Difference between revisions of "Mitoxantrone (Novantrone)"

Revision as of 03:13, 20 September 2021

General information

Class/mechanism: Synthetic antineoplastic anthracenedione, intercalates into DNA, causing crosslinking and strand breaks. Mitoxantrone inhibits topoisomerase II, which helps to uncoil and repair damaged DNA. It also has been observed to interfere with RNA and has activity against resting and proliferating cells. In vitro, it has been observed to interfere with antigen presentation; inhibit B-cell, T-cell, and macrophage proliferation; and decrease secretion of interferon gamma, tumor necrosis factor-alpha (TNF-α), and interleukin-2 (IL-2).^[1]^[2]
Route: IV
Extravasation: irritant (usually), vesicant (rare)

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Diseases for which it was used

Breast cancer

Patient drug information

History of changes in FDA indication

12/23/1987: Initial FDA approval for the initial therapy of acute nonlymphocytic leukemia (ANLL) in adults. This category includes myelogenous, promyelocytic, monocytic, and erythroid acute leukemias
11/13/1996: Approved in combination with corticosteroids as initial chemotherapy for the treatment of patients with pain related to advanced hormone-refractory prostate cancer.

Also known as

Generic name: mitozantrone
Brand names: Nitrol, Novantron, Novantrone

References

[insert-1] 1.0 ^1.1 Mitoxantrone (Novantrone) package insert

[2] Mitoxantrone (Novantrone) package insert (locally hosted backup)

[3] Mitoxantrone (Novantrone) patient drug information (Chemocare)

[4] Mitoxantrone (Novantrone) patient drug information (UpToDate)

[1]

[2]

[3]

[4]

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 ==General information==
-Class/mechanism: Synthetic antineoplastic anthracenedione, intercalates into DNA, causing crosslinking and strand breaks.  Mitoxantrone inhibits topoisomerase II, which helps to uncoil and repair damaged DNA.  It also has been observed to interfere with RNA and has activity against resting and proliferating cells.  In vitro, it has been observed to interfere with antigen presentation; inhibit B-cell, T-cell, and macrophage proliferation; and decrease secretion of interferon gamma, tumor necrosis factor-alpha (TNF-α), and interleukin-2 (IL-2).<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019297s035lbl.pdf Mitoxantrone (Novantrone) package insert]</ref><ref>[[File:Mitoxantrone.pdf | Mitoxantrone (Novantrone) package insert (locally hosted backup)]]</ref>
+Class/mechanism: Synthetic antineoplastic anthracenedione, intercalates into DNA, causing crosslinking and strand breaks.  Mitoxantrone inhibits topoisomerase II, which helps to uncoil and repair damaged DNA.  It also has been observed to interfere with RNA and has activity against resting and proliferating cells.  In vitro, it has been observed to interfere with antigen presentation; inhibit B-cell, T-cell, and macrophage proliferation; and decrease secretion of interferon gamma, tumor necrosis factor-alpha (TNF-α), and interleukin-2 (IL-2).<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019297s035lbl.pdf Mitoxantrone (Novantrone) package insert]</ref><ref>[[:File:Mitoxantrone.pdf | Mitoxantrone (Novantrone) package insert (locally hosted backup)]]</ref>
 <br>Route: IV
 <br>Extravasation: [[irritant]] (usually), [[vesicant]] (rare)