Non-small cell lung cancer, ROS1-positive

From HemOnc.org - A Hematology Oncology Wiki
Revision as of 22:28, 14 January 2018 by Jwarner (talk | contribs) (Created page with "{|style="width: 100%; border-left:solid 20px #dc143c;border-right:solid 20px #dc143c;border-top:solid 20px #dc143c;border-bottom:solid 20px #dc143c;" align="center" | <span s...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

 Hello!
 We're happy that you've chosen to use HemOnc.org, and hope that you will return often. From now until January 31, we are conducting a survey to learn more about our users and how we can make the site better and more useful.
 Please help us by filling it out!
 Link: http://j.mp/2BlBaoQ


Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer. If this is your first time visiting, we suggest you read the tutorial.

Is there a regimen missing from this list? Would you like to share a different dosage/schedule or an additional reference for a regimen? Have you noticed an error? Do you have an idea that will help the site grow to better meet your needs and the needs of many others? You are invited to contribute to the site.

Section editor
TravisOsterman.jpg
 Travis Osterman, DO, MS
Nashville, TN
Twitter: TravisOsterman
LinkedIn

Note: these are biomarker-specific regimens, please see the main NSCLC page for other regimens.

6 regimens on this page
8 variants on this page


Advanced or metastatic disease, ROS1 inhibitor-naive

Crizotinib monotherapy

back to top

Regimen

Study Evidence Efficacy
Shaw et al. 2014 Phase I, >20 pts ORR: 72% (95% CI, 58-84)

Chemotherapy

28-day cycles

References

  1. Shaw AT, Ou SH, Bang YJ, Camidge DR, Solomon BJ, Salgia R, Riely GJ, Varella-Garcia M, Shapiro GI, Costa DB, Doebele RC, Le LP, Zheng Z, Tan W, Stephenson P, Shreeve SM, Tye LM, Christensen JG, Wilner KD, Clark JW, Iafrate AJ. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med. 2014 Nov 20;371(21):1963-71. Epub 2014 Sep 27. link to original article link to PMC article contains verified protocol PubMed
Retrieved from "https://hemonc.org/w/index.php?title=Non-small_cell_lung_cancer,_ROS1-positive&oldid=22725"