Difference between revisions of "Docetaxel (Taxotere)"

From HemOnc.org - A Hematology Oncology Wiki
Jump to navigation Jump to search
m
m
Line 5: Line 5:
  
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>  
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>  
 +
 +
==Diseases for which it is used==
 +
*[[Bone cancer]]
 +
*[[Breast cancer]]
 +
*[[Cervical cancer]]
 +
*[[Esophageal cancer]]
 +
*[[Gastric cancer]]
 +
*[[Head and neck cancer]]
 +
*[[Melanoma]]
 +
*[[Non-small cell lung cancer]]
 +
*[[Ovarian cancer]]
 +
*[[Pancreatic cancer]]
 +
*[[Prostate cancer]]
 +
*[[Sarcoma]]
 +
*[[Small cell lung cancer]]
 +
*[[Unknown primary]]
  
 
==Patient drug information==
 
==Patient drug information==
Line 10: Line 26:
 
*[http://products.sanofi.us/taxotere/taxotere.pdf#page=16 Docetaxel (Taxotere) package insert pages 16-17]<ref name="insert"></ref>
 
*[http://products.sanofi.us/taxotere/taxotere.pdf#page=16 Docetaxel (Taxotere) package insert pages 16-17]<ref name="insert"></ref>
 
*[http://www.uptodate.com/contents/docetaxel-patient-drug-information Docetaxel (Taxotere) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/docetaxel-patient-drug-information Docetaxel (Taxotere) patient drug information (UpToDate)]</ref>
 
*[http://www.uptodate.com/contents/docetaxel-patient-drug-information Docetaxel (Taxotere) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/docetaxel-patient-drug-information Docetaxel (Taxotere) patient drug information (UpToDate)]</ref>
 +
 +
==History of changes in FDA indication==
 +
*5/14/1996: Initial FDA approval for treatment of patients with locally advanced or metastatic [[Breast cancer | breast cancer]] who have progressed during [http://hemonc.org/wiki/Category:Anthracyclines anthracycline-based] therapy or have relapsed during [http://hemonc.org/wiki/Category:Anthracyclines anthracycline-based] adjuvant therapy.
 +
*6/22/1998: Breast cancer indication revised for the treatment of patients with locally advanced or metastatic [[Breast cancer | breast cancer]] after failure of prior chemotherapy.
 +
*12/23/1999: Label expanded to include treatment of patients with locally advanced or metastatic [[Non-small cell lung cancer | non-small cell lung cancer]] after failure of prior [http://hemonc.org/wiki/Category:Platinum_agents | platinum-based] chemotherapy.
 +
*11/27/2002: Lung cancer indication revised:
 +
** As a single agent, is indicated for the treatment of patients with locally advanced or metastatic [[Non-small cell lung cancer | non-small cell lung cancer]] after failure of prior [http://hemonc.org/wiki/Category:Platinum_agents | platinum-based] chemotherapy.
 +
** In combination with [[Cisplatin (Platinol) | cisplatin]] is indicated for the treatment of patients with unresectable, locally advanced or metastatic [[Non-small cell lung cancer | non-small cell lung cancer]] who have not previously received chemotherapy for this condition.
 +
*5/19/2004: Label expanded as follows: in combination with [[Prednisone (Sterapred) | prednisone]] is indicated for the treatment of patients with androgen independent (hormone refractory) metastatic [[Prostate cancer | prostate cancer]].
 +
*8/18/2004: Breast cancer indication expanded: in combination with [[Doxorubicin (Adriamycin) | doxorubicin]] and [[Cyclophosphamide (Cytoxan) | cyclophosphamide]] is indicated for the adjuvant treatment of patients with operable node-positive [[Breast cancer | breast cancer]].
 +
*3/22/2006: Label expanded as follows: in combination with [[Cisplatin (Platinol) | cisplatin]] and [[Fluorouracil (5-FU) | fluorouracil]] is indicated for the treatment of patients with advanced [[Gastric cancer | gastric adenocarcinoma]], including adenocarcinoma of the gastroesophageal junction, who have not received prior chemotherapy for advanced disease.
 +
*10/17/2006: Label expanded as follows: in combination with [[Cisplatin (Platinol) | cisplatin]] and [[Fluorouracil (5-FU) | fluorouracil]] is indicated for the induction treatment of patients with inoperable locally advanced [[Head and neck cancer | squamous cell carcinoma of the head and neck (SCCHN)]].
  
 
==Also known as==
 
==Also known as==
−
Asodocel, Docetax, Docetaxel Comp, Docetaxel Delta Farma, Docetaxel Microsules, Docetaxel Sandoz, Docetere, Dolectran, Doxel, Doxetal, Oncodocel, Plustaxano, N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl Taxol, Neocel, NSC 628503, RP 56976, Taxotere Aventis, Taxotere Chugai, Texot, Trixotene.
+
{| border="1" style="text-align:center;"
 +
!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
 +
|-
 +
|Asodocel
 +
|Docetax
 +
|Docetaxel Comp
 +
|Docetaxel Delta Farma
 +
|Docetaxel Microsules
 +
|-
 +
|Docetaxel Sandoz
 +
|Docetere
 +
|Dolectran
 +
|Doxel
 +
|Doxetal
 +
|-
 +
|Oncodocel
 +
|Plustaxano
 +
|N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl Taxol
 +
|Neocel
 +
|NSC 628503
 +
|-
 +
|RP 56976
 +
|Taxotere Aventis
 +
|Taxotere Chugai
 +
|Texot
 +
|Trixotene
 +
|-
 +
|}
  
 
==References==
 
==References==
Line 29: Line 84:
 
[[Category:Cervical cancer medications]]
 
[[Category:Cervical cancer medications]]
 
[[Category:Esophageal cancer medications]]
 
[[Category:Esophageal cancer medications]]
 +
[[Category:Gastric cancer medications]]
 
[[Category:Head and neck cancer medications]]
 
[[Category:Head and neck cancer medications]]
 
[[Category:Melanoma medications]]  
 
[[Category:Melanoma medications]]  
Line 37: Line 93:
 
[[Category:Sarcoma medications]]
 
[[Category:Sarcoma medications]]
 
[[Category:Small cell lung cancer medications]]
 
[[Category:Small cell lung cancer medications]]
 +
 +
[[Category:Drugs FDA approved in 1996]]

Revision as of 14:10, 25 October 2014

General information

Class/mechanism: Taxane; disrupts normal microtubular function. Binds to free tubulin, promotes their assembly into stable microtubules, and inhibits their disassembly, which inhibits mitosis.[1][2]
Route: IV
Extravasation: irritant, rare vesicant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

Synonyms
Asodocel Docetax Docetaxel Comp Docetaxel Delta Farma Docetaxel Microsules
Docetaxel Sandoz Docetere Dolectran Doxel Doxetal
Oncodocel Plustaxano N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl Taxol Neocel NSC 628503
RP 56976 Taxotere Aventis Taxotere Chugai Texot Trixotene

References

  1. ↑ 1.0 1.1 1.2 Docetaxel (Taxotere) package insert
  2. ↑ Docetaxel (Taxotere) package insert (locally hosted backup)
  3. ↑ Docetaxel (Taxotere) patient drug information (Chemocare)
  4. ↑ Docetaxel (Taxotere) patient drug information (UpToDate)
Retrieved from "https://hemonc.org/w/index.php?title=Docetaxel_(Taxotere)&oldid=5177"