Difference between revisions of "Rhabdomyosarcoma, pediatric"
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=Upfront Therapy= | =Upfront Therapy= | ||
+ | |||
==COG ARST0431== | ==COG ARST0431== | ||
− | + | ===IRIN-VCR=== | |
− | ===Vincristine | + | ====Week 1==== |
− | + | *[[Vincristine (Oncovin)]] by the following age-based criteria: | |
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | Administer [[Vincristine (Oncovin)]] before [[Irinotecan (Camptosar)]] | ||
+ | *[[Irinotecan (Camptosar)]] 50 mg/m<sup>2</sup> (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5 | ||
+ | ====Week 2==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 3==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 4==== | ||
*[[Vincristine (Oncovin)]] by the following age-based criteria: | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
**Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
Line 19: | Line 36: | ||
Administer [[Vincristine (Oncovin)]] before [[Irinotecan (Camptosar)]] | Administer [[Vincristine (Oncovin)]] before [[Irinotecan (Camptosar)]] | ||
*[[Irinotecan (Camptosar)]] 50 mg/m<sup>2</sup> (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5 | *[[Irinotecan (Camptosar)]] 50 mg/m<sup>2</sup> (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5 | ||
+ | ====Week 5==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 6==== | ||
+ | *Evaluation Week | ||
− | === | + | ===VDC/IE=== |
− | + | ====Week 7==== | |
*[[Vincristine (Oncovin)]] by the following age-based criteria: | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
**Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
**Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
**Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
− | === | + | *[[Doxorubicin (Adriamycin)]] by the following age-based criteria: |
− | + | **Age ≥ 1 year: 37.5 mg/m<sup>2</sup> (Total dose per week of 75 mg/m<sup>2</sup>) IV over 24 hours once per day on days 1 through 2 | |
− | === | + | **Age < 1 year: 18.75 mg/m<sup>2</sup> IV over 24 hours once per day on days 1 through 2 |
− | + | *[[Cyclophosphamide (Cytoxan)]] by the following age-based criteria: | |
+ | **Age ≥ 3 years: 1200 mg/m<sup>2</sup> IV over 1 hour once per day on day 1 | ||
+ | **Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1 | ||
+ | *[[Mesna (Mesnex)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 240 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | **Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | ====Week 8==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 9==== | ||
+ | *[[Ifosfamide (Ifex)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 1800 mg/m<sup>2</sup> IV over 1 hour once per day on days 1 through 5 | ||
+ | **Age < 1 year: 900 mg/m<sup>2</sup> IV over 1 hour once per day on days 1 through 5 | ||
+ | *[[Mesna (Mesnex)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 360 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Ifosfamide (Ifex)]] infusion on days 1 through 5 | ||
+ | **Age < 3 years: 180 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Ifosfamide (Ifex)]] infusion on days 1 through 5 | ||
+ | *[[Etoposide (Vepesid)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 100 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 through 5 | ||
+ | **Age < 1 year: 50 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 through 5 | ||
+ | ====Week 10==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 11==== | ||
*[[Vincristine (Oncovin)]] by the following age-based criteria: | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
**Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
Line 43: | Line 90: | ||
**Age ≥ 3 years: 240 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | **Age ≥ 3 years: 240 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
**Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | **Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | ====Week 12==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 13==== | ||
+ | *[[Ifosfamide (Ifex)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 1800 mg/m<sup>2</sup> IV over 1 hour once per day on days 1 through 5 | ||
+ | **Age < 1 year: 900 mg/m<sup>2</sup> IV over 1 hour once per day on days 1 through 5 | ||
+ | *[[Mesna (Mesnex)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 360 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Ifosfamide (Ifex)]] infusion on days 1 through 5 | ||
+ | **Age < 3 years: 180 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Ifosfamide (Ifex)]] infusion on days 1 through 5 | ||
+ | *[[Etoposide (Vepesid)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 100 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 through 5 | ||
