Difference between revisions of "Head and neck cancer - historical"
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!style="width: 25%"|Study | !style="width: 25%"|Study | ||
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CABO: '''<u>C</u>'''isplatin, '''<u>A</u>'''mithopterin (Methotrexate), '''<u>B</u>'''leomycin, '''<u>O</u>'''ncovin (Vincristine) | CABO: '''<u>C</u>'''isplatin, '''<u>A</u>'''mithopterin (Methotrexate), '''<u>B</u>'''leomycin, '''<u>O</u>'''ncovin (Vincristine) | ||
===Regimen {{#subobject:8e0178|Variant=1}}=== | ===Regimen {{#subobject:8e0178|Variant=1}}=== | ||
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!style="width: 20%"|Years of enrollment | !style="width: 20%"|Years of enrollment |
Revision as of 03:01, 26 September 2020
The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. Is there a regimen missing from this list? See the main head and neck cancer page for current regimens.
5 regimens on this page
5 variants on this page
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Locally advanced disease, definitive therapy
Bleomycin, Methotrexate, Vinblastine/RT
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Regimen
Study | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|
Merlano et al. 1988 | Phase III (E-switch-ic) | Bleomycin, MTX, Vinblastine, then RT | Seems to have superior PFS |
Chemotherapy
Radiotherapy
References
- Merlano M, Rosso R, Sertoli MR, Bonelli L, Margarino G, Grimaldi A, Benasso M, Gardin G, Corvó R, Scarpati D, Barbieri A, Pallestrini E, Castiglia G, Santelli A, Scasso F, Bottero G, Ciurlo E, Fracchia P, Moratti M, Santi L. Sequential versus alternating chemotherapy and radiotherapy in stage III-IV squamous cell carcinoma of the head and neck: a phase III study. J Clin Oncol. 1988 Apr;6(4):627-32. link to original article PubMed
Recurrent or metastatic disease, first-line therapy
CABO
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CABO: Cisplatin, Amithopterin (Methotrexate), Bleomycin, Oncovin (Vincristine)
Regimen
Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Clavel et al. 1994 | 1984-1987 | Phase III (C) | 1. CF | Seems to have superior ORR |
2. Cisplatin | Superior ORR |
Chemotherapy
References
- Clavel M, Vermorken JB, Cognetti F, Cappelaere P, de Mulder PH, Schornagel JH, Tueni EA, Verweij J, Wildiers J, Clerico M, Dalesio O, Kirkpatrick A, Snow GB; EORTC Head and Neck Cancer Cooperative Group. Randomized comparison of cisplatin, methotrexate, bleomycin and vincristine (CABO) versus cisplatin and 5-fluorouracil (CF) versus cisplatin (C) in recurrent or metastatic squamous cell carcinoma of the head and neck: a phase III study of the EORTC Head and Neck Cancer Cooperative Group. Ann Oncol. 1994 Jul;5(6):521-6. link to original article contains protocol PubMed