Difference between revisions of "Ifosfamide (Ifex)"

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<br>Extravasation: [[irritant]]
 
<br>Extravasation: [[irritant]]
  
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Note: A protective agent such as mesna should be used concurrently with ifosfamide to help prevent hemorrhagic cystitis.
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Note: A protective agent such as [[Mesna (Mesnex)]] should be used concurrently with ifosfamide to help prevent hemorrhagic cystitis.
  
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>  
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>  
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==Diseases for which it is used==
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*[[Aggressive Non-Hodgkin lymphoma]]
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*[[Bone cancer]]
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*[[CNS lymphoma]]
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*[[Cervical cancer]]
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*[[HIV-associated lymphoma]]
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*[[Hodgkin lymphoma]]
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*[[Penile cancer]]
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*[[Sarcoma]]
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*[[Small cell lung cancer]]
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*[[T-cell lymphoma]]
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*[[Testicular cancer]]
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*[[Thymoma]]
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*[[Uterine cancer]]
  
 
==Patient drug information==
 
==Patient drug information==
 
*[http://chemocare.com/bio/ifosfamide.asp Ifosfamide (Ifex) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/ifosfamide.asp Ifosfamide (Ifex) patient drug information (Chemocare)]</ref>
 
*[http://chemocare.com/bio/ifosfamide.asp Ifosfamide (Ifex) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/ifosfamide.asp Ifosfamide (Ifex) patient drug information (Chemocare)]</ref>
 
*[http://www.uptodate.com/contents/ifosfamide-patient-drug-information Ifosfamide (Ifex) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/ifosfamide-patient-drug-information Ifosfamide (Ifex) patient drug information (UpToDate)]</ref>
 
*[http://www.uptodate.com/contents/ifosfamide-patient-drug-information Ifosfamide (Ifex) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/ifosfamide-patient-drug-information Ifosfamide (Ifex) patient drug information (UpToDate)]</ref>
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==History of changes in FDA indication==
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* 12/30/1988: Initial FDA approval
  
 
==Also known as==
 
==Also known as==
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<references/>
 
<references/>
  
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[[Category:Drug index]]
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[[Category:Chemotherapy]]
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[[Category:Irritant chemotherapy]]
 
[[Category:Nitrogen mustards]]
 
[[Category:Nitrogen mustards]]
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[[Category:Aggressive Non-Hodgkin lymphoma medications]]
 
[[Category:Aggressive Non-Hodgkin lymphoma medications]]
 
[[Category:Bone cancer medications]]  
 
[[Category:Bone cancer medications]]  
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[[Category:Central nervous system (CNS) cancer medications]]
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[[Category:Central nervous system (CNS) lymphoma medications]]
 
[[Category:Cervical cancer medications]]
 
[[Category:Cervical cancer medications]]
 
[[Category:HIV-associated lymphoma medications]]
 
[[Category:HIV-associated lymphoma medications]]
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[[Category:Thymoma medications]]
 
[[Category:Thymoma medications]]
 
[[Category:Uterine cancer medications]]
 
[[Category:Uterine cancer medications]]
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[[Category:Drugs FDA approved in 1988]]

Revision as of 22:05, 8 November 2014

General information

Class/mechanism: Nitrogen mustard, alkylator. Metabolites of ifosfamide interact with DNA to produce phosphotriesters and formation of DNA cross-links. Ifosfamide requires metabolic activation by microsomal liver enzymes to form its active metabolites.[1][2]
Route: IV
Extravasation: irritant

Note: A protective agent such as Mesna (Mesnex) should be used concurrently with ifosfamide to help prevent hemorrhagic cystitis.

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 12/30/1988: Initial FDA approval

Also known as

Synonyms
Alquimid Duvaxan Fentul Fosfidex Haloxan
Holoxan Holoxane Ifex IFO Cell Ifocris
Ifolem Ifomida Ifomide Ifos Ifosfamida Delta Farma
Ifosfamida Filaxis Ifosfamida Microsules Ifosfamida Servycal Ifoxan IFX
Ipamide Isophosphamide Isoxan Macdafen Mitoxana
Mitoxana Lyophilisate PI FU Ping Trav Ifosfamide Tronoxal Vero Ifosfamide

References

  1. ↑ 1.0 1.1 Ifosfamide (Ifex) package insert
  2. ↑ Ifosfamide (Ifex) package insert (locally hosted backup)
  3. ↑ Ifosfamide (Ifex) patient drug information (Chemocare)
  4. ↑ Ifosfamide (Ifex) patient drug information (UpToDate)
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