Difference between revisions of "Acquired thrombotic thrombocytopenic purpura"
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− | + | [[#top|Back to Top]] | |
− | + | </div> | |
+ | {{#lst:Editorial board transclusions|heme}} | ||
+ | *''We have moved [[How I Treat]] articles to a dedicated page.'' | ||
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− | |<div style="background-color: # | + | |<div style="background-color: #fee0d1; border: 1px solid #808000; padding: 5px; {{border-radius|16px}}" align="right"><font size="4"><b>{{#ask: [[-Has subobject::{{FULLPAGENAME}}]] |?Regimen |limit=10000|format=sum}} [[Tutorial#Regimens|regimens]] on this page</b></font></div> |
− | <div style="background-color: # | + | <div style="background-color: #deebf6; border: 1px solid #808000; padding: 5px; {{border-radius|16px}}"><font size="4"><b>{{#ask: [[-Has subobject::{{FULLPAGENAME}}]] |?Variant |limit=10000|format=sum}} [[Tutorial#Variants|variants]] on this page</b></font></div> |
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{{TOC limit|limit=3}} | {{TOC limit|limit=3}} | ||
+ | =Initial therapy= | ||
+ | ==Caplacizumab & Plasma exchange {{#subobject:4c678d|Regimen=1}}== | ||
+ | <div class="toccolours" style="background-color:#eeeeee"> | ||
+ | ===Regimen {{#subobject:9a4e05|Variant=1}}=== | ||
+ | {| class="wikitable sortable" style="width: 100%; text-align:center;" | ||
+ | !style="width: 20%"|Study | ||
+ | !style="width: 20%"|Dates of enrollment | ||
+ | !style="width: 20%"|[[Levels_of_Evidence#Evidence|Evidence]] | ||
+ | !style="width: 20%"|Comparator | ||
+ | !style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]] | ||
+ | |- | ||
+ | |[https://doi.org/10.1056/NEJMoa1505533 Peyvandi et al. 2016 (TITAN<sub>TTP</sub>)] | ||
+ | |2010-10 to 2014-01 | ||
+ | | style="background-color:#1a9851" |Randomized Phase 2 (E-esc) | ||
+ | |[[#Plasma_exchange|Plasma exchange]] | ||
+ | | style="background-color:#1a9850" |Reduced time to response (primary endpoint) | ||
+ | |- | ||
+ | |[https://doi.org/10.1056/NEJMoa1806311 Scully et al. 2019 (HERCULES)] | ||
+ | |2015-11 to 2017-04 | ||
+ | | style="background-color:#1a9851" |Phase 3 (E-esc) | ||
+ | |[[#Plasma_exchange|Plasma exchange]] | ||
+ | | style="background-color:#1a9850" |Shorter median time to platelet count normalization (primary endpoint)<br><br>Lower composite outcome events (secondary endpoint) | ||
+ | |- | ||
+ | |} | ||
+ | ''Note: there is another trial named TITAN, in NSCLC.'' | ||
+ | <div class="toccolours" style="background-color:#b3e2cd"> | ||
+ | ====Supportive therapy==== | ||
+ | *[[Caplacizumab (Cablivi)]] 10 mg IV once on day 1, then 10 mg SC once per day during plasma exchange and then for 30 additional days | ||
+ | * Plasma exchange with discontinuation of plasma exchange five days after normalization of platelet count. | ||
+ | </div></div> | ||
− | = | + | ===References=== |
+ | # '''TITAN:''' Peyvandi F, Scully M, Kremer Hovinga JA, Cataland S, Knöbl P, Wu H, Artoni A, Westwood JP, Mansouri Taleghani M, Jilma B, Callewaert F, Ulrichts H, Duby C, Tersago D; TITAN Investigators. Caplacizumab for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2016 Feb 11;374(6):511-522. [https://doi.org/10.1056/NEJMoa1505533 link to original article] [https://pubmed.ncbi.nlm.nih.gov/26863353/ PubMed] [https://clinicaltrials.gov/study/NCT01151423 NCT01151423] | ||
+ | # '''HERCULES:''' Scully M, Cataland SR, Peyvandi F, Coppo P, Knöbl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators. Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2019 Jan 24;380(4):335-346. Epub 2019 Jan 9. [https://doi.org/10.1056/NEJMoa1806311 link to original article] '''contains dosing details in abstract''' [https://pubmed.ncbi.nlm.nih.gov/30625070/ PubMed] [https://clinicaltrials.gov/study/NCT02553317 NCT02553317] | ||
