Difference between revisions of "Cyclophosphamide (Cytoxan)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
| + | <div style="column-count:3;-moz-column-count:3;-webkit-column-count:3"> | ||
*[[Acute lymphocytic leukemia]] | *[[Acute lymphocytic leukemia]] | ||
| − | |||
*[[Anaplastic large cell lymphoma]] | *[[Anaplastic large cell lymphoma]] | ||
*[[Bladder cancer]] | *[[Bladder cancer]] | ||
*[[Bone cancer]] | *[[Bone cancer]] | ||
*[[Breast cancer]] | *[[Breast cancer]] | ||
| + | *[[Burkitt lymphoma]] | ||
*[[Central nervous system (CNS) cancer]] | *[[Central nervous system (CNS) cancer]] | ||
*[[Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)]] | *[[Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)]] | ||
*[[CNS lymphoma]] | *[[CNS lymphoma]] | ||
| + | *[[Coagulopathies]] | ||
| + | *[[Diffuse large B-cell lymphoma]] | ||
*[[Follicular lymphoma]] | *[[Follicular lymphoma]] | ||
*[[HIV-associated lymphoma]] | *[[HIV-associated lymphoma]] | ||
*[[Hodgkin lymphoma]] | *[[Hodgkin lymphoma]] | ||
*[[Hodgkin lymphoma, nodular lymphocyte-predominant]] | *[[Hodgkin lymphoma, nodular lymphocyte-predominant]] | ||
| + | *[[Large granular lymphocytic leukemia]] | ||
*[[Light-chain (AL) amyloidosis]] | *[[Light-chain (AL) amyloidosis]] | ||
*[[Mantle cell lymphoma]] | *[[Mantle cell lymphoma]] | ||
| Line 27: | Line 31: | ||
*[[Neuroendocrine tumors]] | *[[Neuroendocrine tumors]] | ||
*[[Peripheral T-cell lymphoma]] | *[[Peripheral T-cell lymphoma]] | ||
| + | *[[Primary mediastinal B-cell lymphoma]] | ||
*[[Prostate cancer]] | *[[Prostate cancer]] | ||
*[[Small cell lung cancer]] | *[[Small cell lung cancer]] | ||
| − | |||
*[[Thymoma]] | *[[Thymoma]] | ||
| + | *[[Transformed lymphoma]] | ||
*[[Transplant conditioning regimens]] | *[[Transplant conditioning regimens]] | ||
*[[Waldenström macroglobulinemia]] | *[[Waldenström macroglobulinemia]] | ||
| + | </div> | ||
==Patient drug information== | ==Patient drug information== | ||
Revision as of 12:42, 17 May 2015
General information
Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.[1][2]
Route: IV, PO
Extravasation: irritant, n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute lymphocytic leukemia
- Anaplastic large cell lymphoma
- Bladder cancer
- Bone cancer
- Breast cancer
- Burkitt lymphoma
- Central nervous system (CNS) cancer
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)
- CNS lymphoma
- Coagulopathies
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- HIV-associated lymphoma
- Hodgkin lymphoma
- Hodgkin lymphoma, nodular lymphocyte-predominant
- Large granular lymphocytic leukemia
- Light-chain (AL) amyloidosis
- Mantle cell lymphoma
- Marginal zone lymphoma
- Mediastinal gray-zone lymphoma
- Multiple myeloma
- Neuroendocrine tumors
- Peripheral T-cell lymphoma
- Primary mediastinal B-cell lymphoma
- Prostate cancer
- Small cell lung cancer
- Thymoma
- Transformed lymphoma
- Transplant conditioning regimens
- Waldenström macroglobulinemia
Patient drug information
- Cyclophosphamide (Cytoxan) patient drug information (Chemocare)[3]
- Cyclophosphamide (Cytoxan) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 11/16/1959: initial FDA approval
Also known as
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| Alkyloxan | Biodoxan | Carloxan | Ciclofosfamida | Ciclofosfamida Filaxis | Ciclofosfamida Martian | Ciclokebir | Cyclam |
| Cycloblastin | Cycloblastine | Cyclo Cell | Cycloferon | Cyclomide | Cyclophar | Cyclophospham | Cyclophosphamid |
| cyclophosphamide monohydrate | Cyclophosphamid Farmos | Cyclophosphan | Cyclophosphan Lens | Cyclostin | Cycloxan | Cycram | Cydoxan |
| Cyklofosfamid | Cytophosphan | Cytoxan | Cytoxan Lyophilized | Endoxan | Endoxan-N | Endoxana | Endoxan Asta |
| Formitex | Genoxal | Genuxal | Hidrofosmin | Ledoxan | Ledoxina | Lyophilized Cytoxan | Neosar |
| Oncomide | Oncophos | Procytox | Revimmune | Sendoxan | Syklofosfamid | Trav Cyclophosphamide | Tymtran |
| Zycram | |||||||
References
Categories:
- Drug index
- Chemotherapy
- Intravenous chemotherapy
- Irritant chemotherapy
- Oral chemotherapy
- Alkylating agents
- Nitrogen mustards
- Acute lymphocytic leukemia medications
- Aggressive Non-Hodgkin lymphoma medications
- Anaplastic large cell lymphoma medications
- Bladder cancer medications
- Bone cancer medications
- Breast cancer medications
- Central nervous system (CNS) cancer medications
- Central nervous system (CNS) lymphoma medications
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications
- Follicular lymphoma medications
- HIV-associated lymphoma medications
- Hodgkin lymphoma medications
- Hodgkin lymphoma, nodular lymphocyte-predominant medications
- Light-chain (AL) amyloidosis medications
- Mantle cell lymphoma medications
- Marginal zone lymphoma medications
- Mediastinal gray-zone lymphoma medications
- Multiple myeloma medications
- Neuroendocrine tumor medications
- Peripheral T-cell lymphoma medications
- Prostate cancer medications
- Small cell lung cancer medications
- T-cell lymphoma medications
- Thymoma medications
- Transplant medications
- Waldenström macroglobulinemia medications
- Drugs FDA approved in 1959