+ | **Age < 1 year: 50 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 through 5 | ||
+ | ====Week 14==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 15==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | *[[Doxorubicin (Adriamycin)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 37.5 mg/m<sup>2</sup> (Total dose per week of 75 mg/m<sup>2</sup>) IV over 24 hours once per day on days 1 through 2 | ||
+ | **Age < 1 year: 18.75 mg/m<sup>2</sup> IV over 24 hours once per day on days 1 through 2 | ||
+ | *[[Cyclophosphamide (Cytoxan)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1200 mg/m<sup>2</sup> IV over 1 hour once per day on day 1 | ||
+ | **Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1 | ||
+ | *[[Mesna (Mesnex)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 240 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | **Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | ====Week 16==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 17==== | ||
+ | *[[Ifosfamide (Ifex)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 1800 mg/m<sup>2</sup> IV over 1 hour once per day on days 1 through 5 | ||
+ | **Age < 1 year: 900 mg/m<sup>2</sup> IV over 1 hour once per day on days 1 through 5 | ||
+ | *[[Mesna (Mesnex)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 360 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Ifosfamide (Ifex)]] infusion on days 1 through 5 | ||
+ | **Age < 3 years: 180 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Ifosfamide (Ifex)]] infusion on days 1 through 5 | ||
+ | *[[Etoposide (Vepesid)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 100 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 through 5 | ||
+ | **Age < 1 year: 50 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 through 5 | ||
+ | ====Week 18==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 19==== | ||
+ | *Evaluation Week | ||
− | + | ===IRIN-VCR/IE/VDC=== | |
− | ===Ifosfamide and Etoposide=== | + | ====Week 20==== |
− | + | *[[Vincristine (Oncovin)]] by the following age-based criteria: | |
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | Administer [[Vincristine (Oncovin)]] before [[Irinotecan (Camptosar)]] | ||
+ | *[[Irinotecan (Camptosar)]] 50 mg/m<sup>2</sup> (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5 | ||
+ | ====Week 21==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 22==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 23==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | Administer [[Vincristine (Oncovin)]] before [[Irinotecan (Camptosar)]] | ||
+ | *[[Irinotecan (Camptosar)]] 50 mg/m<sup>2</sup> (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5 | ||
+ | ====Week 24==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 25==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 26==== | ||
+ | *[[Ifosfamide (Ifex)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 1800 mg/m<sup>2</sup> IV over 1 hour once per day on days 1 through 5 | ||
+ | **Age < 1 year: 900 mg/m<sup>2</sup> IV over 1 hour once per day on days 1 through 5 | ||
+ | *[[Mesna (Mesnex)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 360 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Ifosfamide (Ifex)]] infusion on days 1 through 5 | ||
+ | **Age < 3 years: 180 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Ifosfamide (Ifex)]] infusion on days 1 through 5 | ||
+ | *[[Etoposide (Vepesid)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 100 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 through 5 | ||
+ | **Age < 1 year: 50 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 through 5 | ||
+ | ====Week 27==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 28==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | *[[Doxorubicin (Adriamycin)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 37.5 mg/m<sup>2</sup> (Total dose per week of 75 mg/m<sup>2</sup>) IV over 24 hours once per day on days 1 through 2 | ||
+ | **Age < 1 year: 18.75 mg/m<sup>2</sup> IV over 24 hours once per day on days 1 through 2 | ||
+ | *[[Cyclophosphamide (Cytoxan)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1200 mg/m<sup>2</sup> IV over 1 hour once per day on day 1 | ||
+ | **Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1 | ||
+ | *[[Mesna (Mesnex)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 240 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | **Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | ====Week 29==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 30==== | ||
*[[Ifosfamide (Ifex)]] by the following age-based criteria: | *[[Ifosfamide (Ifex)]] by the following age-based criteria: | ||