==Plasma exchange {{#subobject:4b548d|Regimen=1}}== | ==Plasma exchange {{#subobject:4b548d|Regimen=1}}== | ||
− | + | <div class="toccolours" style="background-color:#eeeeee"> | |
===Regimen {{#subobject:0e1e05|Variant=1}}=== | ===Regimen {{#subobject:0e1e05|Variant=1}}=== | ||
− | {| | + | {| class="wikitable sortable" style="width: 100%; text-align:center;" |
− | | | + | !style="width: 20%"|Study |
− | |[[Levels_of_Evidence#Evidence| | + | !style="width: 20%"|Dates of enrollment |
− | | | + | !style="width: 20%"|[[Levels_of_Evidence#Evidence|Evidence]] |
+ | !style="width: 20%"|Comparator | ||
+ | !style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]] | ||
|- | |- | ||
− | |[ | + | |[https://doi.org/10.1056/NEJM199108083250604 Rock et al. 1991] |
− | | | + | |1982-1989 |
− | style="background:# | + | | style="background-color:#1a9851" |Phase 3 (E-esc) |
− | + | |[[#Plasma_infusion_888|Plasma infusion]] | |
− | + | | style="background-color:#91cf60" |Seems to have superior OS | |
− | |||
− | |||
− | | | ||
|- | |- | ||
|} | |} | ||
− | + | <div class="toccolours" style="background-color:#b3e2cd"> | |
+ | ====Supportive therapy==== | ||
*Total plasma exchange as follows (minimum of 7 treatments in first 9 hospital days): | *Total plasma exchange as follows (minimum of 7 treatments in first 9 hospital days): | ||
**Treatments 1 to 3: Exchange of 1.5 times the predicted plasma volume | **Treatments 1 to 3: Exchange of 1.5 times the predicted plasma volume | ||
− | ** | + | **Treatment 4 onwards: Exchange of 1.0 times the predicted plasma volume |
− | + | ====Supportive therapy==== | |
− | Supportive | ||
*[[Dipyridamole (Persantine)]] 400 mg (route not specified) once per day for at least two weeks | *[[Dipyridamole (Persantine)]] 400 mg (route not specified) once per day for at least two weeks | ||
*[[Aspirin]] 325 mg PO once per day for at least two weeks | *[[Aspirin]] 325 mg PO once per day for at least two weeks | ||
− | + | </div></div> | |
===References=== | ===References=== | ||
− | # Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, Spasoff RA. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura | + | # Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, Spasoff RA; Canadian Apheresis Study Group. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. N Engl J Med. 1991 Aug 8;325(6):393-7. [https://doi.org/10.1056/NEJM199108083250604 link to original article] '''contains dosing details in manuscript''' [https://pubmed.ncbi.nlm.nih.gov/2062330/ PubMed] |
− | + | # '''TITAN:''' Peyvandi F, Scully M, Kremer Hovinga JA, Cataland S, Knöbl P, Wu H, Artoni A, Westwood JP, Mansouri Taleghani M, Jilma B, Callewaert F, Ulrichts H, Duby C, Tersago D; TITAN Investigators. Caplacizumab for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2016 Feb 11;374(6):511-522. [https://doi.org/10.1056/NEJMoa1505533 link to original article] [https://pubmed.ncbi.nlm.nih.gov/26863353/ PubMed] [https://clinicaltrials.gov/study/NCT01151423 NCT01151423] | |
− | + | # '''HERCULES:''' Scully M, Cataland SR, Peyvandi F, Coppo P, Knöbl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators. Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2019 Jan 24;380(4):335-346. Epub 2019 Jan 9. [https://doi.org/10.1056/NEJMoa1806311 link to original article] [https://pubmed.ncbi.nlm.nih.gov/30625070/ PubMed] [https://clinicaltrials.gov/study/NCT02553317 NCT02553317] | |
− | + | =Maintenance/Preemptive treatment= | |
− | '' | + | ==Rituximab monotherapy {{#subobject:4cadec|Regimen=1}}== |
− | + | <div class="toccolours" style="background-color:#eeeeee"> | |
