Peginterferon alfa-2a (Pegasys)
Class/mechanism: Immune system activator; binds to human type 1 interferon, activating downstream intracellular signal transduction pathways initially mediated by the JAK/STAT pathway. Interferon α-2a activates multiple biologic effects which are not fully understood. Pegylation results in a much longer half-life compared to Interferon alfa-2a (Roferon-A).
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Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 10/16/2002: Initial FDA approval for the treatment of adults with chronic hepatitis C who have compensated liver disease and have not been previously treated with interferon alfa.
Also known as
- Brand name: Pegasys