Class/mechanism: PD-L1 blocking antibody. PD-L1 (programmed death-1 ligand 1) expressed on tumor cells and tumor-infiltrating immune cells can result in inhibition of anti-tumor immune responses. Durvalumab binds to PD-1 and CD80 (B7.1) receptors on T-cells and antigen presenting cells and prevents PD-L1's inhibitory effects on the immune system. As a result, durvalumab stimulates immune responses, including anti-tumor immune effects. 
Extravasation: no information
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Diseases for which it is used
Diseases for which it was used
Patient drug information
History of changes in FDA indication
- 2/16/2018: FDA approved for patients with unresectable stage III non-small cell lung cancer (NSCLC) whose disease has not progressed following concurrent platinum-based chemotherapy and radiation therapy. (New disease entity; based on PACIFIC)
- 3/27/2020: Approved in combination with etoposide and either carboplatin or cisplatin as first-line treatment of patients with extensive-stage small cell lung cancer (ES-SCLC). (New disease entity; based on CASPIAN)
- 5/1/2017: Granted FDA accelerated approval for the treatment of patients with locally advanced or metastatic urothelial carcinoma who have disease progression during or following platinum-containing chemotherapy (Initial approval)
- 5/1/2017: Granted FDA accelerated approval for the treatment of patients with locally advanced or metastatic urothelial carcinoma who have disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy. (Initial approval)
- 2/22/2021: Indication withdrawn by manufacturer after the confirmatory trial (DANUBE) did not meet its primary endpoints.
Also known as
- Code name: MEDI4736
- Brand name: Imfinzi