Merkel cell carcinoma

From - A Hematology Oncology Wiki
Jump to: navigation, search

Is there a regimen missing from this list? Would you like to share a different dosage/schedule or an additional reference for a regimen? Have you noticed an error? Do you have an idea that will help the site grow to better meet your needs and the needs of many others? You are invited to contribute to the site.

Section editor
Elizabeth Buchbinder, MD
Boston, MA

2 regimens on this page
2 variants on this page



Metastatic or advanced disease, all lines of therapy

Avelumab monotherapy

Source: Avelumab (Bavencio) for merkel cell carcinoma

back to top


Study Evidence ORR
Kaufman et al. 2016 (JAVELIN) Phase II 32% (95% CI: 22–43)


Supportive medications

Per Kaufman et al. 2016 (JAVELIN)

  • H1-antihistamine, such as diphenhydramine (dose & route not given) 30 to 60 minutes prior to each dose of avelumab
  • Paracetamol/acetaminophen (dose not given) 30 to 60 minutes prior to each dose of avelumab
  • The Avelumab package insert suggests "Premedicate with acetaminophen and an antihistamine for the first 4 infusions and subsequently as needed."

14-day cycles


  1. Kaufman HL, Russell J, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbé C, Linette GP, Milella M, Brownell I, Lewis KD, Lorch JH, Chin K, Mahnke L, von Heydebreck A, Cuillerot JM, Nghiem P. Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial. Lancet Oncol. 2016 Oct;17(10):1374-1385. link to original article contains verified protocol PubMed content property of
  2. Abstract: Howard Kaufman, Jeffery Scott Russell, Omid Hamid, Shailender Bhatia, Patrick Terheyden, Sandra P. D'Angelo, Kent C. Shih, Celeste Lebbe, Gerald P Linette, Michele Milella, Isaac Brownell, Karl D. Lewis, Jochen H. Lorch, Kevin M. Chin, Lisa Mahnke, Anja von Heydebreck, Jean-Marie Cuillerot, Paul Nghiem. Avelumab (MSB0010718C; anti-PD-L1) in patients with metastatic Merkel cell carcinoma previously treated with chemotherapy: Results of the phase 2 JAVELIN Merkel 200 trial. 2016 ASCO Annual Meeting abstract 9508. link to abstract

Pembrolizumab monotherapy

back to top


Study Evidence ORR
Nghiem et al. 2016 Phase II 56% (95% CI 35-76%)


21-day cycles for up to 2 years or until CR, progression, or intolerable toxicity


  1. Nghiem PT, Bhatia S, Lipson EJ, Kudchadkar RR, Miller NJ, Annamalai L, Berry S, Chartash EK, Daud A, Fling SP, Friedlander PA, Kluger HM, Kohrt HE, Lundgren L, Margolin K, Mitchell A, Olencki T, Pardoll DM, Reddy SA, Shantha EM, Sharfman WH, Sharon E, Shemanski LR, Shinohara MM, Sunshine JC, Taube JM, Thompson JA, Townson SM, Yearley JH, Topalian SL, Cheever MA. PD-1 blockade with pembrolizumab in advanced Merkel-cell carcinoma. N Engl J Med. 2016 Jun 30;374(26):2542-52. Epub 2016 Apr 19. link to original article link to PMC article contains verified protocol PubMed