Rosai-Dorfman-Destombes disease

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Ronald S. Go, MD
Mayo Clinic
Rochester, MN
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1 variants on this page


Guidelines

Consensus guidelines

All lines of therapy

Cobimetinib monotherapy

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Regimen

Study Evidence
Diamond et al. 2019 (MSK 15-216) Pilot, <20 pts in this arm

Note: there were N=2 patients with this type of histiocytosis.

Chemotherapy

28-day cycles

References

  1. MSK 15-216: Diamond EL, Durham BH, Ulaner GA, Drill E, Buthorn J, Ki M, Bitner L, Cho H, Young RJ, Francis JH, Rampal R, Lacouture M, Brody LA, Ozkaya N, Dogan A, Rosen N, Iasonos A, Abdel-Wahab O, Hyman DM. Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. Epub 2019 Mar 13. link to original article contains verified protocol link to PMC article PubMed