Difference between revisions of "Cisplatin (Platinol)"
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| − | Also known as CDDP, cis-diamminedichloroplatinum III, cis-platinum, DACP, DDP, NSC 119875, platinum, Platinol, Platinol-AQ. | + | Also known as CDDP, cis-diamminedichloroplatinum III, cis-platinum, DACP, DDP, NSC 119875, Platin, platinum, Platinol, Platinol-AQ. |
==General information== | ==General information== | ||
| − | Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018057s080lbl.pdf Cisplatin (Platinol) package insert]</ref><ref>[ | + | Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018057s080lbl.pdf Cisplatin (Platinol) package insert]</ref><ref>[[Media:Cisplatin.pdf | Cisplatin (Platinol) package insert (locally hosted backup)]]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[vesicant]] (concentration >=0.5 mg/mL)/[[irritant]] (concentration <0.5 mg/mL) | <br>Extravasation: [[vesicant]] (concentration >=0.5 mg/mL)/[[irritant]] (concentration <0.5 mg/mL) | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Anal cancer]] | ||
| + | *[[Basal cell and squamous cell skin cancer]] | ||
| + | *[[Bladder cancer]] | ||
| + | *[[Bone cancer]] | ||
| + | *[[Cervical cancer]] | ||
| + | *[[Esophageal cancer]] | ||
| + | *[[Gastric cancer]] | ||
| + | *[[Hepatobiliary cancer]] | ||
| + | *[[Hodgkin lymphoma]] | ||
| + | *[[Melanoma]] | ||
| + | *[[Mesothelioma]] | ||
| + | *[[Multiple myeloma]] | ||
| + | *[[Non-small cell lung cancer]] | ||
| + | *[[Ovarian cancer]] | ||
| + | *[[Pancreatic cancer]] | ||
| + | *[[Small cell lung cancer]] | ||
| + | *[[Testicular cancer]] | ||
| + | *[[Thymoma]] | ||
| + | *[[Unknown primary]] | ||
| + | *[[Uterine cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/ | + | *[http://chemocare.com/chemotherapy/drug-info/cisplatin.aspx Cisplatin (Platinol) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/cisplatin.aspx Cisplatin (Platinol) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/cisplatin-patient-drug-information Cisplatin (Platinol) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/cisplatin-patient-drug-information Cisplatin (Platinol) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/cisplatin-patient-drug-information Cisplatin (Platinol) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/cisplatin-patient-drug-information Cisplatin (Platinol) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Platinum agents]] | ||
| + | [[Category:Alkylating agents]] | ||
| + | [[Category:Vesicant chemotherapy]] | ||
| + | [[Category:Irritant chemotherapy]] | ||
| + | [[Category:Anal cancer medications]] | ||
| + | [[Category:Basal cell and squamous cell skin cancer medications]] | ||
| + | [[Category:Bladder cancer medications]] | ||
| + | [[Category:Bone cancer medications]] | ||
| + | [[Category:Cancer of unknown primary medications]] | ||
| + | [[Category:Cervical cancer medications]] | ||
| + | [[Category:Esophageal cancer medications]] | ||
| + | [[Category:Gastric cancer medications]] | ||
| + | [[Category:Hepatobiliary cancer medications]] | ||
| + | [[Category:Hodgkin lymphoma medications]] | ||
| + | [[Category:Melanoma medications]] | ||
| + | [[Category:Mesothelioma medications]] | ||
| + | [[Category:Multiple myeloma medications]] | ||
| + | [[Category:Non-small cell lung cancer medications]] | ||
| + | [[Category:Ovarian cancer medications]] | ||
| + | [[Category:Pancreatic cancer medications]] | ||
| + | [[Category:Small cell lung cancer medications]] | ||
| + | [[Category:Testicular cancer medications]] | ||
| + | [[Category:Thymoma medications]] | ||
| + | [[Category:Uterine cancer medications]] | ||
Revision as of 05:45, 8 October 2012
Also known as CDDP, cis-diamminedichloroplatinum III, cis-platinum, DACP, DDP, NSC 119875, Platin, platinum, Platinol, Platinol-AQ.
General information
Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.[1][2]
Route: IV
Extravasation: vesicant (concentration >=0.5 mg/mL)/irritant (concentration <0.5 mg/mL)
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Anal cancer
- Basal cell and squamous cell skin cancer
- Bladder cancer
- Bone cancer
- Cervical cancer
- Esophageal cancer
- Gastric cancer
- Hepatobiliary cancer
- Hodgkin lymphoma
- Melanoma
- Mesothelioma
- Multiple myeloma
- Non-small cell lung cancer
- Ovarian cancer
- Pancreatic cancer
- Small cell lung cancer
- Testicular cancer
- Thymoma
- Unknown primary
- Uterine cancer
Patient drug information
- Cisplatin (Platinol) patient drug information (Chemocare)[3]
- Cisplatin (Platinol) patient drug information (UpToDate)[4]
References
Categories:
- Drug index
- Chemotherapy
- Platinum agents
- Alkylating agents
- Vesicant chemotherapy
- Irritant chemotherapy
- Anal cancer medications
- Basal cell and squamous cell skin cancer medications
- Bladder cancer medications
- Bone cancer medications
- Cancer of unknown primary medications
- Cervical cancer medications
- Esophageal cancer medications
- Gastric cancer medications
- Hepatobiliary cancer medications
- Hodgkin lymphoma medications
- Melanoma medications
- Mesothelioma medications
- Multiple myeloma medications
- Non-small cell lung cancer medications
- Ovarian cancer medications
- Pancreatic cancer medications
- Small cell lung cancer medications
- Testicular cancer medications
- Thymoma medications
- Uterine cancer medications