POEMS syndrome

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Andrew J. Cowan, MD
University of Washington
Seattle, WA

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POEMS: Peripheral neuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder, and Skin changes

1 regimens on this page
1 variants on this page


Guidelines

EMN

All lines of therapy

Rd

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Rd: Revlimid (Lenalidomide) & low-dose dexamethasone

Regimen

Study Evidence
Nozza et al. 2017 Phase II, <20 pts

Chemotherapy

Supportive medications

Monthly cycles, continued until progression or excess toxicity

References

  1. Nozza A, Terenghi F, Gallia F, Adami F, Briani C, Merlini G, Giordano L, Santoro A, Nobile-Orazio E. Lenalidomide and dexamethasone in patients with POEMS syndrome: results of a prospective, open-label trial. Br J Haematol. 2017 Dec;179(5):748-755. Epub 2017 Oct 19. link to original article contains verified protocol PubMed