Juvenile myelomonocytic leukemia
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| Section editor | |
|---|---|
 |
David Noyd, MD, MPH University of Washington Seattle, WA, USA |
1 regimens on this page
1 variants on this page
|
First-line therapy
Azacitidine monotherapy
Regimen
| Study | Dates of enrollment | Evidence |
|---|---|---|
| Niemeyer et al. 2021 (AZA-JMML-001) | 2015-2017 | Phase 2, fewer than 20 pts (RT) |
Chemotherapy
- Azacitidine (Vidaza) by the following age- and weight-based criteria:
- Less than 10 kg or younger than 1 year old: 2.5 mg/kg IV over 10 to 40 minutes once per day on days 1 to 7
- 10 kg or more and 1 year old or older: 75 mg/m2 IV once per day on days 1 to 7
28-day cycle for 3 to 6 cycles
References
- AZA-JMML-001: Niemeyer CM, Flotho C, Lipka DB, Starý J, Rössig C, Baruchel A, Klingebiel T, Micalizzi C, Michel G, Nysom K, Rives S, Schmugge Liner M, Zecca M, Schönung M, Baumann I, Nöllke P, Benettaib B, Biserna N, Poon J, Simcock M, Patturajan M, Menezes D, Gaudy A, van den Heuvel-Eibrink MM, Locatelli F. Response to upfront azacitidine in juvenile myelomonocytic leukemia in the AZA-JMML-001 trial. Blood Adv. 2021 Jul 27;5(14):2901-2908. link to original article link to PMC article contains dosing details in manuscript PubMed NCT02447666