Asparaginase (Elspar)

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This medication was discontinued by the manufacturer in December 2012, and is now essentially out of stock. Alternatives include Pegaspargase (Oncaspar) or Asparaginase Erwinia chrysanthemi (Erwinaze).

General information

Class/mechanism: Depletes plasma asparagine, selectively killing leukemic cells which are unable to synthesize asparagine due to a lack of asparagine synthetase.[1][2]
Route: IV, IM
Extravasation: neutral

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

Also known as

  • Generic names: colaspase, crisantaspase, L Asparaginase, L-ASP
  • Brand names: Asparaginasa, Chephacardin, Crasnitin, Elspar, Engenase, Kidrolase, Laspar, L Asparaginasa, L Asparaginasum, L-Asperone, L-Ginase, Leucoginase, Leunase, Onconase, Paronal

References

  1. 1.0 1.1 Asparaginase (Elspar) package insert
  2. Asparaginase (Elspar) package insert (locally hosted backup)
  3. Asparaginase (Elspar) patient drug information (Chemocare)
  4. Asparaginase (Elspar) patient drug information (UpToDate)