Difference between revisions of "Dexamethasone (Decadron)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Corticosteroid & glucocorticoid which has numerous physiologic effects, including immune system modulation, [[Antiemesis|antiemetic properties]], and anti-inflammatory effects.<ref name="insert">[http://bidocs.boehringer-ingelheim.com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/Prescribing+Information/PIs/Roxane/Dexamethasone/Dexamethasone+Tablets+Solution+and+Intensol.pdf Dexamethasone (Decadron) package insert]</ref><ref>[[ | + | Class/mechanism: Corticosteroid & glucocorticoid which has numerous physiologic effects, including immune system modulation, [[Antiemesis|antiemetic properties]], and anti-inflammatory effects.<ref name="insert">[http://bidocs.boehringer-ingelheim.com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/Prescribing+Information/PIs/Roxane/Dexamethasone/Dexamethasone+Tablets+Solution+and+Intensol.pdf Dexamethasone (Decadron) package insert]</ref><ref>[[:File:Dexamethasone.pdf | Dexamethasone (Decadron) package insert (locally hosted backup)]]</ref> |
<br>Route: PO, IV, IM | <br>Route: PO, IV, IM | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
| Line 7: | Line 7: | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is established ''(work in progress)''== | ||
| + | *[[Peripheral T-cell lymphoma]] | ||
==Diseases for which it is used== | ==Diseases for which it is used== | ||
<div style="column-count:3;-moz-column-count:3;-webkit-column-count:3"> | <div style="column-count:3;-moz-column-count:3;-webkit-column-count:3"> | ||
*[[Anaplastic large cell lymphoma]] | *[[Anaplastic large cell lymphoma]] | ||
| − | |||
*[[B-cell acute lymphoblastic leukemia]] | *[[B-cell acute lymphoblastic leukemia]] | ||
*[[Burkitt lymphoma]] | *[[Burkitt lymphoma]] | ||
| Line 20: | Line 22: | ||
*[[Hemophagocytic lymphohistiocytosis]] | *[[Hemophagocytic lymphohistiocytosis]] | ||
*[[HIV-associated lymphoma]] | *[[HIV-associated lymphoma]] | ||
| − | *[[Hodgkin lymphoma]] | + | *[[Classical Hodgkin lymphoma]] |
| + | *[[Immune thrombocytopenia (ITP)]] | ||
*[[Light-chain (AL) amyloidosis]] | *[[Light-chain (AL) amyloidosis]] | ||
*[[Mantle cell lymphoma]] | *[[Mantle cell lymphoma]] | ||
| − | |||
*[[Multiple myeloma]] | *[[Multiple myeloma]] | ||
| − | *[[NK | + | *[[NK- and T-cell lymphoma]] |
| − | |||
*[[Plasma cell leukemia]] | *[[Plasma cell leukemia]] | ||
*[[POEMS syndrome]] | *[[POEMS syndrome]] | ||
*[[Primary mediastinal B-cell lymphoma]] | *[[Primary mediastinal B-cell lymphoma]] | ||
| + | *[[Smoldering multiple myeloma]] | ||
*[[T-cell acute lymphoblastic leukemia]] | *[[T-cell acute lymphoblastic leukemia]] | ||
*[[Transformed lymphoma]] | *[[Transformed lymphoma]] | ||
*[[Waldenström macroglobulinemia]] | *[[Waldenström macroglobulinemia]] | ||
</div> | </div> | ||
| + | |||
| + | ==Diseases for which it was used== | ||
| + | *[[Acute myeloid leukemia - historical|Acute myeloid leukemia]] | ||
| + | *[[Prostate cancer - historical|Prostate cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/ | + | *[http://bidocs.boehringer-ingelheim.com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/Prescribing+Information/PIs/Roxane/Dexamethasone/Dexamethasone+Tablets+Solution+and+Intensol.pdf Dexamethasone (Decadron) package insert]<ref name="insert"></ref> |
| + | *[https://chemocare.com/druginfo/dexamethasone.aspx Dexamethasone (Decadron) patient drug information (Chemocare)]<ref>[https://chemocare.com/druginfo/dexamethasone.aspx Dexamethasone (Decadron) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/dexamethasone-patient-drug-information Dexamethasone (Decadron) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dexamethasone-patient-drug-information Dexamethasone (Decadron) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/dexamethasone-patient-drug-information Dexamethasone (Decadron) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dexamethasone-patient-drug-information Dexamethasone (Decadron) patient drug information (UpToDate)]</ref> | ||
| + | |||
| + | ==History of changes in EMA indication== | ||
| + | *1952-01-01: EURD | ||
| + | ==History of changes in PMDA indication== | ||
| + | *2010-06-18: New additional indication and a new dosage for the treatment of [[multiple myeloma]]. | ||
| + | *2021-08-25: New indication and a new dosage for the treatment of [[Light-chain (AL) amyloidosis|systemic AL amyloidosis]]. | ||
==Also known as== | ==Also known as== | ||
