Dapsone (Aczone)

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General information

Class/mechanism: Antibacterial, inhibits bacterial synthesis of dihydrofolic acid, via competition with para-aminobenzoate for the active site of dihydropteroate synthetase.
Route: PO
Extravasation: N/A

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

No known antineoplastic properties. Used as an alternative to Trimethoprim/Sulfamethoxazole (Bactrim DS) or Pentamidine (Nebupent) for PCP/PJP prophylaxis.

Also known as

  • Brand name: Aczone