2004 Jan;15(1):123-8. [http://annonc.oxfordjournals.org/content/15/1/123.long link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/14679131 PubMed] | ||
+ | ## '''Update:''' Proctor SJ, Wilkinson J, Jones G, Watson GC, Lucraft HH, Mainou-Fowler T, Culligan D, Galloway MJ, Wood KM, McNally RJ, James PW, Goodlad JR. Evaluation of treatment outcome in 175 patients with Hodgkin lymphoma aged 60 years or over: the SHIELD study. Blood. 2012 Jun 21;119(25):6005-15. Epub 2012 May 10. [http://www.bloodjournal.org/content/119/25/6005.long link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/22577177 PubMed] | ||
+ | # Zallio F, Tamiazzo S, Monagheddu C, Merli F, Ilariucci F, Stelitano C, Liberati AM, Mannina D, Vitolo U, Angelucci E, Rota Scalabrini D, Vallisa D, Bellei M, Bari A, Ciccone G, Salvi F, Levis A. Reduced intensity VEPEMB regimen compared with standard ABVD in elderly Hodgkin lymphoma patients: results from a randomized trial on behalf of the Fondazione Italiana Linfomi (FIL). Br J Haematol. 2016 Mar;172(6):879-88. Epub 2016 Jan 13. [http://onlinelibrary.wiley.com/doi/10.1111/bjh.13904/full link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/26763986 PubMed] | ||
=Relapsed or refractory, salvage therapy= | =Relapsed or refractory, salvage therapy= |
Revision as of 14:22, 14 January 2018
Hello! |
Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer. If this is your first time visiting, we suggest you read the tutorial.
The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. Is there a regimen missing from this list? See the main Hodgkin lymphoma page for current regimens.
30 regimens on this page
37 variants on this page
|
Untreated
COPP
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COPP: CCNU (Lomustine), Oncovin (Vincristine), Procarbazine, Prednisone
Regimen
Study | Evidence | Comparator | Efficacy |
---|---|---|---|
Cooper et al. 1980 | Phase III | CVPP | Seems not superior |
MOPP | Seems not superior | ||
MVPP | Seems not superior |
Chemotherapy
References
- Cooper MR, Pajak TF, Nissen NI, Stutzman L, Brunner K, Cuttner J, Falkson G, Grunwald H, Bank A, Leone L, Seligman BR, Silver RT, Weiss RB, Haurani F, Blom J, Spurr CL, Glidewell OJ, Gottlieb AJ, Holland JF. A new effective four-drug combination of CCNU (1-[2-chloroethyl]-3-cyclohexyl-1-nitrosourea) (NSC-79038), vinblastine, prednisone, and procarbazine for the treatment of advanced Hodgkin's disease. Cancer. 1980 Aug 15;46(4):654-62. link to original article PubMed
CVPP
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CVPP: CCNU (Lomustine), Vinblastine, Procarbazine, Prednisone
Regimen
Study | Evidence | Comparator | Efficacy |
---|---|---|---|
Cooper et al. 1980 | Phase III | COPP | Seems not superior |
MOPP | Seems to have superior CR rate | ||
MVPP | Seems not superior |
Chemotherapy
References
- Cooper MR, Pajak TF, Nissen NI, Stutzman L, Brunner K, Cuttner J, Falkson G, Grunwald H, Bank A, Leone L, Seligman BR, Silver RT, Weiss RB, Haurani F, Blom J, Spurr CL, Glidewell OJ, Gottlieb AJ, Holland JF. A new effective four-drug combination of CCNU (1-[2-chloroethyl]-3-cyclohexyl-1-nitrosourea) (NSC-79038), vinblastine, prednisone, and procarbazine for the treatment of advanced Hodgkin's disease. Cancer. 1980 Aug 15;46(4):654-62. link to original article PubMed
MVPP
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MVPP: Mechlorethamine, Vinblastine, Procarbazine, Prednisone
Regimen
Study | Evidence | Comparator | Efficacy |
---|---|---|---|
Cooper et al. 1980 | Phase III | COPP | Seems not superior |
CVPP | Seems not superior | ||
MOPP | Seems not superior |
Chemotherapy
References
- Cooper MR, Pajak TF, Nissen NI, Stutzman L, Brunner K, Cuttner J, Falkson G, Grunwald H, Bank A, Leone L, Seligman BR, Silver RT, Weiss RB, Haurani F, Blom J, Spurr CL, Glidewell OJ, Gottlieb AJ, Holland JF. A new effective four-drug combination of CCNU (1-[2-chloroethyl]-3-cyclohexyl-1-nitrosourea) (NSC-79038), vinblastine, prednisone, and procarbazine for the treatment of advanced Hodgkin's disease. Cancer. 1980 Aug 15;46(4):654-62. link to original article PubMed
