Acute lymphoblastic leukemia, infant - historical

The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. Is there a regimen missing from this list? See the main pediatric B-ALL page for current regimens.

1 regimens on this page 1 variants on this page

Induction

Cytarabine, Daunorubicin, L-Asparaginase, Vincristine, Dexamethasone

Regimen

Study	Dates of enrollment	Evidence
Pieters et al. 2007 (Interfant-99)	1999-2005	Non-randomized part of RCT

Note: this regimen is listed as historic primarily due to the unavailability of L-asparaginase.

Preceding treatment

• Prednisone pre-phase

Chemotherapy

• Cytarabine (Ara-C)
• Daunorubicin (Cerubidine)
• Asparaginase (Elspar)
• Vincristine (Oncovin)

Glucocorticoid therapy

• Dexamethasone (Decadron)

Subsequent treatment

• MARAM consolidation

References

1. Interfant-99: Pieters R, Schrappe M, De Lorenzo P, Hann I, De Rossi G, Felice M, Hovi L, LeBlanc T, Szczepanski T, Ferster A, Janka G, Rubnitz J, Silverman L, Stary J, Campbell M, Li CK, Mann G, Suppiah R, Biondi A, Vora A, Valsecchi MG. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial. Lancet. 2007 Jul 21;370(9583):240-250. link to original article PubMed NCT00015873