− | == | + | ===Regimen {{#subobject:8bca2c|Variant=1}}=== |
− | {| class="wikitable" style=" | + | {| class="wikitable" style="width: 40%; text-align:center;" |
+ | ! style="width: 50%" |Study | ||
+ | ! style="width: 50%" |[[Levels_of_Evidence#Evidence|Evidence]] | ||
+ | |- | ||
+ | |[https://doi.org/10.1182/blood-2014-01-550244 Hie et al. 2014] | ||
+ | | style="background-color:#91cf61" |Registry | ||
|- | |- | ||
− | |||
|} | |} | ||
− | + | ''Note: this prospective registry trial left precise dosing details to physician discretion.'' | |
− | ===Regimen #1, "High-dose" {{#subobject:0ea120|Variant=1}}=== | + | <div class="toccolours" style="background-color:#b3e2cd"> |
− | {| | + | ====Immunosuppressive therapy==== |
− | | | + | *[[Rituximab (Rituxan)]] |
− | |[[Levels_of_Evidence#Evidence| | + | </div></div> |
− | | | + | ===References=== |
+ | # '''Retrospective:''' Hie M, Gay J, Galicier L, Provôt F, Presne C, Poullin P, Bonmarchand G, Wynckel A, Benhamou Y, Vanhille P, Servais A, Bordessoule D, Coindre JP, Hamidou M, Vernant JP, Veyradier A, Coppo P; French Thrombotic Microangiopathies Reference Centre. Preemptive rituximab infusions after remission efficiently prevent relapses in acquired thrombotic thrombocytopenic purpura. Blood. 2014 Jul 10;124(2):204-10. Epub 2014 May 28. [https://doi.org/10.1182/blood-2014-01-550244 link to original article] [https://pubmed.ncbi.nlm.nih.gov/24869941/ PubMed] | ||
+ | ## '''Update:''' Jestin M, Benhamou Y, Schelpe AS, Roose E, Provôt F, Galicier L, Hié M, Presne C, Poullin P, Wynckel A, Saheb S, Deligny C, Servais A, Girault S, Delmas Y, Kanouni T, Lautrette A, Chauveau D, Mousson C, Perez P, Halimi JM, Charvet-Rumpler A, Hamidou M, Cathébras P, Vanhoorelbeke K, Veyradier A, Coppo P; French Thrombotic Microangiopathies Reference Center. Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura. Blood. 2018 Nov 15;132(20):2143-2153. Epub 2018 Sep 10. [https://doi.org/10.1182/blood-2018-04-840090 link to original article] [https://pubmed.ncbi.nlm.nih.gov/30201758/ PubMed] | ||
+ | =Relapsed or refractory= | ||
+ | ''These treatments are usually used in addition to therapeutic plasma exchange, not in its place. There are also many treatments reported at the case report or case series level.'' | ||
+ | ==Methylprednisolone monotherapy {{#subobject:c31d01|Regimen=1}}== | ||
+ | <div class="toccolours" style="background-color:#eeeeee"> | ||
+ | ===Regimen variant #1, "High-dose" {{#subobject:0ea120|Variant=1}}=== | ||
+ | {| class="wikitable sortable" style="width: 100%; text-align:center;" | ||
+ | !style="width: 20%"|Study | ||
+ | !style="width: 20%"|Dates of enrollment | ||
+ | !style="width: 20%"|[[Levels_of_Evidence#Evidence|Evidence]] | ||
+ | !style="width: 20%"|Comparator | ||
+ | !style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]] | ||
|- | |- | ||
− | |[ | + | |[https://doi.org/10.1007/s00277-009-0877-5 Balduini et al. 2009] |
− | | | + | |2000-2006 |
− | style="background:# | + | | style="background-color:#1a9851" |Phase 3 (E-esc) |
− | + | |[[#Methylprednisolone_monotherapy|Methylprednisolone]]; standard-dose | |
− | + | | style="background-color:#d9ef8b" |Might have superior CR rate | |
− | |||
− | |||
− | | | ||
|- | |- | ||
|} | |} | ||
− | + | <div class="toccolours" style="background-color:#b3e2cd"> | |
− | *[[Methylprednisolone (Solumedrol)]] | + | ====Immunosuppressive therapy==== |
− | + | *[[Methylprednisolone (Solumedrol)]] 10 mg/kg/day IV on days 1 to 3, then 2.5 mg/kg/day IV on days 4 to 23 | |
− | + | '''23-day course''' | |
− | + | </div></div><br> | |
− | ===Regimen #2, "Standard-dose" {{#subobject:84ebef|Variant=1}}=== | + | <div class="toccolours" style="background-color:#eeeeee"> |
