Difference between revisions of "Leucovorin (Folinic acid)"

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m (Jwarner moved page Folinic acid (Leucovorin) to Leucovorin (Folinic acid): Alignment with INN)
 
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==General information==
 
==General information==
−
Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of [[Fluorouracil (5-FU)]] by inhibiting thymidylate synthase.<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Leucovorin_inj.pdf Folinic acid (Leucovorin) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/folinicacid.pdf Folinic acid (Leucovorin) package insert (locally hosted backup)]</ref>
+
Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of [[Fluorouracil (5-FU)]] by inhibiting thymidylate synthase.<ref name="insert">[https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208723s000lbl.pdf Leucovorin (Folinic acid) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/folinicacid.pdf Leucovorin (Folinic acid) package insert (locally hosted backup)]</ref>
 
<br>Route: PO, IM, IV
 
<br>Route: PO, IM, IV
 
<br>Extravasation: no information  
 
<br>Extravasation: no information  
  
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>  
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>  
 +
 +
==Diseases for which it is established ''(work in progress)''==
 +
''Note: these are diseases where folinic acid is used as an adjuvant to [[Fluorouracil (5-FU)]], as opposed to an antidote as it is used in conjunction with [[Methotrexate (MTX)]]''
 +
*[[Colorectal cancer]]
 +
**[[Colon cancer]]‎
 +
**[[Rectal cancer]]
 +
*[[Hepatocellular carcinoma]]
  
 
==Diseases for which it is used==
 
==Diseases for which it is used==
 
''Note: these are diseases where folinic acid is used as an adjuvant to [[Fluorouracil (5-FU)]], as opposed to an antidote as it is used in conjunction with [[Methotrexate (MTX)]]''
 
''Note: these are diseases where folinic acid is used as an adjuvant to [[Fluorouracil (5-FU)]], as opposed to an antidote as it is used in conjunction with [[Methotrexate (MTX)]]''
  
 +
*[[Anal cancer]]
 
*[[Cervical cancer]] ‎  
 
*[[Cervical cancer]] ‎  
 
*[[Cholangiocarcinoma]]
 
*[[Cholangiocarcinoma]]
−
*[[Colon cancer]] ‎
 
 
*[[Esophageal cancer]] ‎  
 
*[[Esophageal cancer]] ‎  
−
*[[Gastric cancer]] ‎
+
**[[Esophageal adenocarcinoma]]
−
*[[Hepatocellular carcinoma]] ‎  
+
*[[Gallbladder cancer]]
−
*[[Pancreatic cancer]] ‎  
+
*[[Gastric cancer]] ‎ ‎  
−
*[[Rectal cancer]] ‎
+
*[[Pancreatic cancer]] ‎ ‎
 +
 
 +
==Diseases for which it was used==
 +
''Note: these are diseases where folinic acid is used as an adjuvant to [[Fluorouracil (5-FU)]], as opposed to an antidote as it is used in conjunction with [[Methotrexate (MTX)]]''
 +
*[[Breast cancer - historical|Breast cancer]]
  
 
==Patient drug information==
 
==Patient drug information==
−
*[http://chemocare.com/bio/folinic_acid.asp Folinic acid (Leucovorin) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/folinic_acid.asp Folinic acid (Leucovorin) patient drug information (Chemocare)]</ref>
+
*[https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208723s000lbl.pdf Leucovorin (Folinic acid) package insert]<ref name="insert"></ref>
−
*[http://www.uptodate.com/contents/leucovorin-patient-drug-information Folinic acid (Leucovorin) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/leucovorin-patient-drug-information Folinic acid (Leucovorin) patient drug information (UpToDate)]</ref>
+
*[http://chemocare.com/bio/folinic_acid.asp Leucovorin (Folinic acid) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/folinic_acid.asp Leucovorin (Folinic acid) patient drug information (Chemocare)]</ref>
 +
*[http://www.uptodate.com/contents/leucovorin-patient-drug-information Leucovorin (Folinic acid) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/leucovorin-patient-drug-information Leucovorin (Folinic acid) patient drug information (UpToDate)]</ref>
  
 
==History of changes in FDA indication==
 
==History of changes in FDA indication==
−
* 6/20/1952: Initial FDA approval
+
* 1952-06-20: Initial FDA approval
−
* Indicated for use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced [[:Category:Colorectal_cancers|colorectal cancer]].
+
* Uncertain date: Indicated for use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced [[colorectal cancer]]. ''(Based on O'Connell 1989 & Poon et al. 1989)''
  
 
==Also known as==
 
==Also known as==
−
*'''Generic names:''' citrovorum factor, folinate calcium, folinato de calcio, LV, sodium folinate
+
*'''Generic names:''' calcium folinate, citrovorum factor, folinate calcium, folinato de calcio, folinic acid, leucovorin calcium, LV, sodium folinate
 
