Difference between revisions of "B-cell acute lymphoblastic leukemia - historical"
Warner-admin (talk | contribs) m (Text replacement - "{| class="wikitable" style="width: 100%; text-align:center;" !Study !Evidence !Comparator !Efficacy |-" to "{| class="wikitable" style="width: 100%; text-align:center;" !style="width: 25%"|Study !style="width: 25%"|Evidence !style="width: 25%"|Comparator !style="width: 25%"|Efficacy |-") |
|||
Line 67: | Line 67: | ||
|- | |- | ||
|[https://www.thelancet.com/journals/lancet/article/PII0140-6736(91)90733-6/abstract Rivera et al. 1991] | |[https://www.thelancet.com/journals/lancet/article/PII0140-6736(91)90733-6/abstract Rivera et al. 1991] | ||
− | | style="background-color:#91cf61" |Non-randomized | + | | style="background-color:#91cf61" |Non-randomized portion of RCT |
|- | |- | ||
|[https://www.nejm.org/doi/full/10.1056/NEJM199802193380803 Evans et al. 1998] | |[https://www.nejm.org/doi/full/10.1056/NEJM199802193380803 Evans et al. 1998] | ||
Line 80: | Line 80: | ||
*[[Vincristine (Oncovin)]] | *[[Vincristine (Oncovin)]] | ||
*[[Prednisone (Sterapred)]] | *[[Prednisone (Sterapred)]] | ||
+ | ====Subsequent treatment==== | ||
+ | *High-dose MTX | ||
===References=== | ===References=== |
Revision as of 18:25, 20 October 2018
The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. Is there a regimen missing from this list? See the main B-ALL page for current regimens.
11 regimens on this page
13 variants on this page
|
Upfront induction therapy
Aminopterin monotherapy
back to top |
Regimen
Study | Evidence |
---|---|
Farber et al. 1948 | Non-randomized pilot |
Of major historical interest, being the first published cancer chemotherapy experiment in man that led to an active non-clinical-trial intervention (to be distinguished from the trial of diopterin and teropterin published in Science in 1947). This agent is no longer available but was used clinically for several decades.
Chemotherapy
References
- Farber S, Diamond LK, Mercer RD, Sylvester RF, Wolff JA. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N Engl J Med. 1948 Jun 3;238(23):787-93. link to original article PubMed
Cyclophosphamide, Doxorubicin, L-Asparaginase, Vincristine, Prednisolone
back to top |
Regimen
Study | Evidence |
---|---|
Takeuchi et al. 2002 (JALSG-ALL93) | Non-randomized |
Unlikely to be completed, here for historic context only.
Chemotherapy
- Cyclophosphamide (Cytoxan)
- Doxorubicin (Adriamycin)
- L-Asparaginase
- Vincristine (Oncovin)
- Prednisolone (Millipred)
References
- JALSG-ALL93: Takeuchi J, Kyo T, Naito K, Sao H, Takahashi M, Miyawaki S, Kuriyama K, Ohtake S, Yagasaki F, Murakami H, Asou N, Ino T, Okamoto T, Usui N, Nishimura M, Shinagawa K, Fukushima T, Taguchi H, Morii T, Mizuta S, Akiyama H, Nakamura Y, Ohshima T, Ohno R. Induction therapy by frequent administration of doxorubicin with four other drugs, followed by intensive consolidation and maintenance therapy for adult acute lymphoblastic leukemia: the JALSG-ALL93 study. Leukemia. 2002 Jul;16(7):1259-66. link to original article PubMed
Cytarabine, Daunorubicin, L-Asparaginase, Teniposide, Vincristine, Prednisone
back to top |
Regimen
Study | Evidence |
---|---|
Rivera et al. 1991 | Non-randomized portion of RCT |
Evans et al. 1998 | Non-randomized portion of RCT |
Chemotherapy
- Cytarabine (Cytosar)
- Daunorubicin (Cerubidine)
- Asparaginase (Elspar)
- Teniposide (Vumon)
- Vincristine (Oncovin)
- Prednisone (Sterapred)
Subsequent treatment
- High-dose MTX
References
- Rivera GK, Raimondi SC, Hancock ML, Behm FG, Pui CH, Abromowitch M, Mirro J Jr, Ochs JS, Look AT, Williams DL, Hancock ML, Evans WE, Kun LE. Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy. Lancet. 1991 Jan 12;337(8733):61-6. link to original article PubMed
- Evans WE, Relling MV, Rodman JH, Crom WR, Boyett JM, Pui CH. Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia. N Engl J Med. 1998 Feb 19;338(8):499-505. link to original article PubMed
L-Asparaginase, Vincristine, Dexamethasone
back to top |
Regimen
Study | Evidence | Comparator | Efficacy |
---|---|---|---|
Bostrom et al. 2003 (CCG-1922) | Phase III (E) | L-asparaginase, Vincristine, Prednisone | Superior EFS |
Mitchell et al. 2005 (UK MRC ALL97) | Phase III (E) | L-asparaginase, Vincristine, Prednisolone | Superior EFS |
Unlikely to be completed, here for historic context only.