| Line 501: | Line 514: | ||
|Zenos | |Zenos | ||
|Zydexa | |Zydexa | ||
| + | |Baycadron | ||
| + | |ZoDex | ||
| + | |- | ||
| + | |Neofordex | ||
| + | |LenaDex | ||
|} | |} | ||
| Line 507: | Line 525: | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
| + | [[Category:Intramuscular medications]] | ||
| + | [[Category:Intravenous medications]] | ||
| + | [[Category:Oral medications]] | ||
[[Category:Steroids]] | [[Category:Steroids]] | ||
| Line 514: | Line 535: | ||
[[Category:CNS lymphoma medications]] | [[Category:CNS lymphoma medications]] | ||
[[Category:Diffuse large B-cell lymphoma medications]] | [[Category:Diffuse large B-cell lymphoma medications]] | ||
| − | [[Category:Extranodal NK | + | [[Category:Extranodal NK- and T-cell lymphoma, nasal type medications]] |
[[Category:Follicular lymphoma medications]] | [[Category:Follicular lymphoma medications]] | ||
[[Category:Hemophagocytic lymphohistiocytosis medications]] | [[Category:Hemophagocytic lymphohistiocytosis medications]] | ||
[[Category:HIV-associated lymphoma medications]] | [[Category:HIV-associated lymphoma medications]] | ||
| − | [[Category:Hodgkin lymphoma medications]] | + | [[Category:Classical Hodgkin lymphoma medications]] |
[[Category:Immune thrombocytopenia medications]] | [[Category:Immune thrombocytopenia medications]] | ||
[[Category:Light-chain (AL) amyloidosis medications]] | [[Category:Light-chain (AL) amyloidosis medications]] | ||
[[Category:Mantle cell lymphoma medications]] | [[Category:Mantle cell lymphoma medications]] | ||
[[Category:Multiple myeloma medications]] | [[Category:Multiple myeloma medications]] | ||
| − | [[Category:NK | + | [[Category:NK- and T-cell lymphoma medications]] |
[[Category:Peripheral T-cell lymphoma medications]] | [[Category:Peripheral T-cell lymphoma medications]] | ||
[[Category:Plasma cell leukemia medications]] | [[Category:Plasma cell leukemia medications]] | ||
[[Category:POEMS syndrome medications]] | [[Category:POEMS syndrome medications]] | ||
[[Category:Primary mediastinal B-cell lymphoma medications]] | [[Category:Primary mediastinal B-cell lymphoma medications]] | ||
| + | [[Category:Smoldering multiple myeloma medications]] | ||
[[Category:T-cell acute lymphoblastic leukemia medications]] | [[Category:T-cell acute lymphoblastic leukemia medications]] | ||
[[Category:Transformed lymphoma medications]] | [[Category:Transformed lymphoma medications]] | ||
[[Category:Waldenström macroglobulinemia medications]] | [[Category:Waldenström macroglobulinemia medications]] | ||
| + | |||
| + | [[Category:Acute myeloid leukemia medications (historic)]] | ||
| + | [[Category:Prostate cancer medications (historic)]] | ||
[[Category:FDA approved in 1958]] | [[Category:FDA approved in 1958]] | ||
| + | [[Category:EMA approved in 1952]] | ||
[[Category:WHO Essential Cancer Medicine]] | [[Category:WHO Essential Cancer Medicine]] | ||
[[Category:WHO Essential Pain and Palliative Care Medicine]] | [[Category:WHO Essential Pain and Palliative Care Medicine]] | ||
Revision as of 23:48, 2 September 2023
General information
Class/mechanism: Corticosteroid & glucocorticoid which has numerous physiologic effects, including immune system modulation, antiemetic properties, and anti-inflammatory effects.[1][2]
Route: PO, IV, IM
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is established (work in progress)
Diseases for which it is used
- Anaplastic large cell lymphoma
- B-cell acute lymphoblastic leukemia
- Burkitt lymphoma
- CNS lymphoma
- Diffuse large B-cell lymphoma
- Extranodal NK- and T-cell lymphoma, nasal type
- Follicular lymphoma
- Hemophagocytic lymphohistiocytosis
- HIV-associated lymphoma
- Classical Hodgkin lymphoma
- Immune thrombocytopenia (ITP)
- Light-chain (AL) amyloidosis
- Mantle cell lymphoma
- Multiple myeloma
- NK- and T-cell lymphoma
- Plasma cell leukemia
- POEMS syndrome
- Primary mediastinal B-cell lymphoma
- Smoldering multiple myeloma
- T-cell acute lymphoblastic leukemia
- Transformed lymphoma
- Waldenström macroglobulinemia
Diseases for which it was used
Patient drug information
- Dexamethasone (Decadron) package insert[1]
- Dexamethasone (Decadron) patient drug information (Chemocare)[3]
- Dexamethasone (Decadron) patient drug information (UpToDate)[4]
History of changes in EMA indication
- 1952-01-01: EURD
History of changes in PMDA indication
- 2010-06-18: New additional indication and a new dosage for the treatment of multiple myeloma.
