Difference between revisions of "Etoposide (Vepesid)"

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==Diseases for which it is used==
 
==Diseases for which it is used==
 +
<div style="column-count:3;-moz-column-count:3;-webkit-column-count:3">
 
*[[Acute myeloid leukemia]]
 
*[[Acute myeloid leukemia]]
 
*[[Acute promyelocytic leukemia]]
 
*[[Acute promyelocytic leukemia]]
 
*[[Acute lymphocytic leukemia]]
 
*[[Acute lymphocytic leukemia]]
−
*[[Aggressive Non-Hodgkin lymphoma]]
+
*[[Anaplastic large cell lymphoma]]
 
*[[Bone cancer]]  
 
*[[Bone cancer]]  
 +
*[[Burkitt lymphoma]]
 
*[[Central nervous system (CNS) cancer]]
 
*[[Central nervous system (CNS) cancer]]
 +
*[[Diffuse large B-cell lymphoma]]
 
*[[Esophageal cancer]]
 
*[[Esophageal cancer]]
 +
*[[Extranodal NK/T-cell lymphoma, nasal type]]
 
*[[Follicular lymphoma]]
 
*[[Follicular lymphoma]]
 +
*[[Hemophagocytic lymphohistiocytosis]]
 
*[[Hepatobiliary cancer]]
 
*[[Hepatobiliary cancer]]
 
*[[HIV-associated lymphoma]]
 
*[[HIV-associated lymphoma]]
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*[[Multiple myeloma]]
 
*[[Multiple myeloma]]
 
*[[Neuroendocrine tumors]]
 
*[[Neuroendocrine tumors]]
 +
*[[NK/T-cell lymphoma]]
 
*[[Non-small cell lung cancer]]
 
*[[Non-small cell lung cancer]]
 
*[[Ovarian cancer]]
 
*[[Ovarian cancer]]
 +
*[[Peripheral T-cell lymphoma]]
 +
*[[Primary mediastinal B-cell lymphoma]]
 
*[[Sarcoma]]  
 
*[[Sarcoma]]  
 
*[[Small cell lung cancer]]
 
*[[Small cell lung cancer]]
−
*[[T-cell lymphoma]]
 
 
*[[Testicular cancer]]
 
*[[Testicular cancer]]
 
*[[Thymoma]]
 
*[[Thymoma]]
 +
*[[Transformed lymphoma]]
 
*[[Unknown primary]]
 
*[[Unknown primary]]
 +
</div>
  
 
==Patient drug information==
 
==Patient drug information==
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[[Category:Acute promyelocytic leukemia medications]]
 
[[Category:Acute promyelocytic leukemia medications]]
 
[[Category:Aggressive Non-Hodgkin lymphoma medications]]
 
[[Category:Aggressive Non-Hodgkin lymphoma medications]]
 +
[[Category:Anaplastic large cell lymphoma medications]]
 
[[Category:Bone cancer medications]]  
 
[[Category:Bone cancer medications]]  
 +
[[Category:Burkitt lymphoma medications]]
 
[[Category:Cancer of unknown primary medications]]  
 
[[Category:Cancer of unknown primary medications]]  
 
[[Category:Central nervous system (CNS) cancer medications]]
 
[[Category:Central nervous system (CNS) cancer medications]]
 +
[[Category:Diffuse large B-cell lymphoma medications]]
 
[[Category:Esophageal cancer medications]]
 
[[Category:Esophageal cancer medications]]
 +
[[Category:Extranodal NK/T-cell lymphoma, nasal type medications]]
 
[[Category:Follicular lymphoma medications]]
 
[[Category:Follicular lymphoma medications]]
 +
[[Category:Hemophagocytic lymphohistiocytosis medications]]
 
[[Category:Hepatobiliary cancer medications]]
 
[[Category:Hepatobiliary cancer medications]]
 
[[Category:HIV-associated lymphoma medications]]
 
[[Category:HIV-associated lymphoma medications]]
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[[Category:Multiple myeloma medications]]
 
[[Category:Multiple myeloma medications]]
 
[[Category:Neuroendocrine tumor medications]]
 
[[Category:Neuroendocrine tumor medications]]
 +
[[Category:NK/T-cell lymphoma medications]]
 
[[Category:Non-small cell lung cancer medications]]
 
[[Category:Non-small cell lung cancer medications]]
 
[[Category:Ovarian cancer medications]]
 
[[Category:Ovarian cancer medications]]
 +
[[Category:Primary mediastinal B-cell lymphoma medications]]
 
[[Category:Sarcoma medications]]  
 
[[Category:Sarcoma medications]]  
 
[[Category:Small cell lung cancer medications]]
 
[[Category:Small cell lung cancer medications]]

Revision as of 00:25, 13 May 2015

General information

Class/mechanism: Topoisomerase II inhibitor. Causes DNA strand breaks by interacting with DNA-topoisomerase II or by forming free radicals. Causes arrest at the G2 portion of the cell cycle, with dose dependent effects: at high concentrations, cells entering mitosis undergo lysis; at low concentrations, cells are inhibited from entering prophase.[1][2]
Route: IV, PO
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

Synonyms
Abic Etoposide Aside Beposid Bioposide BO RUI Bristol VP-16 Celltop Citodox
Epocin Eposid Eposide Eposido Eposin Epsidox ETO Etocris
Etomedac Etonolver Etopofos Etopophos Etopos Etoposid Etoposide Abic Etoposid Ebewe
Etoposide Bigmar Etoposide BVI Etoposide Dakota Etoposide DBL Etoposide DUP Etoposide Ebewe Etoposide Eurocept Etoposide Merck
Etoposide Pfizer etoposide phosphate Etoposide Teva Etoposid Mayne Etoposido Etoposido Delta Farma Etoposido Ferrer Etoposido GI Kendr
Etoposido Servycal Etoposido Varifarm Etoposid Proreo Etoposid Teva Etopoxan Etopul Etosid Etosin
Eunades CS Euvaxon Exitop Fytop Fytosid HAI WEI LIN Labimion Lastet
Lastet S Neoplaxol Nexvep Onkoposid Optasid P&U Etoposide Percas Posid
Posidon Posyd Riboposid Sintopozid Toposar Toposide Toposin Topresid
Tosuben Vepefos Vepeside Vepesid K Vepesid S Vepesid VP-16 Vepsid Vepside
VP-16 VP-TEC VP 16213

References

  1. ↑ 1.0 1.1 Etoposide (Vepesid) package insert
  2. ↑ Etoposide (Vepesid) package insert (locally hosted backup)
  3. ↑ Etoposide (Vepesid) patient drug information (Chemocare)
  4. ↑ Etoposide (Vepesid) patient drug information (UpToDate)
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