Zanubrutinib (Brukinsa)

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General information

Class/mechanism: BTK inhibitor
Route: PO
Extravasation: n/a

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is established

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Chronic lymphocytic leukemia

Mantle cell lymphoma

  • 2019-11-14: Accelerated approval for adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. (Based on BGB-3111-AU-003 & BGB-3111-206)

Marginal zone lymphoma

Waldenström macroglobulinemia

History of changes in EMA indication

  • 2021-11-22: Initial authorization

Also known as

  • Code name: BGB-3111
  • Brand name: Brukinsa