**Age ≥ 1 year: 1800 mg/m<sup>2</sup> IV over 1 hour once per day on days 1 through 5 | **Age ≥ 1 year: 1800 mg/m<sup>2</sup> IV over 1 hour once per day on days 1 through 5 | ||
Line 56: | Line 214: | ||
**Age ≥ 1 year: 100 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 through 5 | **Age ≥ 1 year: 100 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 through 5 | ||
**Age < 1 year: 50 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 through 5 | **Age < 1 year: 50 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 through 5 | ||
+ | ====Week 31==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 32==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | *[[Doxorubicin (Adriamycin)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 37.5 mg/m<sup>2</sup> (Total dose per week of 75 mg/m<sup>2</sup>) IV over 24 hours once per day on days 1 through 2 | ||
+ | **Age < 1 year: 18.75 mg/m<sup>2</sup> IV over 24 hours once per day on days 1 through 2 | ||
+ | *[[Cyclophosphamide (Cytoxan)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1200 mg/m<sup>2</sup> IV over 1 hour once per day on day 1 | ||
+ | **Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1 | ||
+ | *[[Mesna (Mesnex)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 240 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | **Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | ====Week 33==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 34==== | ||
+ | *Evaluation Week | ||
− | === | + | |
− | + | ===VAC/IRIN-VCR=== | |
+ | ====Week 35==== | ||
*[[Vincristine (Oncovin)]] by the following age-based criteria: | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
**Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
Line 72: | Line 254: | ||
**Age ≥ 3 years: 240 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | **Age ≥ 3 years: 240 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
**Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | **Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | ====Week 36==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 37==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 38==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | *[[Dactinomycin (Cosmegen)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 0.045 mg/kg (maximum dose of 2.5 mg) IV push over 1 to 5 minutes once per day on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV over 1 to 5 minutes once per day on day 1 | ||
+ | *[[Cyclophosphamide (Cytoxan)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1200 mg/m<sup>2</sup> IV over 1 hour once per day on day 1 | ||
+ | **Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1 | ||
+ | *[[Mesna (Mesnex)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 240 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | **Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | ====Week 39==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 40==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 41==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | *[[Dactinomycin (Cosmegen)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 0.045 mg/kg (maximum dose of 2.5 mg) IV push over 1 to 5 minutes once per day on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV over 1 to 5 minutes once per day on day 1 | ||
+ | *[[Cyclophosphamide (Cytoxan)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1200 mg/m<sup>2</sup> IV over 1 hour once per day on day 1 | ||
+ | **Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1 | ||
+ | *[[Mesna (Mesnex)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 240 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | **Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | ====Week 42==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 43==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 44==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | *[[Dactinomycin (Cosmegen)]] by the following age-based criteria: | ||
+ | **Age ≥ 1 year: 0.045 mg/kg (maximum dose of 2.5 mg) IV push over 1 to 5 minutes once per day on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV over 1 to 5 minutes once per day on day 1 | ||
+ | *[[Cyclophosphamide (Cytoxan)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1200 mg/m<sup>2</sup> IV over 1 hour once per day on day 1 | ||
+ | **Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1 | ||
+ | *[[Mesna (Mesnex)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 240 mg/m<sup>2</sup> at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | **Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each [[Cyclophosphamide (Cytoxan)]] infusion on days 1 | ||