− | {| | + | ===Regimen variant #2, "Standard-dose" {{#subobject:84ebef|Variant=1}}=== |
− | | | + | {| class="wikitable sortable" style="width: 100%; text-align:center;" |
− | |[[Levels_of_Evidence#Evidence| | + | !style="width: 20%"|Study |
− | | | + | !style="width: 20%"|Dates of enrollment |
+ | !style="width: 20%"|[[Levels_of_Evidence#Evidence|Evidence]] | ||
+ | !style="width: 20%"|Comparator | ||
+ | !style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]] | ||
|- | |- | ||
− | |[ | + | |[https://doi.org/10.1007/s00277-009-0877-5 Balduini et al. 2009] |
− | | | + | |2000-2006 |
− | style="background:# | + | | style="background-color:#1a9851" |Phase 3 (C) |
− | + | |[[#Methylprednisolone_monotherapy|Methylprednisolone]]; high-dose | |
− | + | | style="background-color:#fee08b" |Might have inferior CR rate | |
− | |||
− | |||
− | | | ||
|- | |- | ||
|} | |} | ||
− | + | <div class="toccolours" style="background-color:#b3e2cd"> | |
− | *[[Methylprednisolone (Solumedrol)]] | + | ====Immunosuppressive therapy==== |
− | + | *[[Methylprednisolone (Solumedrol)]] 1 mg/kg/day IV on days 1 to 3, then 2.5 mg/kg/day IV on days 4 to 23 | |
− | + | '''23-day course''' | |
− | + | </div></div> | |
===References=== | ===References=== | ||
− | # Balduini CL, Gugliotta L, Luppi M, Laurenti L, Klersy C, Pieresca C, Quintini G, Iuliano F, Re R, Spedini P, Vianelli N, Zaccaria A, Pogliani EM, Musso R, Bobbio Pallavicini E, Quarta G, Galieni P, Fragasso A, Casella G, Noris P, Ascari E; Italian TTP Study Group. High versus standard dose methylprednisolone in the acute phase of idiopathic thrombotic thrombocytopenic purpura: a randomized study. Ann Hematol. 2010 Jun;89(6):591-6. Epub 2009 Dec 23. [ | + | # Balduini CL, Gugliotta L, Luppi M, Laurenti L, Klersy C, Pieresca C, Quintini G, Iuliano F, Re R, Spedini P, Vianelli N, Zaccaria A, Pogliani EM, Musso R, Bobbio Pallavicini E, Quarta G, Galieni P, Fragasso A, Casella G, Noris P, Ascari E; Italian TTP Study Group. High versus standard dose methylprednisolone in the acute phase of idiopathic thrombotic thrombocytopenic purpura: a randomized study. Ann Hematol. 2010 Jun;89(6):591-6. Epub 2009 Dec 23. [https://doi.org/10.1007/s00277-009-0877-5 link to original article] '''contains dosing details in abstract''' [https://pubmed.ncbi.nlm.nih.gov/20033409/ PubMed] |
− | ==Rituximab | + | ==Rituximab monotherapy {{#subobject:4cadec|Regimen=1}}== |
− | {| class="wikitable" style=" | + | <div class="toccolours" style="background-color:#eeeeee"> |
+ | ===Regimen variant #1 {{#subobject:8bca2c|Variant=1}}=== | ||
+ | {| class="wikitable sortable" style="width: 60%; text-align:center;" | ||
+ | !style="width: 33%"|Study | ||
+ | !style="width: 33%"|Dates of enrollment | ||
+ | !style="width: 33%"|[[Levels_of_Evidence#Evidence|Evidence]] | ||
|- | |- | ||
− | |[ | + | |[https://doi.org/10.1016/j.transci.2010.09.018 de la Rubia et al. 2010] |
− | | | + | | |
− | + | | style="background-color:#ffffbe" |Retrospective | |
− | |||
− | |||
− | |||
− | | | ||
|- | |- | ||
− | |[ | + | |[https://doi.org/10.1111/bjh.13408 Clark et al. 2015] |
− | | | + | |2008-11-20 to 2012-12-28 |
− | style="background | + | | style="background-color:#91cf61" |Phase 2 |
− | |||
− | |||
− | |||
− | |||
|- | |- | ||
|} | |} | ||
− | + | <div class="toccolours" style="background-color:#b3e2cd"> | |
− | *[[Rituximab (Rituxan)]] 375 mg/ | + | ====Immunosuppressive therapy==== |
− | + | *[[Rituximab (Rituxan)]] 375 mg/m<sup>2</sup> IV once on day 1 | |
− | ''' | + | ====Supportive therapy==== |
− | + | *[[Prednisone (Sterapred)]] 50 mg PO once on day 1, given prior to rituximab | |
− | ===Regimen #2 {{#subobject:a31c78|Variant=1}}=== | + | *[[Diphenhydramine (Benadryl)]] 50 mg PO once on day 1, given prior to rituximab |