- 2021-08-25: New indication and a new dosage for the treatment of systemic AL amyloidosis.
Also known as
- Generic names: dexamethasone acetate, dexamethasone sodium, dexamethasone sodium metasulfobenzoate, dexamethasone sodium phosphate, dexamethasone sodium succinate, dexamethasone sodium sulfate
- Brand names:
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| Aacidexam | Acetato DE Dexametasona | Acetazona | Acolon | Adrecort | Adrekon | Aeroseb-DEX | Afpred Forte-Dexa |
| AK-DEX | Aldron | Alfalyl | Alpermell | Amumetazon | Anemul | Aphtasolon | Apidex |
| Arcodexan | Auxiloson | Auxison | Auxisone | B Dexzol | Bexine | Beyonas Dexa | Bisuo DS |
| Brulin | Bucokon | Bufadexon | Butiol | Canalon | Carbidu | Carulon | Cebedex |
| Cellacort | Celudex | Cetadexon | Colircusi Dexametasona | Corodex | Corson | Corsona | Corsone |
| Corsum | Corticoidex | Cortidax | Cortidex | Cortidexason | Cortitop | Coyensu | D-Cort |
| Dacrosone | Daidoron | Dalalone | Danason | Danasone | Daxilone | Decacin | Decaderm |
| Decadolone | Decadran | Decadron | Decadronal | Decadronfosfat | Deca Forte | Decafos | Decalin |
| Decalon | Decalona | Decan | Decans | Decaron | Decason | Decasone | Decaspray |
| Decazol | Decdak | Decdan | Decicort | Decilone | Decobel | Decolite | Decone |
| Decordex | Decorex | Decoron | Decorten | Dectan | Dectancyl | Deexa | Deflaren |
| Dekesu | Dekisachosei | Dekort | Deksa | Deksalon | Deksamet | Dellamethasone | Deltafluorene |
| Demasone | Demeson | Dermadex | Dermidron | Deronil | Deron S | Derson | Dersone |
| Desalark | Desametasone Fosf | Desason | Deson | Detametazon | Detasone | Dethamedin | Dexa |
| Dexabene | Dexabeta | Dexacen-4 | Dexacilin | Dexacip | Dexa Clinit | Dexacollyre | Dexacom |
| Dexacort | Dexacortal | Dexacortin | Dexacortisone | Dexacortisyl | Dexacotsil | Dexacron | Dexacutis |
| Dexaden | Dexaderm | Dexaderme | Dexadermil | Dexadon | Dexadrol | Dexadron | Dexaedo |
| Dexafar | Dexafarm | Dexaflam | Dexaflan | Dexagalen | Dexagee | Dexagel | Dexagenta |
| Dexaglos | Dexagreen | Dexagrin | Dexahexal | Dexaleniens | Dexalocal | Dexaltin | Dexam |
| Dexamag | Dexamark | Dexame | Dexamecortin | Dexamedis | Dexamedix | Dexamedron | Dexameral |
| Dexameson | Dexamesone | Dexamet | Dexametason | Dexametasona | Dexametax | Dexametazon | Dexametazona |
| Dexameth | Dexamethason | Dexamethasonum | Dexamethazon | Dexamethazone | Dexametin | Dexametisona | Dexametonal |
| Dexametrat | Dexamex | Dexamil | Dexamine | Dexaminor | Dexamo | Dexamonozon N | Dexanel |
| Dexan | Dexanil | Dexano | Dexaphos | Dexapolcort | Dexapro | Dexaril | Dexaroid |
| Dexaron | Dexart | Dexasin | Dexasine | Dexasol | Dexasolone | Dexason | Dexasone |
| Dexasonlin | Dexatab | Dexaton | Dexatop | Dexatotal | Dexaval | Dexaven | Dexavet |
| Dexawal | Dexawieb | Dexazen | Dexazona | Dexazone | Dexicorta | Dexin | Dexinga |
| Dexion | Dexmene | Dexmesone | Dexmetha | Dexmethasone | Dexmethsone | Dexona | Dexone |
| Dexonium | Dexoptic | Dexpak | Dexsol | Dexstar | Dextason | Dexthasol | Dexton |
| Dextrasone | Dicorsone | Dicosheun | Diometa | Dison | DM Solone | Donray | Dorison |
| Doronil | Drenex | Drxaline | Elixirmethasone | Epidexone | Epidrone | Erladexone | Ermethasone |
