Difference between revisions of "Breast cancer, ER and HER2 co-expressing"
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===References=== | ===References=== | ||
# '''TAnDEM:''' Kaufman B, Mackey JR, Clemens MR, Bapsy PP, Vaid A, Wardley A, Tjulandin S, Jahn M, Lehle M, Feyereislova A, Révil C, Jones A. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol. 2009 Nov 20;27(33):5529-37. Epub 2009 Sep 28. [https://doi.org/10.1200/JCO.2008.20.6847 link to original article] '''contains protocol''' [https://pubmed.ncbi.nlm.nih.gov/19786670 PubMed] NCT00022672 | # '''TAnDEM:''' Kaufman B, Mackey JR, Clemens MR, Bapsy PP, Vaid A, Wardley A, Tjulandin S, Jahn M, Lehle M, Feyereislova A, Révil C, Jones A. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol. 2009 Nov 20;27(33):5529-37. Epub 2009 Sep 28. [https://doi.org/10.1200/JCO.2008.20.6847 link to original article] '''contains protocol''' [https://pubmed.ncbi.nlm.nih.gov/19786670 PubMed] NCT00022672 | ||
+ | |||
+ | ==Anastrozole, Lapatinib, Trastuzumab {{#subobject:gg0dbc|Regimen=1}}== | ||
+ | {| class="wikitable" style="float:right; margin-left: 5px;" | ||
+ | |- | ||
+ | |[[#top|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:ug8a84|Variant=1}}=== | ||
+ | {| class="wikitable sortable" style="width: 100%; text-align:center;" | ||
+ | !style="width: 20%"|Study | ||
+ | !style="width: 20%"|Years of enrollment | ||
+ | !style="width: 20%"|[[Levels_of_Evidence#Evidence|Evidence]] | ||
+ | !style="width: 20%"|Comparator | ||
+ | !style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]] | ||
+ | |- | ||
+ | |rowspan=2|[https://doi.org/10.1200/jco.20.01894 Johnston et al. 2020 (ALTERNATIVE)] | ||
+ | |rowspan=2|2011-2016 | ||
+ | |rowspan=2 style="background-color:#1a9851"|Phase III (E-esc) | ||
+ | |1. Anastrozole & Lapatinib<br> 2. Exemestane & Lapatinib<br> 3. [[#Lapatinib_.26_Letrozole|Lapatinib & Letrozole]] | ||
+ | | style="background-color:#d3d3d3" |Not reported | ||
+ | |- | ||
+ | |4. [[#Anastrozole_.26_Trastuzumab|Anastrozole & Trastuzumab]]<br> 5. [[#Exemestane_.26.Trastuzumab|Exemestane & Trastuzumab]]<br> 6. [[#Letrozole_.26_Trastuzumab|Letrozole & Trastuzumab]] | ||
+ | | style="background-color:#1a9850" |Superior PFS | ||
+ | |- | ||
+ | |} | ||
+ | ''Note: the original article published in 2018 was retracted due to numeric errors in the analysis, and an update has been published.'' | ||
+ | ====Targeted therapy==== | ||
+ | *[[Lapatinib (Tykerb)]] 1000 mg PO once per day | ||
+ | *[[Trastuzumab (Herceptin)]] as follows: | ||
+ | **Cycle 1: 8 mg/kg IV once on day 1 | ||
+ | **Cycle 2 onwards: 6 mg/kg IV once on day 1 | ||
+ | ====Hormonotherapy==== | ||
+ | *[[Anastrozole (Arimidex)]] 1 mg PO once per day | ||
+ | |||
+ | '''21-day cycles''' | ||
+ | |||
+ | ===References=== | ||
+ | <!--- # '''RETRACTED:''' Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD, Kenny S, Sarp S, Izquierdo MA, Williams LS, Gradishar WJ. Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: ALTERNATIVE. J Clin Oncol. 2018 Mar 10;36(8):741-748. Epub 2017 Dec 15. [https://doi.org/10.1200/JCO.2017.74.7824 link to original article] '''contains verified protocol''' [https://pubmed.ncbi.nlm.nih.gov/29244528 PubMed] --> | ||
+ | # '''ALTERNATIVE:''' Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD, Kenny S, Sarp S, Izquierdo MA, Williams LS, Gradishar WJ. Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: Updated Results of ALTERNATIVE. J Clin Oncol. 2021 Jan 1;39(1):79-89. Epub 2020 Aug 21. [https://doi.org/10.1200/jco.20.01894 link to original article] [https://pubmed.ncbi.nlm.nih.gov/32822287 PubMed] NCT01160211 | ||
+ | |||
+ | ==Exemestane, Lapatinib, Trastuzumab {{#subobject:hh0dbc|Regimen=1}}== | ||
+ | {| class="wikitable" style="float:right; margin-left: 5px;" | ||
+ | |- | ||
+ | |[[#top|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:258gja|Variant=1}}=== | ||
