Difference between revisions of "Zanubrutinib (Brukinsa)"
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==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
| − | *11/14/2019: | + | ===[[Mantle cell lymphoma]]=== |
| + | *11/14/2019: Accelerated approval for adult patients with [[mantle cell lymphoma|mantle cell lymphoma (MCL)]] who have received at least one prior therapy. ''(Based on BGB-3111-206)'' | ||
| + | |||
| + | ===[[Marginal zone lymphoma]]=== | ||
| + | *9/14/2021: Accelerated approval for adult patients with relapsed or refractory [[Marginal zone lymphoma|marginal zone lymphoma (MZL)]] who have received at least one [[Regimen_classes#Anti-CD20-based_regimen|anti-CD20-based regimen]]. ''(Based on MAGNOLIA and BGB-3111-AU-003)'' | ||
| + | |||
| + | ===[[Waldenström macroglobulinemia]]=== | ||
*8/31/2021: Approved for adult patients with [[Waldenström macroglobulinemia|Waldenström’s macroglobulinemia (WM)]]. ''(Based on ASPEN)'' | *8/31/2021: Approved for adult patients with [[Waldenström macroglobulinemia|Waldenström’s macroglobulinemia (WM)]]. ''(Based on ASPEN)'' | ||
| − | |||
==Also known as== | ==Also known as== | ||
Revision as of 01:42, 12 December 2021
General information
Class/mechanism: BTK inhibitor
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.
Diseases for which it is used
- Chronic lymphocytic leukemia
- Mantle cell lymphoma
- Marginal zone lymphoma
- Waldenström macroglobulinemia
Patient drug information
History of changes in FDA indication
Mantle cell lymphoma
- 11/14/2019: Accelerated approval for adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. (Based on BGB-3111-206)
Marginal zone lymphoma
- 9/14/2021: Accelerated approval for adult patients with relapsed or refractory marginal zone lymphoma (MZL) who have received at least one anti-CD20-based regimen. (Based on MAGNOLIA and BGB-3111-AU-003)
Waldenström macroglobulinemia
- 8/31/2021: Approved for adult patients with Waldenström’s macroglobulinemia (WM). (Based on ASPEN)
Also known as
- Code name: BGB-3111
- Brand name: Brukinsa