Acute lymphoblastic leukemia, infant - historical
Revision as of 20:58, 3 November 2023 by Jwarner (talk | contribs) (→Cytarabine, Daunorubicin, L-Asparaginase, Vincristine, Dexamethasone {{#subobject:5a7eda|Regimen=1}})
The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. Is there a regimen missing from this list? See the main pediatric B-ALL page for current regimens.
1 regimens on this page
1 variants on this page
|
Induction
Cytarabine, Daunorubicin, L-Asparaginase, Vincristine, Dexamethasone
Regimen
Study | Dates of enrollment | Evidence |
---|---|---|
Pieters et al. 2007 (Interfant-99) | 1999-2005 | Non-randomized part of RCT |
Pieters et al. 2019 (Interfant-06) | 2006-02 to 2016-07 | Non-randomized part of phase 3 RCT |
Note: this regimen is listed as historic primarily due to the unavailability of L-asparaginase.
Preceding treatment
Chemotherapy
Glucocorticoid therapy
Subsequent treatment
- Interfant-99: MARAM consolidation
- Interfant-06: MARMA versus ADE consolidation
References
- Interfant-99: Pieters R, Schrappe M, De Lorenzo P, Hann I, De Rossi G, Felice M, Hovi L, LeBlanc T, Szczepanski T, Ferster A, Janka G, Rubnitz J, Silverman L, Stary J, Campbell M, Li CK, Mann G, Suppiah R, Biondi A, Vora A, Valsecchi MG. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial. Lancet. 2007 Jul 21;370(9583):240-250. link to original article PubMed NCT00015873
- Interfant-06: Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG. Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study. J Clin Oncol. 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8. link to original article PubMed NCT00550992