NOVP
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NOVP: Novantrone (Mitoxantrone), Oncovin (Vincristine), Vinblastine, Prednisone
Regimen
Study | Evidence |
---|---|
Hagemeister et al. 1990 | Phase II |
Chemotherapy
References
- Hagemeister FB, Cabanillas F, Velásquez WS, Meistrich ML, Liang JC, McLaughlin P, Redman JR, Romaguera JE, Rodríguez MA, Swan F Jr, et al. NOVP: a novel chemotherapeutic regimen with minimal toxicity for treatment of Hodgkin's disease. Semin Oncol. 1990 Dec;17(6 Suppl 10):34-8.PubMed
SCAB
back to top |
SCAB: Streptozocin, CCNU (Lomustine), Adriamycin (Doxorubicin), Bleomycin
Regimen
Study | Evidence |
---|---|
Diggs et al. 1981 | Non-randomized |
Chemotherapy
References
- Diggs CH, Wiernik PH, Sutherland JC. Treatment of advanced untreated Hodgkin's disease with SCAB--an alternative to MOPP. Cancer. 1981 Jan 15;47(2):224-8. link to original article PubMed
- Update: Wiernik PH, Schiffer CA. Long-term follow-up of advanced Hodgkin's disease patients treated with a combination of streptozotocin, lomustine (CCNU), doxorubicin and bleomycin (SCAB). J Cancer Res Clin Oncol. 1988;114(1):105-7. PubMed
VEPEMB
back to top |
VEPEMB: Vinblastine, Endoxan (Cyclophosphamide), Procarbazine, Etoposide, Mitoxantrone, Bleomycin
Regimen
Study | Evidence | Comparator | Efficacy |
---|---|---|---|
Levis et al. 2004 | Phase II | ||
Zallio et al. 2016 | Phase III | ABVD | Might have inferior PFS |
This regimen is intended for elderly patients. Unlikely to be completed given the phase III results.
Chemotherapy
- Vinblastine (Velban)
- Cyclophosphamide (Cytoxan)
- Procarbazine (Matulane)
- Etoposide (Vepesid)
- Mitoxantrone (Novantrone)
- Bleomycin (Blenoxane)
References
- Levis A, Anselmo AP, Ambrosetti A, Adamo F, Bertini M, Cavalieri E, Gavarotti P, Genua A, Liberati M, Pavone V, Pietrasanta D, Ricetti MM, Scalabrini DR, Salvi F, Vitolo U, Angelucci E, Boccadoro M, Gallo E, Mandelli F; Intergruppo Italiano Linfomi (IIL). VEPEMB in elderly Hodgkin's lymphoma patients. Results from an Intergruppo Italiano Linfomi (IIL) study. Ann Oncol. 2004 Jan;15(1):123-8. link to original article PubMed
- Update: Proctor SJ, Wilkinson J, Jones G, Watson GC, Lucraft HH, Mainou-Fowler T, Culligan D, Galloway MJ, Wood KM, McNally RJ, James PW, Goodlad JR. Evaluation of treatment outcome in 175 patients with Hodgkin lymphoma aged 60 years or over: the SHIELD study. Blood. 2012 Jun 21;119(25):6005-15. Epub 2012 May 10. link to original article PubMed
- Zallio F, Tamiazzo S, Monagheddu C, Merli F, Ilariucci F, Stelitano C, Liberati AM, Mannina D, Vitolo U, Angelucci E, Rota Scalabrini D, Vallisa D, Bellei M, Bari A, Ciccone G, Salvi F, Levis A. Reduced intensity VEPEMB regimen compared with standard ABVD in elderly Hodgkin lymphoma patients: results from a randomized trial on behalf of the Fondazione Italiana Linfomi (FIL). Br J Haematol. 2016 Mar;172(6):879-88. Epub 2016 Jan 13. link to original article PubMed
Relapsed or refractory, salvage therapy
ABDIC
back to top |
ABDIC: Adriamycin (Doxorubicin), Bleomycin, DIC (Dacarbazine), CCNU (Lomustine), Prednisone
Regimen
Study | Evidence |
---|---|
Rodgers et al. 1980 | Phase II |
Chemotherapy
- Doxorubicin (Adriamycin)
- Bleomycin (Blenoxane)
- Dacarbazine (DTIC)
- Lomustine (Ceenu)
- Prednisone (Sterapred)
References
- Rodgers RW, Gamble JF, Loh KK, Shullenberger CC. Adriamycin, bleomycin, DIC, CCNU, and prednisone (ABDIC) chemotherapy in MOPP-resistant Hodgkin's disease. Cancer. 1980 Dec 1;46(11):2349-55. link to original article PubMed
- Update: Tannir N, Hagemeister F, Velasquez W, Cabanillas F. Long-term follow-up with ABDIC salvage chemotherapy of MOPP-resistant Hodgkin's disease. J Clin Oncol. 1983 Jul;1(7):432-9. link to original article PubMed
ABVD
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ABVD: Adriamycin (Doxorubicin), Bleomycin, Vinblastine, Dacarbazine
Regimen
Study | Evidence |
---|---|
Krikorian et al. 1978 | Phase II |
Santoro et al. 1979 | Phase II |
Harker et al. 1984 | Non-randomized |
This is for historical interest only; ABVD is no longer used in the salvage setting.