+ | {| class="wikitable sortable" style="width: 100%; text-align:center;" | ||
+ | !style="width: 20%"|Study | ||
+ | !style="width: 20%"|Years of enrollment | ||
+ | !style="width: 20%"|[[Levels_of_Evidence#Evidence|Evidence]] | ||
+ | !style="width: 20%"|Comparator | ||
+ | !style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]] | ||
+ | |- | ||
+ | |rowspan=2|[https://doi.org/10.1200/jco.20.01894 Johnston et al. 2020 (ALTERNATIVE)] | ||
+ | |rowspan=2|2011-2016 | ||
+ | |rowspan=2 style="background-color:#1a9851"|Phase III (E-esc) | ||
+ | |1. Anastrozole & Lapatinib<br> 2. Exemestane & Lapatinib<br> 3. [[#Lapatinib_.26_Letrozole|Lapatinib & Letrozole]] | ||
+ | | style="background-color:#d3d3d3" |Not reported | ||
+ | |- | ||
+ | |4. [[#Anastrozole_.26_Trastuzumab|Anastrozole & Trastuzumab]]<br> 5. [[#Exemestane_.26.Trastuzumab|Exemestane & Trastuzumab]]<br> 6. [[#Letrozole_.26_Trastuzumab|Letrozole & Trastuzumab]] | ||
+ | | style="background-color:#1a9850" |Superior PFS | ||
+ | |- | ||
+ | |} | ||
+ | ''Note: the original article published in 2018 was retracted due to numeric errors in the analysis, and an update has been published.'' | ||
+ | ====Targeted therapy==== | ||
+ | *[[Lapatinib (Tykerb)]] 1000 mg PO once per day | ||
+ | *[[Trastuzumab (Herceptin)]] as follows: | ||
+ | **Cycle 1: 8 mg/kg IV once on day 1 | ||
+ | **Cycle 2 onwards: 6 mg/kg IV once on day 1 | ||
+ | ====Hormonotherapy==== | ||
+ | *[[Exemestane (Aromasin)]] 25 mg PO once per day | ||
+ | |||
+ | '''21-day cycles''' | ||
+ | |||
+ | ===References=== | ||
+ | <!--- # '''RETRACTED:''' Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD, Kenny S, Sarp S, Izquierdo MA, Williams LS, Gradishar WJ. Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: ALTERNATIVE. J Clin Oncol. 2018 Mar 10;36(8):741-748. Epub 2017 Dec 15. [https://doi.org/10.1200/JCO.2017.74.7824 link to original article] '''contains verified protocol''' [https://pubmed.ncbi.nlm.nih.gov/29244528 PubMed] --> | ||
+ | # '''ALTERNATIVE:''' Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD, Kenny S, Sarp S, Izquierdo MA, Williams LS, Gradishar WJ. Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: Updated Results of ALTERNATIVE. J Clin Oncol. 2021 Jan 1;39(1):79-89. Epub 2020 Aug 21. [https://doi.org/10.1200/jco.20.01894 link to original article] [https://pubmed.ncbi.nlm.nih.gov/32822287 PubMed] NCT01160211 | ||
==Lapatinib & Letrozole {{#subobject:5fba83|Regimen=1}}== | ==Lapatinib & Letrozole {{#subobject:5fba83|Regimen=1}}== | ||
Line 112: | Line 188: | ||
|- | |- | ||
|rowspan=2|[https://doi.org/10.1200/jco.20.01894 Johnston et al. 2020 (ALTERNATIVE)] | |rowspan=2|[https://doi.org/10.1200/jco.20.01894 Johnston et al. 2020 (ALTERNATIVE)] | ||
− | |rowspan=2| | + | |rowspan=2|2011-2016 |
|rowspan=2 style="background-color:#1a9851"|Phase III (E-esc) | |rowspan=2 style="background-color:#1a9851"|Phase III (E-esc) | ||
− | |1. [[#Lapatinib_.26_Letrozole|Lapatinib & Letrozole]] | + | |1. Anastrozole & Lapatinib<br> 2. Exemestane & Lapatinib<br> 3. [[#Lapatinib_.26_Letrozole|Lapatinib & Letrozole]] |
| style="background-color:#d3d3d3" |Not reported | | style="background-color:#d3d3d3" |Not reported | ||
|- | |- | ||
− | | | + | |4. [[#Anastrozole_.26_Trastuzumab|Anastrozole & Trastuzumab]]<br> 5. [[#Exemestane_.26.Trastuzumab|Exemestane & Trastuzumab]]<br> 6. [[#Letrozole_.26_Trastuzumab|Letrozole & Trastuzumab]] |
| style="background-color:#1a9850" |Superior PFS | | style="background-color:#1a9850" |Superior PFS | ||
|- | |- | ||
|} | |} | ||
− | ''Note: the original article | + | ''Note: the original article published in 2018 was retracted due to numeric errors in the analysis, and an update has been published.'' |
====Targeted therapy==== | ====Targeted therapy==== | ||
*[[Lapatinib (Tykerb)]] 1000 mg PO once per day | *[[Lapatinib (Tykerb)]] 1000 mg PO once per day | ||
Line 133: | Line 209: | ||
