Non-small cell lung cancer, BRAF-mutated

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Amit Kulkarni, MBBS
University of Minnesota
Minneapolis, MN

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Travis Osterman, DO, MS
Vanderbilt University
Nashville, TN

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Note: these are regimens tested in biomarker-specific populations, please see the main NSCLC page for other regimens.

2 regimens on this page
2 variants on this page


Advanced or metastatic disease, first-line

Dabrafenib & Trametinib

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Regimen

FDA-recommended dose
Study Years of enrollment Evidence
Planchard et al. 2017 (BRF113928-untreated) 2014-2015 Phase II (RT)

Biomarker Eligibility Criteria

  • Biomarker: BRAF V600E

Targeted therapy

Continued indefinitely

References

  1. BRF113928: Planchard D, Smit EF, Groen HJM, Mazieres J, Besse B, Helland Å, Giannone V, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE. Dabrafenib plus trametinib in patients with previously untreated BRAF(V600E)-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial. Lancet Oncol. 2017 Oct;18(10):1307-1316. Epub 2017 Sep 11. link to original article PubMed

Advanced or metastatic disease, previously treated, BRAF inhibitor-naive

Dabrafenib & Trametinib

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Regimen

FDA-recommended dose
Study Years of enrollment Evidence
Planchard et al. 2016 (BRF113928-treated) 2013-2015 Phase II (RT)

All enrolled patients had progressed on 1 to 3 prior regimens.

Biomarker Eligibility Criteria

  • Biomarker: BRAF V600E

Targeted therapy

Continued indefinitely

References

  1. BRF113928: Planchard D, Besse B, Groen HJ, Souquet PJ, Quoix E, Baik CS, Barlesi F, Kim TM, Mazieres J, Novello S, Rigas JR, Upalawanna A, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE. Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial. Lancet Oncol. 2016 Jul;17(7):984-93. Epub 2016 Jun 6. contains verified protocol link to original article link to PMC article PubMed