+ | ====Week 45==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 46==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 47==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | Administer [[Vincristine (Oncovin)]] before [[Irinotecan (Camptosar)]] | ||
+ | *[[Irinotecan (Camptosar)]] 50 mg/m<sup>2</sup> (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5 | ||
+ | ====Week 48==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 49==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 50==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | Administer [[Vincristine (Oncovin)]] before [[Irinotecan (Camptosar)]] | ||
+ | *[[Irinotecan (Camptosar)]] 50 mg/m<sup>2</sup> (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5 | ||
+ | ====Week 51==== | ||
+ | *[[Vincristine (Oncovin)]] by the following age-based criteria: | ||
+ | **Age ≥ 3 years: 1.5 mg/m<sup>2</sup> (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1 | ||
+ | **Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1 | ||
+ | ====Week 52==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 53==== | ||
+ | *Off Chemotherapy Week | ||
+ | ====Week 54==== | ||
+ | *Evaluation Week | ||
+ | |||
====References==== | ====References==== |
Revision as of 22:39, 1 June 2022
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Upfront Therapy
COG ARST0431
IRIN-VCR
Week 1
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Administer Vincristine (Oncovin) before Irinotecan (Camptosar)
- Irinotecan (Camptosar) 50 mg/m2 (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5
Week 2
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 3
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 4
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Administer Vincristine (Oncovin) before Irinotecan (Camptosar)
- Irinotecan (Camptosar) 50 mg/m2 (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5
Week 5
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 6
- Evaluation Week
VDC/IE
Week 7
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
- Doxorubicin (Adriamycin) by the following age-based criteria:
- Age ≥ 1 year: 37.5 mg/m2 (Total dose per week of 75 mg/m2) IV over 24 hours once per day on days 1 through 2
- Age < 1 year: 18.75 mg/m2 IV over 24 hours once per day on days 1 through 2
- Cyclophosphamide (Cytoxan) by the following age-based criteria:
- Age ≥ 3 years: 1200 mg/m2 IV over 1 hour once per day on day 1
- Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 240 mg/m2 at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
- Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
Week 8
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 9
- Ifosfamide (Ifex) by the following age-based criteria:
- Age ≥ 1 year: 1800 mg/m2 IV over 1 hour once per day on days 1 through 5
- Age < 1 year: 900 mg/m2 IV over 1 hour once per day on days 1 through 5
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 360 mg/m2 at hour 0, 4, and 8 from the start of each Ifosfamide (Ifex) infusion on days 1 through 5
- Age < 3 years: 180 mg/m2 at hour 0, 4, and 8 from the start of each Ifosfamide (Ifex) infusion on days 1 through 5
- Etoposide (Vepesid) by the following age-based criteria:
- Age ≥ 1 year: 100 mg/m2 IV over 30 to 60 minutes once per day on days 1 through 5
- Age < 1 year: 50 mg/m2 IV over 30 to 60 minutes once per day on days 1 through 5
Week 10
- Off Chemotherapy Week
Week 11
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
- Doxorubicin (Adriamycin) by the following age-based criteria:
- Age ≥ 1 year: 37.5 mg/m2 (Total dose per week of 75 mg/m2) IV over 24 hours once per day on days 1 through 2
- Age < 1 year: 18.75 mg/m2 IV over 24 hours once per day on days 1 through 2
- Cyclophosphamide (Cytoxan) by the following age-based criteria:
- Age ≥ 3 years: 1200 mg/m2 IV over 1 hour once per day on day 1
- Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 240 mg/m2 at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
- Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
Week 12
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 13
- Ifosfamide (Ifex) by the following age-based criteria:
- Age ≥ 1 year: 1800 mg/m2 IV over 1 hour once per day on days 1 through 5
- Age < 1 year: 900 mg/m2 IV over 1 hour once per day on days 1 through 5
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 360 mg/m2 at hour 0, 4, and 8 from the start of each Ifosfamide (Ifex) infusion on days 1 through 5
- Age < 3 years: 180 mg/m2 at hour 0, 4, and 8 from the start of each Ifosfamide (Ifex) infusion on days 1 through 5
- Etoposide (Vepesid) by the following age-based criteria:
- Age ≥ 1 year: 100 mg/m2 IV over 30 to 60 minutes once per day on days 1 through 5