− | {| | + | *[[Acetaminophen (Tylenol)]] 325 mg PO once on day 1, given prior to rituximab |
− | | | + | '''7-day cycle for 4 cycles (4-week course)''' |
− | |[[Levels_of_Evidence#Evidence| | + | </div></div><br> |
+ | <div class="toccolours" style="background-color:#eeeeee"> | ||
+ | ===Regimen variant #2 {{#subobject:a31c78|Variant=1}}=== | ||
+ | {| class="wikitable sortable" style="width: 60%; text-align:center;" | ||
+ | !style="width: 33%"|Study | ||
+ | !style="width: 33%"|Dates of enrollment | ||
+ | !style="width: 33%"|[[Levels_of_Evidence#Evidence|Evidence]] | ||
|- | |- | ||
− | |[ | + | |[https://doi.org/10.1097/ccm.0b013e31822e9d66 Froissart et al. 2012] |
− | | | + | |2005-10 to 2008-05 |
− | style="background | + | | style="background-color:#91cf61" |Non-randomized |
− | |||
− | |||
− | |||
− | |||
|- | |- | ||
|} | |} | ||
− | + | <div class="toccolours" style="background-color:#b3e2cd"> | |
− | *[[Rituximab (Rituxan)]] (dose not specified) IV | + | ====Immunosuppressive therapy==== |
− | + | *[[Rituximab (Rituxan)]] (dose not specified) IV for 4 doses (timing not specified) | |
− | ''' | + | '''15-day course''' |
− | + | </div></div> | |
===References=== | ===References=== | ||
− | # de la Rubia J, Moscardó F, Gómez MJ, Guardia R, Rodríguez P, Sebrango A, Zamora C, Debén G, Goterris R, López R, Peña F, Pujol M, Vidaller A, Del Río-Garma J, Sanz MA; Grupo Español de Aféresis. Efficacy and safety of rituximab in adult patients with idiopathic relapsing or refractory thrombotic thrombocytopenic purpura: results of a Spanish multicenter study. Transfus Apher Sci. 2010 Dec;43(3):299-303. Epub 2010 Oct 12. [ | + | # '''Retrospective:''' de la Rubia J, Moscardó F, Gómez MJ, Guardia R, Rodríguez P, Sebrango A, Zamora C, Debén G, Goterris R, López R, Peña F, Pujol M, Vidaller A, Del Río-Garma J, Sanz MA; Grupo Español de Aféresis. Efficacy and safety of rituximab in adult patients with idiopathic relapsing or refractory thrombotic thrombocytopenic purpura: results of a Spanish multicenter study. Transfus Apher Sci. 2010 Dec;43(3):299-303. Epub 2010 Oct 12. [https://doi.org/10.1016/j.transci.2010.09.018 link to original article] '''contains dosing details in abstract''' [https://pubmed.ncbi.nlm.nih.gov/20934383/ PubMed] |
− | # Froissart A, Buffet M, Veyradier A, Poullin P, Provôt F, Malot S, Schwarzinger M, Galicier L, Vanhille P, Vernant JP, Bordessoule D, Guidet B, Azoulay E, Mariotte E, Rondeau E, Mira JP, Wynckel A, Clabault K, Choukroun G, Presne C, Pourrat J, Hamidou M, Coppo P; French Thrombotic Microangiopathies Reference Center. Efficacy and safety of first-line rituximab in severe, acquired thrombotic thrombocytopenic purpura with a suboptimal response to plasma exchange | + | # Froissart A, Buffet M, Veyradier A, Poullin P, Provôt F, Malot S, Schwarzinger M, Galicier L, Vanhille P, Vernant JP, Bordessoule D, Guidet B, Azoulay E, Mariotte E, Rondeau E, Mira JP, Wynckel A, Clabault K, Choukroun G, Presne C, Pourrat J, Hamidou M, Coppo P; French Thrombotic Microangiopathies Reference Center. Efficacy and safety of first-line rituximab in severe, acquired thrombotic thrombocytopenic purpura with a suboptimal response to plasma exchange: experience of the French Thrombotic Microangiopathies Reference Center. Crit Care Med. 2012 Jan;40(1):104-11. [https://doi.org/10.1097/ccm.0b013e31822e9d66 link to original article] [https://pubmed.ncbi.nlm.nih.gov/21926591/ PubMed] |