===References=== | ===References=== | ||
− | # '''RETRACTED:''' Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD, Kenny S, Sarp S, Izquierdo MA, Williams LS, Gradishar WJ. Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: ALTERNATIVE. J Clin Oncol. 2018 Mar 10;36(8):741-748. Epub 2017 Dec 15. [https://doi.org/10.1200/JCO.2017.74.7824 link to original article] '''contains verified protocol''' [https://pubmed.ncbi.nlm.nih.gov/29244528 PubMed] | + | <!--- # '''RETRACTED:''' Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD, Kenny S, Sarp S, Izquierdo MA, Williams LS, Gradishar WJ. Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: ALTERNATIVE. J Clin Oncol. 2018 Mar 10;36(8):741-748. Epub 2017 Dec 15. [https://doi.org/10.1200/JCO.2017.74.7824 link to original article] '''contains verified protocol''' [https://pubmed.ncbi.nlm.nih.gov/29244528 PubMed] --> |
− | # '''ALTERNATIVE:''' Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD, Kenny S, Sarp S, Izquierdo MA, Williams LS, Gradishar WJ. Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: Updated Results of ALTERNATIVE. J Clin Oncol. 2020 Aug 21 | + | # '''ALTERNATIVE:''' Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD, Kenny S, Sarp S, Izquierdo MA, Williams LS, Gradishar WJ. Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: Updated Results of ALTERNATIVE. J Clin Oncol. 2021 Jan 1;39(1):79-89. Epub 2020 Aug 21. [https://doi.org/10.1200/jco.20.01894 link to original article] [https://pubmed.ncbi.nlm.nih.gov/32822287 PubMed] NCT01160211 |
==Letrozole monotherapy {{#subobject:75d541|Regimen=1}}== | ==Letrozole monotherapy {{#subobject:75d541|Regimen=1}}== |
Revision as of 03:00, 14 February 2021
Section editor transclusions Note: these are regimens tested in patients with hormone receptor-positive, HER2-positive breast cancer. Please see the main breast cancer page, ER+ breast cancer page, and HER2+ breast cancer page for other regimens.
19 regimens on this page
21 variants on this page
|
Metastatic disease, first-line therapy
Anastrozole monotherapy
back to top |
Regimen
Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Kaufman et al. 2009 (TAnDEM) | 2001-2004 | Phase III (C) | Anastrozole & Trastuzumab | Inferior PFS |
Hormonotherapy
- Anastrozole (Arimidex) 1 mg PO once per day
28-day cycles
References
- TAnDEM: Kaufman B, Mackey JR, Clemens MR, Bapsy PP, Vaid A, Wardley A, Tjulandin S, Jahn M, Lehle M, Feyereislova A, Révil C, Jones A. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol. 2009 Nov 20;27(33):5529-37. Epub 2009 Sep 28. link to original article contains protocol PubMed NCT00022672
Anastrozole & Trastuzumab
back to top |
Regimen
Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Kaufman et al. 2009 (TAnDEM) | 2001-2004 | Phase III (E-esc) | Anastrozole | Superior PFS |
Hormonotherapy
- Anastrozole (Arimidex) 1 mg PO once per day
Targeted therapy
- Trastuzumab (Herceptin) as follows:
- Cycle 1: 4 mg/kg IV once on day 1, then 2 mg/kg IV once per day on days 8, 15, 22
- Cycle 2 onwards: 2 mg/kg IV once per day on days 1, 8, 15, 22
28-day cycles
References
- TAnDEM: Kaufman B, Mackey JR, Clemens MR, Bapsy PP, Vaid A, Wardley A, Tjulandin S, Jahn M, Lehle M, Feyereislova A, Révil C, Jones A. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol. 2009 Nov 20;27(33):5529-37. Epub 2009 Sep 28. link to original article contains protocol PubMed NCT00022672
Anastrozole, Lapatinib, Trastuzumab
back to top |
Regimen
Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Johnston et al. 2020 (ALTERNATIVE) | 2011-2016 | Phase III (E-esc) | 1. Anastrozole & Lapatinib 2. Exemestane & Lapatinib 3. Lapatinib & Letrozole |
Not reported |
4. Anastrozole & Trastuzumab 5. Exemestane & Trastuzumab 6. Letrozole & Trastuzumab |
Superior PFS |
Note: the original article published in 2018 was retracted due to numeric errors in the analysis, and an update has been published.
