Etoposide (Vepesid)

General information

Class/mechanism: Topoisomerase II inhibitor. Causes DNA strand breaks by interacting with DNA-topoisomerase II or by forming free radicals. Causes arrest at the G2 portion of the cell cycle, with dose dependent effects: at high concentrations, cells entering mitosis undergo lysis; at low concentrations, cells are inhibited from entering prophase.^[1]^[2]
Route: IV, PO
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

11/10/1983: Initial FDA approval for refractory testicular tumors

Also known as

Synonyms
Abic Etoposide	Aside	Beposid	Bioposide	BO RUI	Bristol VP-16	Celltop	Citodox
Epocin	Eposid	Eposide	Eposido	Eposin	Epsidox	ETO	Etocris
Etomedac	Etonolver	Etopofos	Etopophos	Etopos	Etoposid	Etoposide Abic	Etoposid Ebewe
Etoposide Bigmar	Etoposide BVI	Etoposide Dakota	Etoposide DBL	Etoposide DUP	Etoposide Ebewe	Etoposide Eurocept	Etoposide Merck
Etoposide Pfizer	etoposide phosphate	Etoposide Teva	Etoposid Mayne	Etoposido	Etoposido Delta Farma	Etoposido Ferrer	Etoposido GI Kendr
Etoposido Servycal	Etoposido Varifarm	Etoposid Proreo	Etoposid Teva	Etopoxan	Etopul	Etosid	Etosin
Eunades CS	Euvaxon	Exitop	Fytop	Fytosid	HAI WEI LIN	Labimion	Lastet
Lastet S	Neoplaxol	Nexvep	Onkoposid	Optasid	P&U Etoposide	Percas	Posid
Posidon	Posyd	Riboposid	Sintopozid	Toposar	Toposide	Toposin	Topresid
Tosuben	Vepefos	Vepeside	Vepesid K	Vepesid S	Vepesid VP-16	Vepsid	Vepside
VP-16	VP-TEC	VP 16213

References

[insert-1] 1.0 ^1.1 Etoposide (Vepesid) package insert

[2] Etoposide (Vepesid) package insert (locally hosted backup)

[3] Etoposide (Vepesid) patient drug information (Chemocare)

[4] Etoposide (Vepesid) patient drug information (UpToDate)

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