CNS melanoma
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| Section editors | |||
|---|---|---|---|
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Seema Nagpal, MD Palo Alto, CA |
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Elizabeth Buchbinder, MD Boston, MA |
5 regimens on this page
5 variants on this page
|
Guidelines
NCCN
All lines of therapy
Ipilimumab & Nivolumab
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Regimen
| Study | Evidence | Comparator |
|---|---|---|
| Long et al. 2018 (ANZMTG 01.14) | Randomized Phase II | Nivolumab |
Immunotherapy, part 1
- Ipilimumab (Yervoy) 1 mg/kg IV once on day 1
- Nivolumab (Opdivo) 3 mg/kg IV once on day 1
21-day cycle for 4 cycles, followed by:
Immunotherapy, part 2
- Nivolumab (Opdivo) 3 mg/kg IV over 60 minutes once on day 1
14-day cycles
References
- ANZMTG 01.14: Long GV, Atkinson V, Lo S, Sandhu S, Guminski AD, Brown MP, Wilmott JS, Edwards J, Gonzalez M, Scolyer RA, Menzies AM, McArthur GA. Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study. Lancet Oncol. 2018 Mar 27. [Epub ahead of print] link to original article PubMed