Pentamidine (Nebupent)

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General information

Class/mechanism: Antifungal, known to have activity against Pneumocystis jiroveci. Mechanism not fully understood, but mechanism hypothesized to involve inhibition of DNA, RNA, phospholipid, and protein synthesis.[1][2]
Route: inhaled, IM, IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

Also known as

  • Generic name: pentamidine dimesilate
  • Brand names: Benambax, Lomidine, Nebupent, Pentam, Pentamidina, Pneumopent

References

  1. 1.0 1.1 Pentamidine (Nebupent) package insert
  2. Pentamidine (Nebupent) package insert (locally hosted backup)
  3. Pentamidine (Nebupent) patient drug information (UpToDate)