Melanoma, KIT-mutated

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Elizabeth Buchbinder, MD
Dana-Farber Cancer Institute
Boston, MA

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Note: these are regimens tested in biomarker-specific populations, please see the main melanoma page for other regimens.

1 regimens on this page
2 variants on this page


Advanced or metastatic disease, TKI-naive

Imatinib monotherapy

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Variant #1, pre-planned escalation

Study Evidence
Hodi et al. 2013 (BUS255) Phase II

Biomarker eligibility criteria

  • Gene: KIT
  • Alteration: amplification and mutation
  • Acceptable methods of measurement: PCR or HPLC

Chemotherapy

  • Imatinib (Gleevec) as follows:
    • Starting dose: 400 mg PO once per day
    • Upon progression: 400 mg PO twice per day

Continued indefinitely

Variant #2

Study Evidence
Carvajal et al. 2011 Phase II

Patients had melanomas arising from mucosal, acral, and chronically sun-damaged skin with KIT mutations or amplifications.

Chemotherapy

Continued indefinitely

References

  1. Carvajal RD, Antonescu CR, Wolchok JD, Chapman PB, Roman RA, Teitcher J, Panageas KS, Busam KJ, Chmielowski B, Lutzky J, Pavlick AC, Fusco A, Cane L, Takebe N, Vemula S, Bouvier N, Bastian BC, Schwartz GK. KIT as a therapeutic target in metastatic melanoma. JAMA. 2011 Jun 8;305(22):2327-34. contains protocol link to PMC article PubMed
  2. BUS255: Hodi FS, Corless CL, Giobbie-Hurder A, Fletcher JA, Zhu M, Marino-Enriquez A, Friedlander P, Gonzalez R, Weber JS, Gajewski TF, O'Day SJ, Kim KB, Lawrence D, Flaherty KT, Luke JJ, Collichio FA, Ernstoff MS, Heinrich MC, Beadling C, Zukotynski KA, Yap JT, Van den Abbeele AD, Demetri GD, Fisher DE. Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal, Acral, and Chronically Sun-Damaged Skin. J Clin Oncol. 2013 Sep 10;31(26):3182-90. Epub 2013 Jun 17. link to original article contains verified protocol link to PMC article PubMed