Difference between revisions of "Leucovorin (Folinic acid)"
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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
− | ==Diseases for which it is established== | + | ==Diseases for which it is established ''(work in progress)''== |
''Note: these are diseases where folinic acid is used as an adjuvant to [[Fluorouracil (5-FU)]], as opposed to an antidote as it is used in conjunction with [[Methotrexate (MTX)]]'' | ''Note: these are diseases where folinic acid is used as an adjuvant to [[Fluorouracil (5-FU)]], as opposed to an antidote as it is used in conjunction with [[Methotrexate (MTX)]]'' | ||
*[[Colorectal cancer]] | *[[Colorectal cancer]] |
Revision as of 12:26, 26 May 2022
General information
Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of Fluorouracil (5-FU) by inhibiting thymidylate synthase.[1][2]
Route: PO, IM, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is established (work in progress)
Note: these are diseases where folinic acid is used as an adjuvant to Fluorouracil (5-FU), as opposed to an antidote as it is used in conjunction with Methotrexate (MTX)
Diseases for which it is used
Note: these are diseases where folinic acid is used as an adjuvant to Fluorouracil (5-FU), as opposed to an antidote as it is used in conjunction with Methotrexate (MTX)
- Anal cancer
- Cervical cancer
- Cholangiocarcinoma
- Esophageal cancer
- Gallbladder cancer
- Gastric cancer
- Pancreatic cancer
Diseases for which it was used
Note: these are diseases where folinic acid is used as an adjuvant to Fluorouracil (5-FU), as opposed to an antidote as it is used in conjunction with Methotrexate (MTX)
Patient drug information
- Folinic acid (Leucovorin) package insert[1]
- Folinic acid (Leucovorin) patient drug information (Chemocare)[3]
- Folinic acid (Leucovorin) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 6/20/1952: Initial FDA approval
- Indicated for use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.
Also known as
- Generic names: citrovorum factor, folinate calcium, folinato de calcio, leucovorin calcium, LV, sodium folinate
- Brand names:
Synonyms | |||||||
---|---|---|---|---|---|---|---|
Antrex | Asovorin | Biovorin | Buateron | Calcifolin | Calciumfolin | Calciumfolinat | Calcium Folinato |
Calcium Folint | Calcium Leucovorin | Calcium Leucovorn | Calcivoran | Calc Leucovorn | Calfolex | Calfolin | Calinat |
Cehafolin | Citofolin | Claro | Cromatonbic Folinico | Dalisol | Degalin | Divifolin | Durofolin |
Ecofol | Elvefocal | Emovis | Erbanfol | Estroquin | Fastovorin | Fauldleuco | Fayining |
Fedolen | Ferbon | Folaren | Folaxin | Foliben | Foli Cell | Folidan | Folidar |
Foliment | Folinac | Folinato | Folinfabra | Folinoral | Folinoxan | Folinvit | Foliplus |
Folmigor | Ifavor | Isovorin | Kalciumfolinat Perivita | Kalsiumfolinat | Kunyrin | Lederfolat | Lederfolin |
Lederfoline | Ledervorin | Legifol | Leucocalcin | Leuconolver | Leucosar | Leucovorin | Leucovorina |
Leucovorine | Leukovorin | Lovorin | Medicofolin | Medifolin | Medsavorina | Neofolin | Nyrin |
O Folin | Osfolate | Osfolato | Perfolate | Prefolic | Prevax | Recovorin | Reotan |
Rescuvolin | Resfolin | Ribofolin | Rontafor | Sanifolin | Tecnovorin | Tonofolin | Veravorin |
Vorina | Wellcovorin | Zyofolin | Zytofolin |
References
- Drugs
- Intramuscular medications
- Intravenous medications
- Oral medications
- Chemotherapy protective agents
- Anal cancer medications
- Cervical cancer medications
- Cholangiocarcinoma medications
- Colorectal cancer medications
- Colon cancer medications
- Esophageal adenocarcinoma medications
- Esophageal cancer medications
- Gallbladder cancer medications
- Gastric cancer medications
- Hepatocellular carcinoma medications
- Pancreatic cancer medications
- Rectal cancer medications
- Breast cancer medications (historic)
- FDA approved in 1952
- WHO Essential Cancer Medicine