Difference between revisions of "Acute lymphoblastic leukemia, infant - historical"
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|1999-2005 | |1999-2005 | ||
| style="background-color:#91cf61" |Non-randomized part of RCT | | style="background-color:#91cf61" |Non-randomized part of RCT | ||
| + | |- | ||
| + | |[https://doi.org/10.1200/jco.19.00261 Pieters et al. 2019 (Interfant-06)] | ||
| + | |2006-02 to 2016-07 | ||
| + | | style="background-color:#91cf61" |Non-randomized part of phase 3 RCT | ||
|- | |- | ||
|} | |} | ||
| Line 42: | Line 46: | ||
<div class="toccolours" style="background-color:#cbd5e7"> | <div class="toccolours" style="background-color:#cbd5e7"> | ||
====Subsequent treatment==== | ====Subsequent treatment==== | ||
| − | *MARAM consolidation | + | *Interfant-99: MARAM consolidation |
| + | *Interfant-06: MARMA versus ADE consolidation | ||
</div></div> | </div></div> | ||
===References=== | ===References=== | ||
# '''Interfant-99:''' Pieters R, Schrappe M, De Lorenzo P, Hann I, De Rossi G, Felice M, Hovi L, LeBlanc T, Szczepanski T, Ferster A, Janka G, Rubnitz J, Silverman L, Stary J, Campbell M, Li CK, Mann G, Suppiah R, Biondi A, Vora A, Valsecchi MG. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial. Lancet. 2007 Jul 21;370(9583):240-250. [https://doi.org/10.1016/s0140-6736(07)61126-x link to original article] [https://pubmed.ncbi.nlm.nih.gov/17658395/ PubMed] [https://clinicaltrials.gov/study/NCT00015873 NCT00015873] | # '''Interfant-99:''' Pieters R, Schrappe M, De Lorenzo P, Hann I, De Rossi G, Felice M, Hovi L, LeBlanc T, Szczepanski T, Ferster A, Janka G, Rubnitz J, Silverman L, Stary J, Campbell M, Li CK, Mann G, Suppiah R, Biondi A, Vora A, Valsecchi MG. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial. Lancet. 2007 Jul 21;370(9583):240-250. [https://doi.org/10.1016/s0140-6736(07)61126-x link to original article] [https://pubmed.ncbi.nlm.nih.gov/17658395/ PubMed] [https://clinicaltrials.gov/study/NCT00015873 NCT00015873] | ||
| + | # '''Interfant-06:''' Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG. Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study. J Clin Oncol. 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8. [https://doi.org/10.1200/jco.19.00261 link to original article] [https://pubmed.ncbi.nlm.nih.gov/31283407/ PubMed] [https://clinicaltrials.gov/study/NCT00550992 NCT00550992] | ||
[[Category:Acute lymphoblastic leukemia, infant regimens]] | [[Category:Acute lymphoblastic leukemia, infant regimens]] | ||
Revision as of 20:58, 3 November 2023
The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. Is there a regimen missing from this list? See the main pediatric B-ALL page for current regimens.
1 regimens on this page
1 variants on this page
|
Induction
Cytarabine, Daunorubicin, L-Asparaginase, Vincristine, Dexamethasone
Regimen
| Study | Dates of enrollment | Evidence |
|---|---|---|
| Pieters et al. 2007 (Interfant-99) | 1999-2005 | Non-randomized part of RCT |
| Pieters et al. 2019 (Interfant-06) | 2006-02 to 2016-07 | Non-randomized part of phase 3 RCT |
Note: this regimen is listed as historic primarily due to the unavailability of L-asparaginase.
Preceding treatment
Chemotherapy
Glucocorticoid therapy
Subsequent treatment
- Interfant-99: MARAM consolidation
- Interfant-06: MARMA versus ADE consolidation
References
- Interfant-99: Pieters R, Schrappe M, De Lorenzo P, Hann I, De Rossi G, Felice M, Hovi L, LeBlanc T, Szczepanski T, Ferster A, Janka G, Rubnitz J, Silverman L, Stary J, Campbell M, Li CK, Mann G, Suppiah R, Biondi A, Vora A, Valsecchi MG. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial. Lancet. 2007 Jul 21;370(9583):240-250. link to original article PubMed NCT00015873
- Interfant-06: Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG. Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study. J Clin Oncol. 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8. link to original article PubMed NCT00550992