Difference between revisions of "Penile cancer"
Jump to navigation
Jump to search
Andrewc072 (talk | contribs) (Created page with "'''Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer.''' Is th...") |
m (updated content) |
||
| Line 11: | Line 11: | ||
===Regimen, Pagliaro et al. 2010=== | ===Regimen, Pagliaro et al. 2010=== | ||
| − | *[[Paclitaxel (Taxol)]] 175 mg/m2 IV over 3 hours on day 1 | + | *[[Paclitaxel (Taxol)]] 175 mg/m2 IV over 3 hours once on day 1 |
| − | *[[Ifosfamide (Ifex)]] | + | *[[Ifosfamide (Ifex)]] 1200 mg/m2 IV over 2 hours once per day on days 1 to 3 |
| − | *[[Cisplatin (Platinol)]] 25 mg/m2 IV over 2 hours days 1 | + | *[[Cisplatin (Platinol)]] 25 mg/m2 IV over 2 hours once per day on days 1 to 3 |
**Administered intravenously in 250 mL of normal saline containing 12.5 g of mannitol | **Administered intravenously in 250 mL of normal saline containing 12.5 g of mannitol | ||
| − | + | *[[Mesna (Mesnex)]] 400 mg/m2 IV once before each dose of ifosfamide | |
| − | *[[Mesna (Mesnex)]] 400 mg/m2 IV before each dose of ifosfamide | + | *[[Mesna (Mesnex)]] 200 mg/m2 IV given twice, at 4 and 8 hours after each dose of ifosfamide |
| − | *[[Mesna (Mesnex)]] 200 mg/m2 IV at | ||
| − | '''21 to 28 day cycles | + | '''21 to 28-day cycles x 4 cycles; "cycle was repeated on day 22 if the patient's absolute neutrophil count was at least 1,400/μL and platelet count was at least 100,000/μL"''' |
Supportive medications: | Supportive medications: | ||
| − | *[[Dexamethasone (Decadron)]] 8 mg IV 1 hour before, or 20 mg PO at | + | *After cisplatin, hydration with 3 liters of a solution of 5% dextrose, sodium chloride, potassium chloride, magnesium sulfate, and mannitol |
| − | *Diphenhydramine (Benadryl) 50 mg IV prior to paclitaxel | + | *Either [[Dexamethasone (Decadron)]] 8 mg IV once 1 hour before paclitaxel, or [[Dexamethasone (Decadron)]] 20 mg PO given twice, at 12 and 6 hours before the paclitaxel |
| − | * | + | *Diphenhydramine (Benadryl) 50 mg IV once prior to paclitaxel |
| − | **Cimetidine (Tagamet) 300 mg IV | + | *One of the following H2 blockers: |
| − | **Ranitidine (Zantac) 50 mg IV | + | **Cimetidine (Tagamet) 300 mg IV once prior to paclitaxel |
| − | **Famotidine (Pepcid) 20 mg IV | + | **Ranitidine (Zantac) 50 mg IV once prior to paclitaxel |
| + | **Famotidine (Pepcid) 20 mg IV once prior to paclitaxel | ||
*"The use of prophylactic granulocyte colony-stimulating factor was allowed but not required" | *"The use of prophylactic granulocyte colony-stimulating factor was allowed but not required" | ||
===References=== | ===References=== | ||
# Pagliaro LC, Williams DL, Daliani D, Williams MB, Osai W, Kincaid M, Wen S, Thall PF, Pettaway CA. Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol. 2010 Aug 20;28(24):3851-7. doi: 10.1200/JCO.2010.29.5477. Epub 2010 Jul 12. [http://jco.ascopubs.org/content/28/24/3851.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/20625118 PubMed] | # Pagliaro LC, Williams DL, Daliani D, Williams MB, Osai W, Kincaid M, Wen S, Thall PF, Pettaway CA. Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol. 2010 Aug 20;28(24):3851-7. doi: 10.1200/JCO.2010.29.5477. Epub 2010 Jul 12. [http://jco.ascopubs.org/content/28/24/3851.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/20625118 PubMed] | ||
Revision as of 05:34, 23 May 2013
Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer.
Is there a regimen missing from this list? Would you like to share a different dosage/schedule or an additional reference for a regimen? Have you noticed an error? Do you have an idea that will help the site grow to better meet your needs and the needs of many others? You are invited to contribute to the site.
Neoadjuvant chemotherapy
TIP
TIP: Taxol, Ifosfamide, Platinol
Regimen, Pagliaro et al. 2010
- Paclitaxel (Taxol) 175 mg/m2 IV over 3 hours once on day 1
- Ifosfamide (Ifex) 1200 mg/m2 IV over 2 hours once per day on days 1 to 3
- Cisplatin (Platinol) 25 mg/m2 IV over 2 hours once per day on days 1 to 3
- Administered intravenously in 250 mL of normal saline containing 12.5 g of mannitol
- Mesna (Mesnex) 400 mg/m2 IV once before each dose of ifosfamide
- Mesna (Mesnex) 200 mg/m2 IV given twice, at 4 and 8 hours after each dose of ifosfamide
21 to 28-day cycles x 4 cycles; "cycle was repeated on day 22 if the patient's absolute neutrophil count was at least 1,400/μL and platelet count was at least 100,000/μL"
Supportive medications:
- After cisplatin, hydration with 3 liters of a solution of 5% dextrose, sodium chloride, potassium chloride, magnesium sulfate, and mannitol
- Either Dexamethasone (Decadron) 8 mg IV once 1 hour before paclitaxel, or Dexamethasone (Decadron) 20 mg PO given twice, at 12 and 6 hours before the paclitaxel
- Diphenhydramine (Benadryl) 50 mg IV once prior to paclitaxel
- One of the following H2 blockers:
- Cimetidine (Tagamet) 300 mg IV once prior to paclitaxel
- Ranitidine (Zantac) 50 mg IV once prior to paclitaxel
- Famotidine (Pepcid) 20 mg IV once prior to paclitaxel
- "The use of prophylactic granulocyte colony-stimulating factor was allowed but not required"
References
- Pagliaro LC, Williams DL, Daliani D, Williams MB, Osai W, Kincaid M, Wen S, Thall PF, Pettaway CA. Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol. 2010 Aug 20;28(24):3851-7. doi: 10.1200/JCO.2010.29.5477. Epub 2010 Jul 12. link to original article contains verified protocol PubMed