Trimethoprim-Sulfamethoxazole (Bactrim DS)
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General information
Class/mechanism: Sulfonamide antibiotic, combination of trimethoprim and sulfamethoxazole. Sulfamethoxazole and trimethoprim work synergistically to block two consecutive steps of nucleic acid synthesis in bacteria. Sulfamethoxazole is a competitive inhibitor of para-aminobenzoic acid (PABA) and blocks bacterial synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase, blocking the production of tetrahydrofolic acid from dihydrofolic acid.[1][2]
Route: PO, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
Also known as
- Generic names: cotrimazole, cotrimoxazole, co-trimoxazole, SMX / TMP, SMZ ( CO ), SMZ-TMP, SMZ-TMP DS, TMP-SMX, TMS
- Brand names:
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| Abacin | Abactrim | Abatrim | Abditri | Abetrim | Actrim | Aditrim | Adrenol |
| Adtrim | Aksotran | Albrotran | Albutrim | Alcorim-F | Alcot | Allibac | Altrim |
| Amazole | Amoxazol | Amtran | Amtril | Andoprim | Anitrim | Anprim | Antibac |
| Antrim | Antrimox | Apcetrim | APO-Bactotrim | APO Sulfatrim | Apotrinelax | Aptrim | Aratran |
| Ascotran | Aspen | Assepium | Atomexin | Avlotrin | B.S. | BAC-Sulfitrin | Bacfar |
| Bacidal | Bacin | Bacitran | Bacmetrin | Bacoprim | Bacotrin | Bacprotin | Bacris |
| Bacsulfaprin | Bacsultrim | Bactar | Bactazol | Bactekod | Bactelan | Bacteracin | Bacterial |
| Bacteric | Bacteriof.klebs PN | Bacterol | Bacticel | Bactide | Bactifor | Bactigram | Bactille-TS |
| Bactipront | Bactiseptol | Bactiver | Bactoprim | Bactoreduct | Bactosain | Bactostab | Bactramin |
| Bactricid | Bactricida | Bactricin | Bactrilac | Bactrim | Bactrimel | Bactrin | Bactrisan |
| Bactrium DS | Bactrizole | Bactron | Bactronil | Bactropin | Bacxal | Baczin | Baczole |
| Baklinger | Baktar | Bakton | Baktrisid DS | Balkatrin | Balkatrine | Bantizol | Basatin |
| Baserin | Batrox | Baxolex | Belfactrin | Bencole | Benectrin | Berlocid | Bestofens |
| Bethaprim | Bibakrim | Bicotrim | Bimatrim | Bioprim | Biosulten | Biotran | Biotrim |
| Biotrin | Biprim | Biseptin | Biseptol | Biseptrim | Bismoral | Bisultrim | Bitrim |
| Blexon | Boschtrim | Brifeseptol | Broncoflam | Brongenit | BS | Canprim | Caretran |
| Centrim | Chemitrim | Chemix | Chemizol | Chemoprim | Chemotran | Chemotrim | Chemotrin |
| Chemozole | Chromo-Z | Cidaprim | Cipaprim | Ciplin | Citrim | Cladon | Clinitran |
| Clonea | Clotrizol | CO-Sultrin | CO-Tasian | CO-Traisole 480 | CO-Trim-Tablinen | CO-Trimazole | CO-Trimed |
| CO-Trimoxa | CO-Trimoxazol | Cobact | Cobal ST | Cocydal | Cofatrim | Colitran | Colizole |
| Colotrim | Comax | Comazole | Combact | Combi-Methoxan | Comixco | Comox | Comoxol |
| Contrimoxazole | Coprim | Coprime | Cosat | Cosig | Costazole | Cosulf | Cotoram |
| Cotran | Cotrazen | Cotrexel | Cotri | Cotribase | Cotribene | Cotribid | Cotril |
| Cotrilin | Cotrim | Cotrimax | Cotrimaxazol | Cotrimaxazole | Cotrimel | Cotrimhexal | Cotrimol |
