Non-small cell lung cancer, BRAF-mutated
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Note: these are biomarker-specific regimens, please see the main NSCLC page for other regimens.
3 regimens on this page
3 variants on this page
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Advanced or metastatic disease, BRAF inhibitor-naive
Dabrafenib & Trametinib
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Regimen
| Study | Evidence |
|---|---|
| Planchard et al. 2016 (BRF113928) | Phase II |
All enrolled patients had BRAF p.V600E mutations and had progressed on 1 to 3 prior regimens.
Chemotherapy
- Dabrafenib (Tafinlar) 150 mg PO BID
- Trametinib (Mekinist) 2 mg PO once per day
Continued until progression
References
- Planchard D, Besse B, Groen HJ, Souquet PJ, Quoix E, Baik CS, Barlesi F, Kim TM, Mazieres J, Novello S, Rigas JR, Upalawanna A, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE. Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial. Lancet Oncol. 2016 Jul;17(7):984-93. Epub 2016 Jun 6. contains verified protocol link to PMC article PubMed
- Planchard D, Smit EF, Groen HJM, Mazieres J, Besse B, Helland Å, Giannone V, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE. Dabrafenib plus trametinib in patients with previously untreated BRAF(V600E)-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial. Lancet Oncol. 2017 Oct;18(10):1307-1316. Epub 2017 Sep 11. link to original article PubMed