Alvocidib (Flavopiridol)

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Mechanism of action

From the NCI Drug Dictionary: A synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis.
Route: PO

Diseases for which it is used

History of changes in FDA indication

Also known as

  • Code names: HMR 1275, L-868275