Difference between revisions of "Breast cancer, PIK3CA-mutated"
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|[https://www.nejm.org/doi/full/10.1056/NEJMoa1813904 André et al. 2019 (SOLAR-1)] | |[https://www.nejm.org/doi/full/10.1056/NEJMoa1813904 André et al. 2019 (SOLAR-1)] | ||
Revision as of 17:02, 23 January 2020
3 regimens on this page
3 variants on this page
|
Note: this page has regimens which are specific to breast cancer that is PIK3CA-mutated. Please see the main breast cancer page for other chemotherapy regimens.
Advanced or metastatic disease, all lines of therapy
Alpelisib & Fulvestrant
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Regimen
| FDA-recommended dose |
| Study | Years of study | Evidence | Comparator | Comparative Efficacy |
|---|---|---|---|---|
| André et al. 2019 (SOLAR-1) | Phase III (E-RT-esc) | Fulvestrant | Superior PFS | 2015-2017 |
Note: patients enrolled in this trial had HR-positive breast cancer.
Chemotherapy
- Alpelisib (Piqray) 300 mg PO once per day
Hormonotherapy
- Fulvestrant (Faslodex) as follows:
- Cycle 1: 500 mg IM once per day on days 1 & 15
- Cycle 2 onwards: 500 mg IM once on day 1
28-day cycles
References
- SOLAR-1: André F, Ciruelos E, Rubovszky G, Campone M, Loibl S, Rugo HS, Iwata H, Conte P, Mayer IA, Kaufman B, Yamashita T, Lu YS, Inoue K, Takahashi M, Pápai Z, Longin AS, Mills D, Wilke C, Hirawat S, Juric D; SOLAR-1 Study Group. Alpelisib for PIK3CA-mutated, hormone receptor-positive advanced breast cancer. N Engl J Med. 2019 May 16;380(20):1929-1940. link to original article contains verified protocol PubMed