Difference between revisions of "Ifosfamide (Ifex)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
| − | |||
*[[Bone cancer]] | *[[Bone cancer]] | ||
| + | *[[Burkitt lymphoma]] | ||
*[[CNS lymphoma]] | *[[CNS lymphoma]] | ||
*[[Cervical cancer]] | *[[Cervical cancer]] | ||
| + | *[[Diffuse large B-cell lymphoma]] | ||
| + | *[[Extranodal NK/T-cell lymphoma, nasal type]] | ||
*[[HIV-associated lymphoma]] | *[[HIV-associated lymphoma]] | ||
*[[Hodgkin lymphoma]] | *[[Hodgkin lymphoma]] | ||
| + | *[[NK/T-cell lymphoma]] | ||
*[[Penile cancer]] | *[[Penile cancer]] | ||
*[[Sarcoma]] | *[[Sarcoma]] | ||
*[[Small cell lung cancer]] | *[[Small cell lung cancer]] | ||
| − | |||
*[[Testicular cancer]] | *[[Testicular cancer]] | ||
*[[Thymoma]] | *[[Thymoma]] | ||
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[[Category:Nitrogen mustards]] | [[Category:Nitrogen mustards]] | ||
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[[Category:Bone cancer medications]] | [[Category:Bone cancer medications]] | ||
| + | [[Category:Burkitt lymphoma medications]] | ||
[[Category:Central nervous system (CNS) lymphoma medications]] | [[Category:Central nervous system (CNS) lymphoma medications]] | ||
[[Category:Cervical cancer medications]] | [[Category:Cervical cancer medications]] | ||
| + | [[Category:Diffuse large B-cell lymphoma medications]] | ||
| + | [[Category:Extranodal NK/T-cell lymphoma, nasal type medications]] | ||
[[Category:HIV-associated lymphoma medications]] | [[Category:HIV-associated lymphoma medications]] | ||
[[Category:Hodgkin lymphoma medications]] | [[Category:Hodgkin lymphoma medications]] | ||
| + | [[Category:NK/T-cell lymphoma medications]] | ||
[[Category:Penile cancer medications]] | [[Category:Penile cancer medications]] | ||
[[Category:Sarcoma medications]] | [[Category:Sarcoma medications]] | ||
[[Category:Small cell lung cancer medications]] | [[Category:Small cell lung cancer medications]] | ||
| − | |||
[[Category:Testicular cancer medications]] | [[Category:Testicular cancer medications]] | ||
[[Category:Thymoma medications]] | [[Category:Thymoma medications]] | ||
Revision as of 00:56, 13 May 2015
General information
Class/mechanism: Nitrogen mustard, alkylator. Metabolites of ifosfamide interact with DNA to produce phosphotriesters and formation of DNA cross-links. Ifosfamide requires metabolic activation by microsomal liver enzymes to form its active metabolites.[1][2]
Route: IV
Extravasation: irritant
Note: A protective agent such as Mesna (Mesnex) should be used concurrently with ifosfamide to help prevent hemorrhagic cystitis.
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Bone cancer
- Burkitt lymphoma
- CNS lymphoma
- Cervical cancer
- Diffuse large B-cell lymphoma
- Extranodal NK/T-cell lymphoma, nasal type
- HIV-associated lymphoma
- Hodgkin lymphoma
- NK/T-cell lymphoma
- Penile cancer
- Sarcoma
- Small cell lung cancer
- Testicular cancer
- Thymoma
- Uterine cancer
Patient drug information
- Ifosfamide (Ifex) patient drug information (Chemocare)[3]
- Ifosfamide (Ifex) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 12/30/1988: Initial FDA approval
Also known as
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| Alquimid | Duvaxan | Fentul | Fosfidex | Haloxan | |||
| Holoxan | Holoxane | Ifex | IFO Cell | Ifocris | |||
| Ifolem | Ifomida | Ifomide | Ifos | Ifosfamida Delta Farma | |||
| Ifosfamida Filaxis | Ifosfamida Microsules | Ifosfamida Servycal | Ifoxan | IFX | |||
| Ipamide | Isophosphamide | Isoxan | Macdafen | Mitoxana | |||
| Mitoxana Lyophilisate | PI FU Ping | Trav Ifosfamide | Tronoxal | Vero Ifosfamide | |||
References
- Drug index
- Chemotherapy
- Intravenous chemotherapy
- Irritant chemotherapy
- Nitrogen mustards
- Bone cancer medications
- Burkitt lymphoma medications
- Central nervous system (CNS) lymphoma medications
- Cervical cancer medications
- Diffuse large B-cell lymphoma medications
- Extranodal NK/T-cell lymphoma, nasal type medications
- HIV-associated lymphoma medications
- Hodgkin lymphoma medications
- NK/T-cell lymphoma medications
- Penile cancer medications
- Sarcoma medications
- Small cell lung cancer medications
- Testicular cancer medications
- Thymoma medications
- Uterine cancer medications
- Drugs FDA approved in 1988