− | # '''Review:''' Lim W, Vesely SK, George JN. The role of rituximab in the management of patients with acquired thrombotic thrombocytopenic purpura. Blood. 2015 Mar 5;125(10):1526-31. Epub 2015 Jan 8. Review. [ | + | # '''Review:''' Lim W, Vesely SK, George JN. The role of rituximab in the management of patients with acquired thrombotic thrombocytopenic purpura. Blood. 2015 Mar 5;125(10):1526-31. Epub 2015 Jan 8. Review. [https://doi.org/10.1182/blood-2014-10-559211 link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351502/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/25573992/ PubMed] |
− | + | # Clark WF, Rock G, Barth D, Arnold DM, Webert KE, Yenson PR, Kelton JG, Li L, Foley SR; members of the Canadian Apheresis Group. A phase-II sequential case-series study of all patients presenting to four plasma exchange centres with presumed relapsed/refractory thrombotic thrombocytopenic purpura treated with rituximab. Br J Haematol. 2015 Jul;170(2):208-17. Epub 2015 Apr 8. [https://doi.org/10.1111/bjh.13408 link to original article] '''contains dosing details in manuscript''' [https://pubmed.ncbi.nlm.nih.gov/25855259/ PubMed] | |
− | ==Vincristine | + | ==Vincristine monotherapy {{#subobject:583bc2|Regimen=1}}== |
− | + | <div class="toccolours" style="background-color:#eeeeee"> | |
− | |||
− | |||
− | |||
− | |||
===Regimen {{#subobject:8892fc|Variant=1}}=== | ===Regimen {{#subobject:8892fc|Variant=1}}=== | ||
− | {| | + | {| class="wikitable sortable" style="width: 60%; text-align:center;" |
− | | | + | !style="width: 33%"|Study |
− | |[[Levels_of_Evidence#Evidence| | + | !style="width: 33%"|Dates of enrollment |
+ | !style="width: 33%"|[[Levels_of_Evidence#Evidence|Evidence]] | ||
|- | |- | ||
− | |[ | + | |[https://doi.org/10.1007/s002770050549 Ferrara et al. 1999] |
− | | | + | |NR |
− | style="background | + | | style="background-color:#ffffbe" |Pilot, fewer than 20 patients |
− | |||
− | |||
− | |||
− | |||
|- | |- | ||
|} | |} | ||
− | + | <div class="toccolours" style="background-color:#b3e2cd"> | |
− | *[[Vincristine (Oncovin)]] | + | ====Chemotherapy==== |
− | + | *[[Vincristine (Oncovin)]] 1.4 mg/m<sup>2</sup> IV once on day 1, then 1 mg IV once per day on days 4 & 7 | |
− | + | </div></div> | |
− | |||
===References=== | ===References=== | ||
− | # Ferrara F, Copia C, Annunziata M, Spasiano A, Di Grazia C, Palmieri S, Prossomariti L, Mele G. Vincristine as salvage treatment for refractory thrombotic thrombocytopenic purpura. Ann Hematol. 1999 Nov;78(11):521-3. '''contains | + | # Ferrara F, Copia C, Annunziata M, Spasiano A, Di Grazia C, Palmieri S, Prossomariti L, Mele G. Vincristine as salvage treatment for refractory thrombotic thrombocytopenic purpura. Ann Hematol. 1999 Nov;78(11):521-3. [https://doi.org/10.1007/s002770050549 link to original article] '''contains dosing details in abstract''' [https://pubmed.ncbi.nlm.nih.gov/10602896/ PubMed] |
+ | [[Category:Acquired thrombotic thrombocytopenic purpura regimens]] | ||
+ | [[Category:Disease-specific pages]] | ||
+ | [[Category:Autoimmune hematologic conditions]] | ||
+ | [[Category:Cytopenias]] | ||
+ | [[Category:Thrombotic disorders]] |
Latest revision as of 00:38, 27 June 2024
Section editor | |
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Benjamin Tillman, MD Vanderbilt University Nashville, TN, USA |
- We have moved How I Treat articles to a dedicated page.
5 regimens on this page
7 variants on this page
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Initial therapy
Caplacizumab & Plasma exchange
Regimen
Study | Dates of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Peyvandi et al. 2016 (TITANTTP) | 2010-10 to 2014-01 | Randomized Phase 2 (E-esc) | Plasma exchange | Reduced time to response (primary endpoint) |
Scully et al. 2019 (HERCULES) | 2015-11 to 2017-04 | Phase 3 (E-esc) | Plasma exchange | Shorter median time to platelet count normalization (primary endpoint) Lower composite outcome events (secondary endpoint) |
Note: there is another trial named TITAN, in NSCLC.