- Age < 1 year: 50 mg/m2 IV over 30 to 60 minutes once per day on days 1 through 5
Week 14
- Off Chemotherapy Week
Week 15
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
- Doxorubicin (Adriamycin) by the following age-based criteria:
- Age ≥ 1 year: 37.5 mg/m2 (Total dose per week of 75 mg/m2) IV over 24 hours once per day on days 1 through 2
- Age < 1 year: 18.75 mg/m2 IV over 24 hours once per day on days 1 through 2
- Cyclophosphamide (Cytoxan) by the following age-based criteria:
- Age ≥ 3 years: 1200 mg/m2 IV over 1 hour once per day on day 1
- Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 240 mg/m2 at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
- Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
Week 16
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 17
- Ifosfamide (Ifex) by the following age-based criteria:
- Age ≥ 1 year: 1800 mg/m2 IV over 1 hour once per day on days 1 through 5
- Age < 1 year: 900 mg/m2 IV over 1 hour once per day on days 1 through 5
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 360 mg/m2 at hour 0, 4, and 8 from the start of each Ifosfamide (Ifex) infusion on days 1 through 5
- Age < 3 years: 180 mg/m2 at hour 0, 4, and 8 from the start of each Ifosfamide (Ifex) infusion on days 1 through 5
- Etoposide (Vepesid) by the following age-based criteria:
- Age ≥ 1 year: 100 mg/m2 IV over 30 to 60 minutes once per day on days 1 through 5
- Age < 1 year: 50 mg/m2 IV over 30 to 60 minutes once per day on days 1 through 5
Week 18
- Off Chemotherapy Week
Week 19
- Evaluation Week
IRIN-VCR/IE/VDC
Week 20
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Administer Vincristine (Oncovin) before Irinotecan (Camptosar)
- Irinotecan (Camptosar) 50 mg/m2 (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5
Week 21
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 22
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 23
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Administer Vincristine (Oncovin) before Irinotecan (Camptosar)
- Irinotecan (Camptosar) 50 mg/m2 (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5
Week 24
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 25
- Off Chemotherapy Week
Week 26
- Ifosfamide (Ifex) by the following age-based criteria:
- Age ≥ 1 year: 1800 mg/m2 IV over 1 hour once per day on days 1 through 5
- Age < 1 year: 900 mg/m2 IV over 1 hour once per day on days 1 through 5
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 360 mg/m2 at hour 0, 4, and 8 from the start of each Ifosfamide (Ifex) infusion on days 1 through 5
- Age < 3 years: 180 mg/m2 at hour 0, 4, and 8 from the start of each Ifosfamide (Ifex) infusion on days 1 through 5
- Etoposide (Vepesid) by the following age-based criteria:
- Age ≥ 1 year: 100 mg/m2 IV over 30 to 60 minutes once per day on days 1 through 5
- Age < 1 year: 50 mg/m2 IV over 30 to 60 minutes once per day on days 1 through 5
Week 27
- Off Chemotherapy Week
Week 28
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
- Doxorubicin (Adriamycin) by the following age-based criteria:
- Age ≥ 1 year: 37.5 mg/m2 (Total dose per week of 75 mg/m2) IV over 24 hours once per day on days 1 through 2
- Age < 1 year: 18.75 mg/m2 IV over 24 hours once per day on days 1 through 2
- Cyclophosphamide (Cytoxan) by the following age-based criteria:
- Age ≥ 3 years: 1200 mg/m2 IV over 1 hour once per day on day 1
- Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 240 mg/m2 at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
- Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
Week 29
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 30
- Ifosfamide (Ifex) by the following age-based criteria:
- Age ≥ 1 year: 1800 mg/m2 IV over 1 hour once per day on days 1 through 5
- Age < 1 year: 900 mg/m2 IV over 1 hour once per day on days 1 through 5
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 360 mg/m2 at hour 0, 4, and 8 from the start of each Ifosfamide (Ifex) infusion on days 1 through 5
- Age < 3 years: 180 mg/m2 at hour 0, 4, and 8 from the start of each Ifosfamide (Ifex) infusion on days 1 through 5
- Etoposide (Vepesid) by the following age-based criteria:
- Age ≥ 1 year: 100 mg/m2 IV over 30 to 60 minutes once per day on days 1 through 5
- Age < 1 year: 50 mg/m2 IV over 30 to 60 minutes once per day on days 1 through 5
Week 31
- Off Chemotherapy Week
Week 32
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
- Doxorubicin (Adriamycin) by the following age-based criteria:
- Age ≥ 1 year: 37.5 mg/m2 (Total dose per week of 75 mg/m2) IV over 24 hours once per day on days 1 through 2
- Age < 1 year: 18.75 mg/m2 IV over 24 hours once per day on days 1 through 2
