Cholangiocarcinoma - historical

The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. Is there a regimen missing from this list? See the main cholangiocarcinoma page for current regimens.

2 regimens on this page 2 variants on this page

Metastatic, first-line therapy

ECF

ECF: Epirubicin, Cisplatin, Fluorouracil

Regimen

Study	Dates of enrollment	Evidence	Comparator	Comparative Efficacy
Rao et al. 2005	1997-2003	Phase 3 (E-switch-ic)	FELV	Did not meet primary endpoint of OS

Chemotherapy

• Epirubicin (Ellence) 50 mg/m² IV once on day 1
• Cisplatin (Platinol) 60 mg/m² IV once on day 1
• Fluorouracil (5-FU) 200 mg/m²/day IV continuous infusion over 21 days, started on day 1 (total dose per cycle: 4200 mg/m²)

21-day cycles

References

1. Rao S, Cunningham D, Hawkins RE, Hill ME, Smith D, Daniel F, Ross PJ, Oates J, Norman AR. Phase III study of 5FU, etoposide and leucovorin (FELV) compared to epirubicin, cisplatin and 5FU (ECF) in previously untreated patients with advanced biliary cancer. Br J Cancer. 2005 May 9;92(9):1650-4. link to original article contains dosing details in manuscript link to PMC article PubMed

FELV

FELV: Fluorouracil , Etoposide & LeucoVorin (Folinic acid)

Regimen

Study	Dates of enrollment	Evidence	Comparator	Comparative Efficacy
Rao et al. 2005	1997-2003	Phase 3 (C)	ECF	Did not meet primary endpoint of OS

Chemotherapy

• Fluorouracil (5-FU) 600 mg/m² IV bolus once per day on days 1 to 3, given first
• Etoposide (Vepesid) 120 mg/m² IV over 40 minutes once per day on days 1 to 3, given second
• Leucovorin (Folinic acid) 60 mg/m² IV bolus once per day on days 1 to 3, given third

21-day cycles

References

1. Rao S, Cunningham D, Hawkins RE, Hill ME, Smith D, Daniel F, Ross PJ, Oates J, Norman AR. Phase III study of 5FU, etoposide and leucovorin (FELV) compared to epirubicin, cisplatin and 5FU (ECF) in previously untreated patients with advanced biliary cancer. Br J Cancer. 2005 May 9;92(9):1650-4. link to original article contains dosing details in manuscript link to PMC article PubMed