Supportive therapy
- Caplacizumab (Cablivi) 10 mg IV once on day 1, then 10 mg SC once per day during plasma exchange and then for 30 additional days
- Plasma exchange with discontinuation of plasma exchange five days after normalization of platelet count.
References
- TITAN: Peyvandi F, Scully M, Kremer Hovinga JA, Cataland S, Knöbl P, Wu H, Artoni A, Westwood JP, Mansouri Taleghani M, Jilma B, Callewaert F, Ulrichts H, Duby C, Tersago D; TITAN Investigators. Caplacizumab for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2016 Feb 11;374(6):511-522. link to original article PubMed NCT01151423
- HERCULES: Scully M, Cataland SR, Peyvandi F, Coppo P, Knöbl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators. Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2019 Jan 24;380(4):335-346. Epub 2019 Jan 9. link to original article contains dosing details in abstract PubMed NCT02553317
Plasma exchange
Regimen
Study | Dates of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Rock et al. 1991 | 1982-1989 | Phase 3 (E-esc) | Plasma infusion | Seems to have superior OS |
Supportive therapy
- Total plasma exchange as follows (minimum of 7 treatments in first 9 hospital days):
- Treatments 1 to 3: Exchange of 1.5 times the predicted plasma volume
- Treatment 4 onwards: Exchange of 1.0 times the predicted plasma volume
Supportive therapy
- Dipyridamole (Persantine) 400 mg (route not specified) once per day for at least two weeks
- Aspirin 325 mg PO once per day for at least two weeks
References
- Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, Spasoff RA; Canadian Apheresis Study Group. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. N Engl J Med. 1991 Aug 8;325(6):393-7. link to original article contains dosing details in manuscript PubMed
- TITAN: Peyvandi F, Scully M, Kremer Hovinga JA, Cataland S, Knöbl P, Wu H, Artoni A, Westwood JP, Mansouri Taleghani M, Jilma B, Callewaert F, Ulrichts H, Duby C, Tersago D; TITAN Investigators. Caplacizumab for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2016 Feb 11;374(6):511-522. link to original article PubMed NCT01151423
- HERCULES: Scully M, Cataland SR, Peyvandi F, Coppo P, Knöbl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators. Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2019 Jan 24;380(4):335-346. Epub 2019 Jan 9. link to original article PubMed NCT02553317
Maintenance/Preemptive treatment
Rituximab monotherapy
Regimen
Study | Evidence |
---|---|
Hie et al. 2014 | Registry |
Note: this prospective registry trial left precise dosing details to physician discretion.
Immunosuppressive therapy
References
- Retrospective: Hie M, Gay J, Galicier L, Provôt F, Presne C, Poullin P, Bonmarchand G, Wynckel A, Benhamou Y, Vanhille P, Servais A, Bordessoule D, Coindre JP, Hamidou M, Vernant JP, Veyradier A, Coppo P; French Thrombotic Microangiopathies Reference Centre. Preemptive rituximab infusions after remission efficiently prevent relapses in acquired thrombotic thrombocytopenic purpura. Blood. 2014 Jul 10;124(2):204-10. Epub 2014 May 28. link to original article PubMed
- Update: Jestin M, Benhamou Y, Schelpe AS, Roose E, Provôt F, Galicier L, Hié M, Presne C, Poullin P, Wynckel A, Saheb S, Deligny C, Servais A, Girault S, Delmas Y, Kanouni T, Lautrette A, Chauveau D, Mousson C, Perez P, Halimi JM, Charvet-Rumpler A, Hamidou M, Cathébras P, Vanhoorelbeke K, Veyradier A, Coppo P; French Thrombotic Microangiopathies Reference Center. Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura. Blood. 2018 Nov 15;132(20):2143-2153. Epub 2018 Sep 10. link to original article PubMed
Relapsed or refractory
These treatments are usually used in addition to therapeutic plasma exchange, not in its place. There are also many treatments reported at the case report or case series level.