| ETA Cortilen | Etason | Euromethasone | Fada Dexametasona | Fadametasona | Faridexon | Fexadron | Fortecortin |
| Fosfato Dissodico Dexametasona | Gammacorten | Gemisona | Glymesason | Grathazon | Hexadecadrol | Hexadrol | HI-Methasone |
| Hopamethasone | Idizone | Indexon | Inthesa-5 | Irzamethazone | Isodexam | Isopto | Kaarmepakkaus |
| Kalmethasone | Kanadex | Kodolo | Kosa | Kovintong | Lanadexon | Licoson | Limethason |
| Lipotalon | Lisoderme | Lodex | Lodexa | Lokalison-F | Lormine | Loverine | Lupidexa |
| Luxazone | Maradex | Maxidex | Mecoxon | Medesone | Medexasone | Mediamethasone | Medicort |
| Medidex | Megacort | Megadex | Mephameson | Mephamesona | Mephamesone | Mephamesone-4 | Meradexon |
| Merideca | Mesadoron | Metalexina | Metasolon | Metax | Metaxon | Metcort | Methaderm |
| Methasone | Mexasone | Mexaton | Migradexan | Millicorten | Minidex | Mitasone | Molacort |
| Mycidex | Neodex | Nexadron | Nodevex | Nufadex M | Ocedran | Ocudex | Oftadek |
| Oftadex | Omedexon | Onadron | Ophth-DEX | Ophthasona | Opticort | Orazone | Ordex |
| Orgadrone | Penatone | Penodex | Phenodex | Pidexon | Plavex | Plidexa | Prodexon |
| Pyderma | Pyradexon | Rally-A | Randexa | Redexon | Rednisone | Reusan | Rocolone |
| Ronic | Roximeth | Rupedex | Santeson | Sawasone | Scandexon | Selftison | Shirodex |
| Shuayan | Smile | Solcort | Soldesam | Soldesanil | Soldex | Soludecadron | Solupen |
| Sonexa | SP Cordexa | Spersadex | Spondy-Dexa | Stedex | Steralol | Sterasone | Steron |
| Superprednol | Supertendin-Depot N | Suprason | Surodex | Sydencort | Syndexa | Tavesona | Teanlang |
| Teikason Nidek | Tekuron | Thilodex | Thilodexine | Totocortin | Tuttozem N | Ucalon | Udicort |
| Unidex | Unidexa | Unisone | Visualin | Visumetazone | Voalla | Windex | Wymesone |
| Xasone | Xine | Zalucs | Zecaxon | Zenos | Zydexa | Baycadron | ZoDex |
| Neofordex | LenaDex | ||||||
References
Categories:
- Drugs
- Intramuscular medications
- Intravenous medications
- Oral medications
- Steroids
- Anaplastic large cell lymphoma medications
- B-cell acute lymphoblastic leukemia medications
- Burkitt lymphoma medications
- CNS lymphoma medications
- Diffuse large B-cell lymphoma medications
- Extranodal NK- and T-cell lymphoma, nasal type medications
- Follicular lymphoma medications
- Hemophagocytic lymphohistiocytosis medications
- HIV-associated lymphoma medications
- Classical Hodgkin lymphoma medications
- Immune thrombocytopenia medications
- Light-chain (AL) amyloidosis medications
- Mantle cell lymphoma medications
- Multiple myeloma medications
- NK- and T-cell lymphoma medications
- Peripheral T-cell lymphoma medications
- Plasma cell leukemia medications
- POEMS syndrome medications
- Primary mediastinal B-cell lymphoma medications
- Smoldering multiple myeloma medications
- T-cell acute lymphoblastic leukemia medications
- Transformed lymphoma medications
- Waldenström macroglobulinemia medications
- Acute myeloid leukemia medications (historic)
- Prostate cancer medications (historic)
- FDA approved in 1958
- EMA approved in 1952
- WHO Essential Cancer Medicine
- WHO Essential Pain and Palliative Care Medicine