| Cotrimox | Cotrimoxazol | Cotrimoxin | Cotrimstada | Cotripharm | Cotrisul | Cotrixyl-L | Cotrizol |
| Cotrizole | Cots | Cozol | Cozole | Creptrim | Curaprim | Daiphen | Decatrim |
| Deotrim | Dertrin | Dhatrin | Dino-BAC | Diseptyl | Doctrim | Dosatran | Drilozole |
| Drossul | Droxol | Drylin | Dubac | Dumotrim | Duobact | Duobiocin | Duoctrin |
| DUO Septol | Duratrimet | Dutran | Dvaseptol | Dynaprim | Ectaprim | Ectrin | Editrim |
| Eduprim | Eliprim | Eroprim | Erotrim | Erphatrim | Esbesul | Escoprim | Espectrin |
| Espectroprima | Ethitrim | Eurotrim | Eusaprim | Eutrim | Exazol | Fabubac | Fakzol |
| Falprim | Fameprim | Fectrim | Fedimed | Fisat | Flatran | Flocot | Forcrim |
| Forteprim | Gamactrin | Gatrima | Genoctrin | Genoxzole | Gentrim | Genzaprim | Getrim |
| Globaxol | Gobens Trim | Graprima | Groseptol | Gunametrim | Hatrix | Helveprim | Herixina |
| Hexaprim | Hicot | Hufacid | Huma-Trimel | Ibtrim | Imcotran | Imexim | Inatrim |
| Infatrim | Infectran | Infectrim | Infectrin | Infesin | Intrafort | Introcin | Irgagen |
| Isoprim | Isotrim | Japtrim | Jasotrim | Jenamoxazol | Jestrim | Justeprim | K.B.famate |
| Kaftrim | Kathrex | Katrim | Kaytran | Kemocid | Kemoprim | Kentricid | Kepinol |
| Kindoprim | KO-Kure | Kombina | Kotazol | Kotrimoksazol | Krobactrol | L-Trim | Lacreozole |
| Lagatrim | Lapikot | Laratrim | Larprim | Lastrim | Leotrim | Leprim | Lescot |
| Letus | Lictora | Lifactrin | Lifzol | Lisaprin | Litrim | Lobact | Longasal |
| Lupectrin | Lusaprim | Lykaprim | M-Moxa | M-Trim | Macprim | Macromed | Mactran |
| Madroxin | Maktrim | Martiprim | Maxaprim | Maxiprim | Maxitrin | Maxol | Maxtrim |
| Maxzol | Mazatrim | Mebryn | Medcotrim | Mediprim | Meditran | Meditrim | Medtrim |
| Megabroncoflam | Megaset | Megatrim | Meprim | Meprotrin | Methoprim | Methotrin | Metoprim |
| Metoprin | Metoxiprim | Metrim | Metxaprim | Mexaprim | Mexazole | Mezenol | Micinovo |
| Micogyl | Microbid | Microcetim | Microdyn | Microsupos Amigdalar | Microtrim | Mikotrim | Mikrosid |
| Miratrim | Moly | Mortin | Moxadden | Moxalas | Moxatrim | Moxzole | Mukadryl |
| Myctrim | Naftran | Napatrim | Navatrim | Necorzole | Neoset | Neotrim | Netocur |
| Neuroprim | Nicotrim | Nilium | Nodilon | Nopil | Norisep | Nortrim | Nortrime |
| Notrim | Notrime | Novactil | Novidrine | Novotrimel | Novotrimox | Novotrim Plus | Novozole |
| Nucotrim | Nufaprim | Nuruzole | Octil-S | Octran | Octrim | Oecotrim | Okatrim |
| Omegtrim | Omnatrim | Omsat | Onetrim | Oradin | Orbak | Orgastran | Oribact |
| Ormoprim | Ostrin Forte | Otrim | Ottoprim | Oxaprim | Pakzole | Pantrim | Patrim |
| Pehatrim | Penetrin | Pentrin | Penzole | Pharmatrim | Pharmazol | Phartex | Pisatrina |
| Plurisul | Polibatrin | Politrim | Polytran | Pribac | Primadex | Primasul | Primasulf |
| Primatrim | Primavon | Primazol | Primazole | Primotren | Primox | Primsulfon | Primzole |
