Mesna (Mesnex)
General information
Class/mechanism: Detoxifying agent to reduce the risk of hemorrhagic cystitis with agents such as Ifosfamide (Ifex). Mesna is rapidly metabolized to mesna disulfide (dimesna), which remains intravascular and is rapidly processed by the kidneys, where it is converted back into mesna. Mesna binds to the urotoxic metabolites of ifosfamide, acrolein and 4-hydroxy-ifosfamide, limiting the risk of hemorrhagic cystitis. It has not been shown to interfere with antitumor efficacy.[1][2]
Route: IV, PO
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute lymphocytic leukemia
- Bone cancer
- Cervical cancer
- Hodgkin lymphoma
- Non-Hodgkin lymphoma
- Testicular cancer
- Thymoma
- Uterine cancer
Patient drug information
- Mesna (Mesnex) package insert PDF page 14-16[1]
- Mesna (Mesnex) patient drug information (Chemocare)[3]
- Mesna (Mesnex) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 12/30/1988: Initial FDA approval:
Also known as
Precise Name: Mesna (RXCUI 44)
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| Anti Uron | MEI AN | Mesa | Mesna-Cell | Mesna Delta Farma | Mesna Filaxis | Mesna GI Kendrick | Mesna Microsules |
| Mesnex | Mesnil | Mestian | Mistabron | Mistabronco | Mitexan | Mucolene | Neper |
| Novacarel | Siruta | Uromes | Uromitexan | Uroprot | Varimesna | ||