Difference between revisions of "Non-Hodgkin lymphoma, pediatric"
m (Text replacement - "style="background-color:#1a9851" |Phase III" to "style="background-color:#1a9851" |Phase 3") |
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|[http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7720281/ Minard-Colin et al. 2020 (Inter-B-NHL Ritux 2010)] | |[http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7720281/ Minard-Colin et al. 2020 (Inter-B-NHL Ritux 2010)] | ||
|2011-2015 | |2011-2015 | ||
− | | style="background-color:#1a9851" |Phase | + | | style="background-color:#1a9851" |Phase 3 (C) |
|[[#R-COPADM|R-COPADM]] | |[[#R-COPADM|R-COPADM]] | ||
| style="background-color:#d73027" |Inferior OS | | style="background-color:#d73027" |Inferior OS | ||
Line 111: | Line 111: | ||
|[http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7720281/ Minard-Colin et al. 2020 (Inter-B-NHL Ritux 2010)] | |[http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7720281/ Minard-Colin et al. 2020 (Inter-B-NHL Ritux 2010)] | ||
|2011-2015 | |2011-2015 | ||
− | | style="background-color:#1a9851" |Phase | + | | style="background-color:#1a9851" |Phase 3 (E-RT-esc) |
|[[#COPADM|COPADM]] | |[[#COPADM|COPADM]] | ||
| style="background-color:#1a9850" |Superior OS<br>OS36: 95.1% vs 87.3%<br>(HR 0.36, 95% CI 0.16-0.82) | | style="background-color:#1a9850" |Superior OS<br>OS36: 95.1% vs 87.3%<br>(HR 0.36, 95% CI 0.16-0.82) |
Revision as of 01:57, 16 December 2021
Section editor transclusions This page contains studies that were specific to pediatric populations, who are generally treated based on risk-stratification, not on the underlying histology. See individual trials for inclusion criteria.
3 regimens on this page
3 variants on this page
|
Untreated, pre-phase
CVP
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CVP: Cyclophosphamide, Vincristine, Prednisone
COP: Cyclophosphamide, Oncovin (Vincristine), Prednisone
Regimen
Study | Years of enrollment | Evidence |
---|---|---|
Patte et al. 2007 (FAB/LMB96) | 1996-2001 | Non-randomized portion of phase 3 RCT |
Chemotherapy
- Cyclophosphamide (Cytoxan) 300 mg/m2 IV once on day 1
- Vincristine (Oncovin) 1 mg/m2 IV once on day 1
- Prednisone (Sterapred) 60 mg/m2/day IV or PO on days 1 to 7
CNS prophylaxis
- Methotrexate (MTX) (dose not specified) IT once on day 1
7-day course
Subsequent treatment
References
- FAB/LMB96: Patte C, Auperin A, Gerrard M, Michon J, Pinkerton R, Sposto R, Weston C, Raphael M, Perkins SL, McCarthy K, Cairo MS; FAB/LMB96 International Study Committee. Results of the randomized international FAB/LMB96 trial for intermediate risk B-cell non-Hodgkin lymphoma in children and adolescents: it is possible to reduce treatment for the early responding patients. Blood. 2007 Apr 1;109(7):2773-80. link to original article link to PMC article contains verified protocol PubMed NCT00002757
Untreated, induction
COPADM
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COPADM: Cyclophosphamide, Oncovin (Vincristine), Prednisone, ADriamycin (Doxorubicin), Methotrexate
Protocol
Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Patte et al. 2007 (FAB/LMB96) | 1996-2001 | Non-randomized portion of phase 3 RCT | ||
Minard-Colin et al. 2020 (Inter-B-NHL Ritux 2010) | 2011-2015 | Phase 3 (C) | R-COPADM | Inferior OS |
Note: It is not clear from Patte et al. 2007 whether the cyclophosphamide was fractionated.
Preceding treatment
Chemotherapy
- Cyclophosphamide (Cytoxan) 250 mg/m2 IV twice per day on days 2 to 4 (total dose: 1500 mg/m2)
- Vincristine (Oncovin) 2 mg/m2 IV once on day 1
- Prednisone (Sterapred) 60 mg/m2/day IV or PO on days 1 to 7
- Doxorubicin (Adriamycin) 60 mg/m2 IV once on day 2
- Methotrexate (MTX) 3000 mg/m2 IV over 3 hours once on day 1
Supportive medications
CNS prophylaxis
- Methotrexate (MTX) (dose not specified) IT once per day on days 2 & 6
One course
Subsequent treatment
- COPADM second induction; reduced-dose versus COPADM second induction; standard-dose
References
- FAB/LMB96: Patte C, Auperin A, Gerrard M, Michon J, Pinkerton R, Sposto R, Weston C, Raphael M, Perkins SL, McCarthy K, Cairo MS; FAB/LMB96 International Study Committee. Results of the randomized international FAB/LMB96 trial for intermediate risk B-cell non-Hodgkin lymphoma in children and adolescents: it is possible to reduce treatment for the early responding patients. Blood. 2007 Apr 1;109(7):2773-80. link to original article link to PMC article contains verified protocol PubMed NCT00002757
- Inter-B-NHL Ritux 2010: Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG; European Intergroup for Childhood Non-Hodgkin Lymphoma; Children’s Oncology Group. Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children. N Engl J Med. 2020 Jun 4;382(23):2207-2219. link to original article link to PMC article PubMed NCT01516580
R-COPADM
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R-COPADM: Rituximab, Cyclophosphamide, Oncovin (Vincristine), Prednisone, ADriamycin (Doxorubicin), Methotrexate
Protocol
Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Minard-Colin et al. 2020 (Inter-B-NHL Ritux 2010) | 2011-2015 | Phase 3 (E-RT-esc) | COPADM | Superior OS OS36: 95.1% vs 87.3% (HR 0.36, 95% CI 0.16-0.82) |
Note: Only partial dosing information is available in the manuscript/supplement; dosing here is primarily based on FAB/LMB96.
Preceding treatment
Targeted therapy
- Rituximab (Rituxan) 375 mg/m2 IV once per day on days -2 & 1
Chemotherapy
- Cyclophosphamide (Cytoxan) 250 mg/m2 IV twice per day on days 2 to 4 (total dose: 1500 mg/m2)
- Vincristine (Oncovin) 2 mg/m2 IV once on day 1
- Prednisone (Sterapred) 60 mg/m2/day IV or PO on days 1 to 7
- Doxorubicin (Adriamycin) 60 mg/m2 IV once on day 2
- Methotrexate (MTX) 3000 mg/m2 IV over 3 hours once on day 1
Supportive medications
CNS prophylaxis
- Methotrexate (MTX) (dose not specified) IT once per day on days 2 & 6
One course
Subsequent treatment
References
- Inter-B-NHL Ritux 2010: Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, Wheatley K, Delgado RF, Alexander S, Uyttebroeck A, Bollard CM, Zsiros J, Csoka M, Kazanowska B, Chiang AK, Miles RR, Wotherspoon A, Adamson PC, Vassal G, Patte C, Gross TG; European Intergroup for Childhood Non-Hodgkin Lymphoma; Children’s Oncology Group. Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children. N Engl J Med. 2020 Jun 4;382(23):2207-2219. link to original article link to PMC article contains partial protocol PubMed NCT01516580