Chemotherapy
References
- CCG-1922: Bostrom BC, Sensel MR, Sather HN, Gaynon PS, La MK, Johnston K, Erdmann GR, Gold S, Heerema NA, Hutchinson RJ, Provisor AJ, Trigg ME; Children's Cancer Group. Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood. 2003 May 15;101(10):3809-17. Epub 2003 Jan 16. link to original article PubMed
- UK MRC ALL97: Mitchell CD, Richards SM, Kinsey SE, Lilleyman J, Vora A, Eden TO; Medical Research Council Childhood Leukaemia Working Party. Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial. Br J Haematol. 2005 Jun;129(6):734-45. link to original article PubMed
L-Asparaginase, Vincristine, Prednisolone
back to top |
Regimen
Study | Evidence | Comparator | Efficacy |
---|---|---|---|
Mitchell et al. 2005 (UK MRC ALL97) | Phase III (C) | L-asparaginase, Vincristine, Dexamethasone | Inferior EFS |
Unlikely to be completed, here for historic context only.
Chemotherapy
References
- UK MRC ALL97: Mitchell CD, Richards SM, Kinsey SE, Lilleyman J, Vora A, Eden TO; Medical Research Council Childhood Leukaemia Working Party. Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial. Br J Haematol. 2005 Jun;129(6):734-45. link to original article PubMed
L-Asparaginase, Vincristine, Prednisone
back to top |
Regimen
Study | Evidence | Comparator | Efficacy |
---|---|---|---|
Gottlieb et al. 1984 | Randomized (C) | Daunorubicin, L-Asparaginase, Vincristine, Prednisone | Inferior CR rate |
van der Does-van den Berg et al. 1989 (DCLSG ALL V) | Phase III (C) | Daunorubicin, L-Asparaginase, Vincristine, Prednisone | Seems not superior |
Bostrom et al. 2003 (CCG-1922) | Phase III (C) | L-asparaginase, Vincristine, Dexamethasone | Inferior EFS |
Unlikely to be completed, here for historic context only.
Chemotherapy
References
- Gottlieb AJ, Weinberg V, Ellison RR, Henderson ES, Terebelo H, Rafla S, Cuttner J, Silver RT, Carey RW, Levy RN, Hutchinson JL, Raich P, Cooper MR, Wiernik P, Anderson JR, Holland JF. Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: a prospective randomized trial by Cancer and Leukemia Group B. Blood. 1984 Jul;64(1):267-74. link to original article PubMed
- DCLSG ALL V: van der Does-van den Berg A, van Wering ER, Suciu S, Solbu G, van 't Veer MB, Rammeloo JA, de Koning J, van Zanen GE. Effectiveness of rubidomycin in induction therapy with vincristine, prednisone, and L-asparaginase for standard risk childhood acute lymphocytic leukemia: results of a Dutch phase III study (ALL V); A report on behalf of the Dutch Childhood Leukemia Study Group (DCLSG). Am J Pediatr Hematol Oncol. 1989 Summer;11(2):125-33. PubMed
- CCG-1922: Bostrom BC, Sensel MR, Sather HN, Gaynon PS, La MK, Johnston K, Erdmann GR, Gold S, Heerema NA, Hutchinson RJ, Provisor AJ, Trigg ME; Children's Cancer Group. Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood. 2003 May 15;101(10):3809-17. Epub 2003 Jan 16. link to original article PubMed
Mercaptopurine & Methotrexate
back to top |
Regimen
Study | Evidence | Comparator | Efficacy |
---|---|---|---|
Frei et al. 1958 | Randomized (E) | 6-MP & MTX (alternate dosing) | Seems not superior |
Note: this is one of the first combination trials in hematology/oncology and possibly the first randomized trial.
Chemotherapy
References
- Frei E 3rd, Holland JF, Schneiderman MA, Pinkel D, Selkirk G, Freireich EJ, Silver RT, Gold GL, Regelson W. A comparative study of two regimens of combination chemotherapy in acute leukemia. Blood. 1958 Dec;13(12):1126-48. link to original article PubMed