Difference between revisions of "Cisplatin (Platinol)"

Revision as of 03:16, 16 August 2013

General information

Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.^[1]^[2]
Route: IV
Extravasation: vesicant (concentration ≥0.5 mg/mL)/irritant (concentration <0.5 mg/mL)

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Patient drug information

Also known as

Abiplatin, Axiplat, Biocisplatinum, Bioplatino, Blastolem, Blastolem RU, Briplatin, Brisplatin, C-Platin, CDDP, Ceplatin, Ciplatan, Ciplexal, cis-diamminedichloroplatinum III, CIS-GRY, cis-platinum, Cismaplat, Cispatin, Cisplamerck, Cisplan, Cisplasol, Cisplatex, Cisplatin, Cisplatin-AQ, Cisplatin-Ebewe I.A., Cisplatin-Teva, Cisplatin Comp, Cisplatin DBL, Cisplatine, Cisplatin Ebewe, Cisplatine Cytosafe, Cisplatine Dakota, Cisplatine Merck, Cisplatine Teva, Cisplatin FOT, Cisplatin Hexal, Cisplatin Lederle, Cisplatin Lens, Cisplatin Maruko, Cisplatin Mayne, Cisplatin NC, Cisplatino, Cisplatino Almirall, Cisplatino Asofarm, Cisplatino Deltafarma, Cisplatino Ferrer, Cisplatino Gador, Cisplatino Labinca, Cisplatino Martian, Cisplatino Microsules, Cisplatino Pharmacia, Cisplatino Teva, Cisplatin Pharmachemie, Cisplatin Pharmacia, Cisplatin Sandoz, Cisplatin Sanofi-Synthelabo, Cisplatin Solution, Cisplatinum, Cisplatyl, Cisteen, Citoplatino, Cytoplatin, Cytoplatin-AQ, DACP, DDP, Docistin, Elvecis, Fauldcispla, IA COR, Ifapla, JIN Shun, Kemoplat, Lederplatin, Lyoph.cisplatin, Metaplatin, Neoplat, Neoplatin, Nippon Kayaku Cisplatin, Noveldexis, NSC 119875, NUO XIN, Oncoplatin AQ, P&U Cisplatin, Placis, Platamin, Platamine, Platamine RTU, Platiblastin, Platiblastin-S, Platicis, Platidiam, Platikem, Platil, Platimit, Platin, Platinil, Platino II Filaxis, Platinol, Platinol AQ, Platinox, Platinoxan, platinum, Platiran, Platistil, Platistin, Platistine, Platosin, Pronto Platamine, Randa, Romcis, Shun KE DA, Sicatem, Sinplatin, Sisplanil, Tecnoplatin, Tisplal, Trav Cisplatin, or Unistin.

References

[insert-1] 1.0 ^1.1 Cisplatin (Platinol) package insert

[2] Cisplatin (Platinol) package insert (locally hosted backup)

[3] Cisplatin (Platinol) patient drug information (Chemocare)

[4] Cisplatin (Platinol) patient drug information (UpToDate)

[1]

[2]

[3]

[4]

@@ Line 2: / Line 2: @@
 Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018057s080lbl.pdf Cisplatin (Platinol) package insert]</ref><ref>[[Media:Cisplatin.pdf | Cisplatin (Platinol) package insert (locally hosted backup)]]</ref>
 <br>Route: IV
-<br>Extravasation: [[vesicant]] (concentration >=0.5 mg/mL)/[[irritant]] (concentration <0.5 mg/mL)
+<br>Extravasation: [[vesicant]] (concentration ≥0.5 mg/mL)/[[irritant]] (concentration <0.5 mg/mL)
 For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>