Chemotherapy
References
- Krikorian JG, Portlock CS, Rosenberg SA. Treatment of advanced Hodgkin's disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide (ABVD) after failure of MOPP therapy. Cancer. 1978 Jun;41(6):2107-11. link to original article PubMed
- Santoro A, Bonadonna G. Prolonged disease-free survival in MOPP-resistant Hodgkin's disease after treatment with adriamycin, bleomycin, vinblastine and dacarbazine (ABVD). Cancer Chemother Pharmacol. 1979;2(2):101-5. PubMed
- Santoro A, Bonfante V, Bonadonna G. Salvage chemotherapy with ABVD in MOPP-resistant Hodgkin's disease. Ann Intern Med. 1982 Feb;96(2):139-43. link to original article PubMed
- Harker WG, Kushlan P, Rosenberg SA. Combination chemotherapy for advanced Hodgkin's disease after failure of MOPP: ABVD and B-CAVe. Ann Intern Med. 1984 Oct;101(4):440-6. link to original article PubMed
B-CAVe
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B-CAVe: Bleomycin, CCNU (Lomustine), Adriamycin (Doxorubicin), Vinblastine
Regimen
Study | Evidence |
---|---|
Porzig et al. 1978 | Non-randomized |
Harker et al. 1984 | Non-randomized |
Chemotherapy
References
- Porzig KJ, Portlock CS, Robertson A, Rosenberg SA. Treatment of advanced Hodgkin's disease with B-CAVE following MOPP failure. Cancer. 1978 May;41(5):1670-5. link to original article PubMed
- Harker WG, Kushlan P, Rosenberg SA. Combination chemotherapy for advanced Hodgkin's disease after failure of MOPP: ABVD and B-CAVe. Ann Intern Med. 1984 Oct;101(4):440-6. link to original article PubMed
BVCPP
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BVCPP: BCNU (Carmustine), Vinblastine, Cyclophosphamide, Procarbazine, Prednisone
Regimen
Study | Evidence |
---|---|
Durant et al. 1978 | Non-randomized |
Chemotherapy
- Carmustine (BiCNU)
- Vinblastine (Velban)
- Cyclophosphamide (Cytoxan)
- Procarbazine (Matulane)
- Prednisone (Sterapred)
Patients who achieved CR were randomized to no additional therapy, 6 monthly cycles of MOPP or 6 additional monthly cycles of BVCPP.
References
- Durant JR, Gams RA, Velez-Garcia E, Bartolucci A, Wirtschafter D, Dorfman R. BCNU, velban, cyclophosphamide, procarbazine, and prednisone (BVCPP) in advanced Hodgkin's disease. Cancer. 1978 Nov;42(5):2101-10. link to original article PubMed
CEP
back to top |
CEP: CCNU (Lomustine), Etoposide, Prednimustine
Regimen
Study | Evidence |
---|---|
Santoro et al. 1986 | Non-randomized |
Chemotherapy
References
- Santoro A, Viviani S, Valagussa P, Bonfante V, Bonadonna G. CCNU, etoposide, and prednimustine (CEP) in refractory Hodgkin's disease. Semin Oncol. 1986 Mar;13(1 Suppl 1):23-6. PubMed
SCAB
back to top |
SCAB: Streptozocin, CCNU (Lomustine), Adriamycin (Doxorubicin), Bleomycin
Regimen
Study | Evidence |
---|---|
Levi et al. 1977 | Non-randomized, <20 pts |
Chemotherapy
References
- Levi JA, Wiernik PH, Diggs CH. Combination chemotherapy of advanced previously treated Hodgkin's disease with streptozotocin, CCNU, adriamycin and bleomycin. Med Pediatr Oncol. 1977;3(1):33-40. PubMed