- Cyclophosphamide (Cytoxan) by the following age-based criteria:
- Age ≥ 3 years: 1200 mg/m2 IV over 1 hour once per day on day 1
- Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 240 mg/m2 at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
- Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
Week 33
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 34
- Evaluation Week
VAC/IRIN-VCR
Week 35
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
- Dactinomycin (Cosmegen) by the following age-based criteria:
- Age ≥ 1 year: 0.045 mg/kg (maximum dose of 2.5 mg) IV push over 1 to 5 minutes once per day on day 1
- Age < 1 year: 0.025 mg/kg IV over 1 to 5 minutes once per day on day 1
- Cyclophosphamide (Cytoxan) by the following age-based criteria:
- Age ≥ 3 years: 1200 mg/m2 IV over 1 hour once per day on day 1
- Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 240 mg/m2 at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
- Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
Week 36
- Off Chemotherapy Week
Week 37
- Off Chemotherapy Week
Week 38
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
- Dactinomycin (Cosmegen) by the following age-based criteria:
- Age ≥ 1 year: 0.045 mg/kg (maximum dose of 2.5 mg) IV push over 1 to 5 minutes once per day on day 1
- Age < 1 year: 0.025 mg/kg IV over 1 to 5 minutes once per day on day 1
- Cyclophosphamide (Cytoxan) by the following age-based criteria:
- Age ≥ 3 years: 1200 mg/m2 IV over 1 hour once per day on day 1
- Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 240 mg/m2 at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
- Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
Week 39
- Off Chemotherapy Week
Week 40
- Off Chemotherapy Week
Week 41
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
- Dactinomycin (Cosmegen) by the following age-based criteria:
- Age ≥ 1 year: 0.045 mg/kg (maximum dose of 2.5 mg) IV push over 1 to 5 minutes once per day on day 1
- Age < 1 year: 0.025 mg/kg IV over 1 to 5 minutes once per day on day 1
- Cyclophosphamide (Cytoxan) by the following age-based criteria:
- Age ≥ 3 years: 1200 mg/m2 IV over 1 hour once per day on day 1
- Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 240 mg/m2 at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
- Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
Week 42
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 43
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 44
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
- Dactinomycin (Cosmegen) by the following age-based criteria:
- Age ≥ 1 year: 0.045 mg/kg (maximum dose of 2.5 mg) IV push over 1 to 5 minutes once per day on day 1
- Age < 1 year: 0.025 mg/kg IV over 1 to 5 minutes once per day on day 1
- Cyclophosphamide (Cytoxan) by the following age-based criteria:
- Age ≥ 3 years: 1200 mg/m2 IV over 1 hour once per day on day 1
- Age < 3 years: 40mg/kg IV over 1 hour once per day on day 1
- Mesna (Mesnex) by the following age-based criteria:
- Age ≥ 3 years: 240 mg/m2 at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
- Age < 3 years: 8 mg/kg at hour 0, 4, and 8 from the start of each Cyclophosphamide (Cytoxan) infusion on days 1
Week 45
- Off Chemotherapy Week
Week 46
- Off Chemotherapy Week
Week 47
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Administer Vincristine (Oncovin) before Irinotecan (Camptosar)
- Irinotecan (Camptosar) 50 mg/m2 (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5
Week 48
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 49
- Off Chemotherapy Week
Week 50
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Administer Vincristine (Oncovin) before Irinotecan (Camptosar)
- Irinotecan (Camptosar) 50 mg/m2 (maximum dose of 100 mg/day) IV over 60 minutes once per day on days 1 through 5
Week 51
- Vincristine (Oncovin) by the following age-based criteria:
- Age ≥ 3 years: 1.5 mg/m2 (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age ≥ 1 year to < 3 years: 0.05 mg/kg (maximum dose of 2 mg) IV push over 1 minute once on day 1
- Age < 1 year: 0.025 mg/kg IV push over 1 minute once on day 1
Week 52
- Off Chemotherapy Week
Week 53
- Off Chemotherapy Week
Week 54
- Evaluation Week
References
- COG ARST0431: Weigel BJ, Lyden E, Anderson JR, Meyer WH, Parham DM, Rodeberg DA, Michalski JM, Hawkins DS, Arndt CAS. Intensive Multiagent Therapy, Including Dose-Compressed Cycles of Ifosfamide/Etoposide and Vincristine/Doxorubicin/Cyclophosphamide, Irinotecan, and Radiation, in Patients with High-Risk Rhabdomyosarcoma: A Report from the Children's Oncology Group. Journal of Clinical Oncology. 2016 Oct;34(2):117-122. link to original article link to PMC article PubMed NCT00354744