Difference between revisions of "Vinblastine (Velban)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
*[[Bladder cancer]] | *[[Bladder cancer]] | ||
| − | |||
*Lymphoma | *Lymphoma | ||
**[[Diffuse large B-cell lymphoma]] | **[[Diffuse large B-cell lymphoma]] | ||
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*[[Kaposi sarcoma]] | *[[Kaposi sarcoma]] | ||
*[[Langerhans cell histiocytosis]] | *[[Langerhans cell histiocytosis]] | ||
| − | |||
*[[Non-small cell lung cancer]] | *[[Non-small cell lung cancer]] | ||
*Soft tissue sarcoma | *Soft tissue sarcoma | ||
**[[Desmoid tumors]] | **[[Desmoid tumors]] | ||
*[[Testicular cancer]] | *[[Testicular cancer]] | ||
| + | |||
| + | ==Diseases for which it was used== | ||
| + | *[[Breast cancer - historical|Breast cancer]] | ||
| + | *[[Head and neck cancer - historical|Head and neck cancer]] | ||
| + | *[[Melanoma - historical|Melanoma]] | ||
| + | *[[Prostate cancer - historical|Prostate cancer]] | ||
| + | *[[Renal cell carcinoma - historical|Renal cell carcinoma]] | ||
| + | *[[Small cell lung cancer - historical|Small cell lung cancer]] | ||
==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
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[[Category:Bladder cancer medications]] | [[Category:Bladder cancer medications]] | ||
| − | |||
[[Category:Desmoid tumor medications]] | [[Category:Desmoid tumor medications]] | ||
[[Category:Diffuse large B-cell lymphoma medications]] | [[Category:Diffuse large B-cell lymphoma medications]] | ||
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[[Category:Hodgkin lymphoma, nodular lymphocyte-predominant medications]] | [[Category:Hodgkin lymphoma, nodular lymphocyte-predominant medications]] | ||
[[Category:Kaposi sarcoma medications]] | [[Category:Kaposi sarcoma medications]] | ||
| − | [[Category:Langerhans cell histiocytosis | + | [[Category:Langerhans cell histiocytosis medications]] |
| − | |||
[[Category:Non-small cell lung cancer medications]] | [[Category:Non-small cell lung cancer medications]] | ||
[[Category:Testicular cancer medications]] | [[Category:Testicular cancer medications]] | ||
| + | |||
| + | [[Category:Breast cancer medications (historic)]] | ||
| + | [[Category:Head and neck cancer medications (historic)]] | ||
| + | [[Category:Melanoma medications (historic)]] | ||
| + | [[Category:Prostate cancer medications (historic)]] | ||
| + | [[Category:Renal cell carcinoma medications (historic)]] | ||
| + | [[Category:Small cell lung cancer medications (historic)]] | ||
[[Category:FDA approved in 1965]] | [[Category:FDA approved in 1965]] | ||
[[Category:WHO Essential Cancer Medicine]] | [[Category:WHO Essential Cancer Medicine]] | ||
Revision as of 02:05, 29 April 2022
General information
Class/mechanism: Vinca alkaloid, inhibits microtubule formation in the mitotic spindle, causing cell cycle arrest in metaphase.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Vinblastine (Velban) patient drug information (Chemocare)[3]
- Vinblastine (Velban) patient drug information (UpToDate)[4]
Diseases for which it is used
- Bladder cancer
- Lymphoma
- Kaposi sarcoma
- Langerhans cell histiocytosis
- Non-small cell lung cancer
- Soft tissue sarcoma
- Testicular cancer
Diseases for which it was used
- Breast cancer
- Head and neck cancer
- Melanoma
- Prostate cancer
- Renal cell carcinoma
- Small cell lung cancer
History of changes in FDA indication
11/25/1965: Initial approval
Also known as
- Generic names: chlorhexamide, vinblastine sulfate, vinblastine sulphate, vincaleukoblastine, VLB
- Brand names:
| Synonyms | ||||
|---|---|---|---|---|
| Alkaban-AQ | Blastovin | Cellblastin | Cytoblastine | Erbablas |
| Exal | Faulblastina | Lemblastine | Periblastine | Rabinefil |
| Velban | Velbastine | Velbe | Vinblasin | Vinblastin |
| Vinblastina | ||||
References
Categories:
- Drugs
- Intravenous medications
- Vesicant
- Microtubule inhibitors
- Vinca alkaloids
- Bladder cancer medications
- Desmoid tumor medications
- Diffuse large B-cell lymphoma medications
- HIV-associated lymphoma medications
- Hodgkin lymphoma medications
- Hodgkin lymphoma, nodular lymphocyte-predominant medications
- Kaposi sarcoma medications
- Langerhans cell histiocytosis medications
- Non-small cell lung cancer medications
- Testicular cancer medications
- Breast cancer medications (historic)
- Head and neck cancer medications (historic)
- Melanoma medications (historic)
- Prostate cancer medications (historic)
- Renal cell carcinoma medications (historic)
- Small cell lung cancer medications (historic)
- FDA approved in 1965
- WHO Essential Cancer Medicine