Targeted therapy
- Lapatinib (Tykerb) 1000 mg PO once per day
- Trastuzumab (Herceptin) as follows:
- Cycle 1: 8 mg/kg IV once on day 1
- Cycle 2 onwards: 6 mg/kg IV once on day 1
Hormonotherapy
- Anastrozole (Arimidex) 1 mg PO once per day
21-day cycles
References
- ALTERNATIVE: Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD, Kenny S, Sarp S, Izquierdo MA, Williams LS, Gradishar WJ. Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: Updated Results of ALTERNATIVE. J Clin Oncol. 2021 Jan 1;39(1):79-89. Epub 2020 Aug 21. link to original article PubMed NCT01160211
Exemestane, Lapatinib, Trastuzumab
back to top |
Regimen
Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Johnston et al. 2020 (ALTERNATIVE) | 2011-2016 | Phase III (E-esc) | 1. Anastrozole & Lapatinib 2. Exemestane & Lapatinib 3. Lapatinib & Letrozole |
Not reported |
4. Anastrozole & Trastuzumab 5. Exemestane & Trastuzumab 6. Letrozole & Trastuzumab |
Superior PFS |
Note: the original article published in 2018 was retracted due to numeric errors in the analysis, and an update has been published.
Targeted therapy
- Lapatinib (Tykerb) 1000 mg PO once per day
- Trastuzumab (Herceptin) as follows:
- Cycle 1: 8 mg/kg IV once on day 1
- Cycle 2 onwards: 6 mg/kg IV once on day 1
Hormonotherapy
- Exemestane (Aromasin) 25 mg PO once per day
21-day cycles
References
- ALTERNATIVE: Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD, Kenny S, Sarp S, Izquierdo MA, Williams LS, Gradishar WJ. Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: Updated Results of ALTERNATIVE. J Clin Oncol. 2021 Jan 1;39(1):79-89. Epub 2020 Aug 21. link to original article PubMed NCT01160211
Lapatinib & Letrozole
back to top |
Regimen
Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Johnston et al. 2009 (EGF30008) | 2003-2006 | Phase III (E-RT-esc) | Letrozole | Seems to have superior PFS |
Targeted therapy
- Lapatinib (Tykerb) 1500 mg PO once per day
Hormonotherapy
- Letrozole (Femara) 2.5 mg PO once per day
Continued indefinitely
References
- EGF30008: Johnston S, Pippen J Jr, Pivot X, Lichinitser M, Sadeghi S, Dieras V, Gomez HL, Romieu G, Manikhas A, Kennedy MJ, Press MF, Maltzman J, Florance A, O'Rourke L, Oliva C, Stein S, Pegram M. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol. 2009 Nov 20;27(33):5538-46. Epub 2009 Sep 28. link to original article contains protocol PubMed NCT00073528
Lapatinib, Letrozole, Trastuzumab
back to top |
Regimen
Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Johnston et al. 2020 (ALTERNATIVE) | 2011-2016 | Phase III (E-esc) | 1. Anastrozole & Lapatinib 2. Exemestane & Lapatinib 3. Lapatinib & Letrozole |
Not reported |
4. Anastrozole & Trastuzumab 5. Exemestane & Trastuzumab 6. Letrozole & Trastuzumab |
Superior PFS |
Note: the original article published in 2018 was retracted due to numeric errors in the analysis, and an update has been published.
Targeted therapy
- Lapatinib (Tykerb) 1000 mg PO once per day
- Trastuzumab (Herceptin) as follows:
- Cycle 1: 8 mg/kg IV once on day 1
- Cycle 2 onwards: 6 mg/kg IV once on day 1
Hormonotherapy
- Letrozole (Femara) 2.5 mg PO once per day
21-day cycles
References
- ALTERNATIVE: Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD, Kenny S, Sarp S, Izquierdo MA, Williams LS, Gradishar WJ. Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: Updated Results of ALTERNATIVE. J Clin Oncol. 2021 Jan 1;39(1):79-89. Epub 2020 Aug 21. link to original article PubMed NCT01160211
Letrozole monotherapy
back to top |
Regimen
Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Johnston et al. 2009 (EGF30008) | 2003-2006 | Phase III (C) | Lapatinib & Letrozole | Seems to have inferior PFS |
Hormonotherapy
- Letrozole (Femara) 2.5 mg PO once per day
28-day cycles
References
- EGF30008: Johnston S, Pippen J Jr, Pivot X, Lichinitser M, Sadeghi S, Dieras V, Gomez HL, Romieu G, Manikhas A, Kennedy MJ, Press MF, Maltzman J, Florance A, O'Rourke L, Oliva C, Stein S, Pegram M. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol. 2009 Nov 20;27(33):5538-46. Epub 2009 Sep 28. link to original article contains protocol PubMed NCT00073528