Breast cancer, PIK3CA-mutated

From HemOnc.org - A Hematology Oncology Wiki
Jump to: navigation, search
Section editor
Fernandes Hermina WEB160x200.jpg
Hermina Fernandes, MD, FACP
University of North Dakota
Bismarck, ND
1 regimens on this page
1 variants on this page

Note: this page has regimens which are specific to breast cancer that is PIK3CA-mutated. Please see the main breast cancer page for other chemotherapy regimens.


Advanced or metastatic disease, all lines of therapy

Alpelisib & Fulvestrant

back to top

Regimen

FDA-recommended dose
Study Evidence Comparator Comparative Efficacy
André et al. 2019 (SOLAR-1) Phase III (E-RT-esc) Fulvestrant Superior PFS

Note: patients enrolled in this trial had HR-positive breast cancer.

Chemotherapy

Hormonotherapy

  • Fulvestrant (Faslodex) as follows:
    • Cycle 1: 500 mg IM once per day on days 1 & 15
    • Cycle 2 onwards: 500 mg IM once on day 1

28-day cycles

References

  1. SOLAR-1: André F, Ciruelos E, Rubovszky G, Campone M, Loibl S, Rugo HS, Iwata H, Conte P, Mayer IA, Kaufman B, Yamashita T, Lu YS, Inoue K, Takahashi M, Pápai Z, Longin AS, Mills D, Wilke C, Hirawat S, Juric D; SOLAR-1 Study Group. Alpelisib for PIK3CA-mutated, hormone receptor-positive advanced breast cancer. N Engl J Med. 2019 May 16;380(20):1929-1940. link to original article contains verified protocol PubMed