| Protrin | Pulkrin | Purbac | Qiftrim | Qiftrin | Quimio-PED | Quisulyn | Rancotrim |
| Rasat | Raseptol | Ratrim | Regtin | Rematrim | Renatrim | Resprim | Retrim |
| Rexaprim | Ribatrim | Rimazole | Rimezone | Rivoprim | Rizol | Rolprim | Roubac |
| Roxtrim | Roytrin | Salgatran | Saltrim | Sanprima | Saptrim | Satrim | Sbpa Trimeth Smeth |
| Scribcin | Seematrim | Seftrim | Selectrin | Semozol | Sepiran | Sepmax | Septabid |
| Septazol | Septazole | Septerin | Septinix | Septiolan | Septocid R + | Septoprin | Septra |
| Septran | Septrin-S | Septrin Paediatric | Servitrim | Sigaprim | Sigatrim | Silpin | Siltran |
| Sinatrim | Sinersul | Sinotrim | Sisoprim | Sistrim | Sitrim | Skytrin | Smartrim |
| Soltrim | Soptrim | Sosetran | Spectrem | Spectrim | Stan | Stopan | Strim |
| Suftrex | Sulbacta | Sulfagrand | Sulfamer | Sulfamet | Sulfamethoprim | Sulfametoxazol | Sulfaprim |
| Sulfarim | Sulfatalpin | Sulfaton | Sulfatrim | Sulfatropim | Sulfawal-T | Sulfinam | Sulfoid Trimetho |
| Sulfometh | Sulfonamide | Sulfort | Sulfotrim | Sulfotrimin | Sulftran | Sulgotri | Sulotrim |
| Sulphaprim | Sulphathoprim | Sulphatran | Sulphatrim | Sulphax | Sulphytrim Forte | Sulprim | Sulprimed |
| Sultase | Sulthrim | Sultiprim | Sultorim | Sultra | Sultrex | Sultrim | Sultrima |
| Sultrimmix | Sultrivon-F | Sultropim | Sumetoprim | Sumetrolim | Sumetrolin | Sumitran | Suntrim |
| Supim | Supracombin | Suprasulf | Suprex | Supribac | Suprim | Suprimass | Suprin |
| Suptrex | Suptrim | Sutaprim | Sutrim | Sutrisan | Suxprim | Syltrifil | Synac |
| Synastat | Synbac | Synco-Smzt | Syndal | Synermed | Synerzole | Synetra | Synotrim |
| Syntoprim | System | Tabrol | Tagremin | Teof | Terasulf | Terbosulfa | Teutrin |
| Theraprim | Therasept | Theratrim | Thoprim | Thriazol | Torrid | Tprim | Trelibec |
| Trib | Tricban | Tricomox | Tricot | Trifides | Triforam | Trihexal | Trim |
| Trima | Trimaxazole | Trimel | Trimephar | Trimeran | Trimerazin | Trimeril | Trimesol |
| Trimesul | Trimesulf | Trimeta | Trimethox | Trimetoger | Trimetop Duplo | Trimetotal | Trimetox |
| Trimetrin | Trimetsol | Trimexasol | Trimexazol | Trimexazole | Trimexole-F | Trimezol | Trimezole |
| Trimfasul | Trimidar M | Triminex | Trimocom | Trimoks | Trimosul | Trimosulfa | Trimoxavin |
| Trimoxazol | Trimoxazole-BC | Trimoxin | Trimoxis | Trimoxsul | Trimozol | Trimsul | Trimzol |
| Triphimox | Tripur | Trisep | Trisfides | Trisolak Forte | Trisolvat | Trisul | Trisulcom |
| Trisulfa | Trisulfose | Trisuprim | Trisural | Tritenk | Tritosul | Trixazol | Trixzol |
| Trizole | Tryseptolum | Tytrim | U-Prin | Ulfaprim | Ultrasept | Ultrazole | Ultrim |
| Unitran | Uprina | Urethrax | Urodown | Uroplus DS | Urtium | Utrin | Versatrim |
| Virin | Weiditrin | Wiatrim | Wiltran | Wypal | X-Trim | XA-Zole | Xazotrim |
| Xepaprim | Xerazole | Xeroprim | Yekaprim | Zactron | Zamboprim | Zantran | Zaxol |
| Zecatrim | Zeptra | Zerrprim | Zolebid | Zolmed | Zoltrijem | Zoltrim | Zultrop |