Methylprednisolone monotherapy
Regimen variant #1, "High-dose"
Study | Dates of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Balduini et al. 2009 | 2000-2006 | Phase 3 (E-esc) | Methylprednisolone; standard-dose | Might have superior CR rate |
Immunosuppressive therapy
- Methylprednisolone (Solumedrol) 10 mg/kg/day IV on days 1 to 3, then 2.5 mg/kg/day IV on days 4 to 23
23-day course
Regimen variant #2, "Standard-dose"
Study | Dates of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Balduini et al. 2009 | 2000-2006 | Phase 3 (C) | Methylprednisolone; high-dose | Might have inferior CR rate |
Immunosuppressive therapy
- Methylprednisolone (Solumedrol) 1 mg/kg/day IV on days 1 to 3, then 2.5 mg/kg/day IV on days 4 to 23
23-day course
References
- Balduini CL, Gugliotta L, Luppi M, Laurenti L, Klersy C, Pieresca C, Quintini G, Iuliano F, Re R, Spedini P, Vianelli N, Zaccaria A, Pogliani EM, Musso R, Bobbio Pallavicini E, Quarta G, Galieni P, Fragasso A, Casella G, Noris P, Ascari E; Italian TTP Study Group. High versus standard dose methylprednisolone in the acute phase of idiopathic thrombotic thrombocytopenic purpura: a randomized study. Ann Hematol. 2010 Jun;89(6):591-6. Epub 2009 Dec 23. link to original article contains dosing details in abstract PubMed
Rituximab monotherapy
Regimen variant #1
Study | Dates of enrollment | Evidence |
---|---|---|
de la Rubia et al. 2010 | Retrospective | |
Clark et al. 2015 | 2008-11-20 to 2012-12-28 | Phase 2 |
Immunosuppressive therapy
- Rituximab (Rituxan) 375 mg/m2 IV once on day 1
Supportive therapy
- Prednisone (Sterapred) 50 mg PO once on day 1, given prior to rituximab
- Diphenhydramine (Benadryl) 50 mg PO once on day 1, given prior to rituximab
- Acetaminophen (Tylenol) 325 mg PO once on day 1, given prior to rituximab
7-day cycle for 4 cycles (4-week course)
Regimen variant #2
Study | Dates of enrollment | Evidence |
---|---|---|
Froissart et al. 2012 | 2005-10 to 2008-05 | Non-randomized |
Immunosuppressive therapy
- Rituximab (Rituxan) (dose not specified) IV for 4 doses (timing not specified)
15-day course
References
- Retrospective: de la Rubia J, Moscardó F, Gómez MJ, Guardia R, Rodríguez P, Sebrango A, Zamora C, Debén G, Goterris R, López R, Peña F, Pujol M, Vidaller A, Del Río-Garma J, Sanz MA; Grupo Español de Aféresis. Efficacy and safety of rituximab in adult patients with idiopathic relapsing or refractory thrombotic thrombocytopenic purpura: results of a Spanish multicenter study. Transfus Apher Sci. 2010 Dec;43(3):299-303. Epub 2010 Oct 12. link to original article contains dosing details in abstract PubMed
- Froissart A, Buffet M, Veyradier A, Poullin P, Provôt F, Malot S, Schwarzinger M, Galicier L, Vanhille P, Vernant JP, Bordessoule D, Guidet B, Azoulay E, Mariotte E, Rondeau E, Mira JP, Wynckel A, Clabault K, Choukroun G, Presne C, Pourrat J, Hamidou M, Coppo P; French Thrombotic Microangiopathies Reference Center. Efficacy and safety of first-line rituximab in severe, acquired thrombotic thrombocytopenic purpura with a suboptimal response to plasma exchange: experience of the French Thrombotic Microangiopathies Reference Center. Crit Care Med. 2012 Jan;40(1):104-11. link to original article PubMed
- Review: Lim W, Vesely SK, George JN. The role of rituximab in the management of patients with acquired thrombotic thrombocytopenic purpura. Blood. 2015 Mar 5;125(10):1526-31. Epub 2015 Jan 8. Review. link to original article link to PMC article PubMed
- Clark WF, Rock G, Barth D, Arnold DM, Webert KE, Yenson PR, Kelton JG, Li L, Foley SR; members of the Canadian Apheresis Group. A phase-II sequential case-series study of all patients presenting to four plasma exchange centres with presumed relapsed/refractory thrombotic thrombocytopenic purpura treated with rituximab. Br J Haematol. 2015 Jul;170(2):208-17. Epub 2015 Apr 8. link to original article contains dosing details in manuscript PubMed
Vincristine monotherapy
Regimen
Study | Dates of enrollment | Evidence |
---|---|---|
Ferrara et al. 1999 | NR | Pilot, fewer than 20 patients |
Chemotherapy
- Vincristine (Oncovin) 1.4 mg/m2 IV once on day 1, then 1 mg IV once per day on days 4 & 7
References
- Ferrara F, Copia C, Annunziata M, Spasiano A, Di Grazia C, Palmieri S, Prossomariti L, Mele G. Vincristine as salvage treatment for refractory thrombotic thrombocytopenic purpura. Ann Hematol. 1999 Nov;78(11):521-3. link to original article contains dosing details in abstract PubMed