Difference between revisions of "Head and neck cancer - historical"
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!style="width: 25%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]] | !style="width: 25%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]] | ||
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| − | |[https:// | + | |[https://doi.org/10.1200/JCO.1988.6.4.627 Merlano et al. 1988] |
|style="background-color:#1a9851"|Phase III (E-switch-ic) | |style="background-color:#1a9851"|Phase III (E-switch-ic) | ||
|Bleomycin, MTX, Vinblastine, then RT | |Bleomycin, MTX, Vinblastine, then RT | ||
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===References=== | ===References=== | ||
| − | # Merlano M, Rosso R, Sertoli MR, Bonelli L, Margarino G, Grimaldi A, Benasso M, Gardin G, Corvó R, Scarpati D, Barbieri A, Pallestrini E, Castiglia G, Santelli A, Scasso F, Bottero G, Ciurlo E, Fracchia P, Moratti M, Santi L. Sequential versus alternating chemotherapy and radiotherapy in stage III-IV squamous cell carcinoma of the head and neck: a phase III study. J Clin Oncol. 1988 Apr;6(4):627-32. [https:// | + | # Merlano M, Rosso R, Sertoli MR, Bonelli L, Margarino G, Grimaldi A, Benasso M, Gardin G, Corvó R, Scarpati D, Barbieri A, Pallestrini E, Castiglia G, Santelli A, Scasso F, Bottero G, Ciurlo E, Fracchia P, Moratti M, Santi L. Sequential versus alternating chemotherapy and radiotherapy in stage III-IV squamous cell carcinoma of the head and neck: a phase III study. J Clin Oncol. 1988 Apr;6(4):627-32. [https://doi.org/10.1200/JCO.1988.6.4.627 link to original article] [https://pubmed.ncbi.nlm.nih.gov/2451713 PubMed] |
=Recurrent or metastatic disease, first-line therapy= | =Recurrent or metastatic disease, first-line therapy= | ||
Revision as of 15:47, 9 March 2020
The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. Is there a regimen missing from this list? See the main head and neck cancer page for current regimens.
5 regimens on this page
5 variants on this page
|
Locally advanced disease, definitive therapy
Bleomycin, Methotrexate, Vinblastine/RT
| back to top |
Regimen
| Study | Evidence | Comparator | Comparative Efficacy |
|---|---|---|---|
| Merlano et al. 1988 | Phase III (E-switch-ic) | Bleomycin, MTX, Vinblastine, then RT | Seems to have superior PFS |
Chemotherapy
Radiotherapy
References
- Merlano M, Rosso R, Sertoli MR, Bonelli L, Margarino G, Grimaldi A, Benasso M, Gardin G, Corvó R, Scarpati D, Barbieri A, Pallestrini E, Castiglia G, Santelli A, Scasso F, Bottero G, Ciurlo E, Fracchia P, Moratti M, Santi L. Sequential versus alternating chemotherapy and radiotherapy in stage III-IV squamous cell carcinoma of the head and neck: a phase III study. J Clin Oncol. 1988 Apr;6(4):627-32. link to original article PubMed
Recurrent or metastatic disease, first-line therapy
CABO
| back to top |
CABO: Cisplatin, Amithopterin (Methotrexate), Bleomycin, Oncovin (Vincristine)
Regimen
| Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
|---|---|---|---|---|
| Clavel et al. 1994 | 1984-1987 | Phase III (C) | 1. CF | Seems to have superior ORR |
| 2. Cisplatin | Superior ORR |
Chemotherapy
References
- Clavel M, Vermorken JB, Cognetti F, Cappelaere P, de Mulder PH, Schornagel JH, Tueni EA, Verweij J, Wildiers J, Clerico M, Dalesio O, Kirkpatrick A, Snow GB. Randomized comparison of cisplatin, methotrexate, bleomycin and vincristine (CABO) versus cisplatin and 5-fluorouracil (CF) versus cisplatin (C) in recurrent or metastatic squamous cell carcinoma of the head and neck: a phase III study of the EORTC Head and Neck Cancer Cooperative Group. Ann Oncol. 1994 Jul;5(6):521-6. link to original article contains protocol PubMed