|Gaurav Goyal, MD|
- 2018: Abla et al. Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease PubMed
All lines of therapy
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|Diamond et al. 2019 (MSK 15-216)||Pilot, <20 pts in this arm|
Note: there were N=2 patients with this type of histiocytosis.
- Cobimetinib (Cotellic) 60 mg PO once per day on days 1 to 21
- MSK 15-216: Diamond EL, Durham BH, Ulaner GA, Drill E, Buthorn J, Ki M, Bitner L, Cho H, Young RJ, Francis JH, Rampal R, Lacouture M, Brody LA, Ozkaya N, Dogan A, Rosen N, Iasonos A, Abdel-Wahab O, Hyman DM. Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. Epub 2019 Mar 13. link to original article contains verified protocol link to PMC article PubMed