*'''Brand names:'''
 
*'''Brand names:'''
 
{| class="wikitable" style="text-align:center;"
 
{| class="wikitable" style="text-align:center;"
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|-
 
|-
 
|Calcium Folint
 
|Calcium Folint
−
|Calcium Leucovorin
 
 
|Calcium Leucovorn
 
|Calcium Leucovorn
 
|Calcivoran
 
|Calcivoran
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|Calfolin
 
|Calfolin
 
|Calinat
 
|Calinat
 +
|Cehafolin
 
|-
 
|-
−
|Cehafolin
 
 
|Citofolin
 
|Citofolin
 
|Claro
 
|Claro
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|Divifolin
 
|Divifolin
 
|Durofolin
 
|Durofolin
 +
|Ecofol
 
|-
 
|-
−
|Ecofol
 
 
|Elvefocal
 
|Elvefocal
 
|Emovis
 
|Emovis
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|Fauldleuco
 
|Fauldleuco
 
|Fayining
 
|Fayining
 +
|Fedolen
 
|-
 
|-
−
|Fedolen
 
 
|Ferbon
 
|Ferbon
 
|Folaren
 
|Folaren
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|Folidan
 
|Folidan
 
|Folidar
 
|Folidar
 +
|Foliment
 
|-
 
|-
−
|Foliment
 
 
|Folinac
 
|Folinac
 
|Folinato
 
|Folinato
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|Folinvit
 
|Folinvit
 
|Foliplus
 
|Foliplus
 +
|Folmigor
 
|-
 
|-
−
|Folmigor
 
 
|Ifavor
 
|Ifavor
 
|Isovorin
 
|Isovorin
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|Lederfolat
 
|Lederfolat
 
|Lederfolin
 
|Lederfolin
 +
|Lederfoline
 
|-
 
|-
−
|Lederfoline
 
 
|Ledervorin
 
|Ledervorin
 
|Legifol
 
|Legifol
 
|Leucocalcin
 
|Leucocalcin
 
|Leuconolver
 
|Leuconolver
−
|Leucovorin
+
|Leucosar
 
|Leucovorina
 
|Leucovorina
 
|Leucovorine
 
|Leucovorine
 +
|Leukovorin
 
|-
 
|-
−
|Leukovorin
 
 
|Lovorin
 
|Lovorin
 
|Medicofolin
 
|Medicofolin
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|Nyrin
 
|Nyrin
 
|O Folin
 
|O Folin
 +
|Osfolate
 
|-
 
|-
−
|Osfolate
 
 
|Osfolato
 
|Osfolato
 
|Perfolate
 
|Perfolate
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|Reotan
 
|Reotan
 
|Rescuvolin
 
|Rescuvolin
 +
|Resfolin
 
|-
 
|-
−
|Resfolin
 
 
|Ribofolin
 
|Ribofolin
 
|Rontafor
 
|Rontafor
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|Veravorin
 
|Veravorin
 
|Vorina
 
|Vorina
 +
|Wellcovorin
 
|-
 
|-
−
|Wellcovorin
 
 
|Zyofolin
 
|Zyofolin
 
|Zytofolin
 
|Zytofolin
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[[Category:Chemotherapy protective agents]]
 
[[Category:Chemotherapy protective agents]]
  
 +
[[Category:Folic acid analog]]
 +
 +
[[Category:Anal cancer medications]]
 
[[Category:Cervical cancer medications]]
 
[[Category:Cervical cancer medications]]
 
[[Category:Cholangiocarcinoma medications]]
 
[[Category:Cholangiocarcinoma medications]]
 +
[[Category:Colorectal cancer medications]]
 
[[Category:Colon cancer medications]]
 
[[Category:Colon cancer medications]]
 +
[[Category:Esophageal adenocarcinoma medications]]
 
[[Category:Esophageal cancer medications]]
 
[[Category:Esophageal cancer medications]]
 +
[[Category:Gallbladder cancer medications]]
 
[[Category:Gastric cancer medications]]
 
[[Category:Gastric cancer medications]]
 
[[Category:Hepatocellular carcinoma medications]]
 
[[Category:Hepatocellular carcinoma medications]]
 
[[Category:Pancreatic cancer medications]]  
 
[[Category:Pancreatic cancer medications]]  
 
[[Category:Rectal cancer medications]]
 
[[Category:Rectal cancer medications]]
 +
 +
[[Category:Breast cancer medications (historic)]]
  
 
[[Category:FDA approved in 1952]]
 
[[Category:FDA approved in 1952]]
 
[[Category:WHO Essential Cancer Medicine]]
 
[[Category:WHO Essential Cancer Medicine]]

Latest revision as of 15:22, 29 September 2023

General information

Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of Fluorouracil (5-FU) by inhibiting thymidylate synthase.[1][2]
Route: PO, IM, IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is established (work in progress)

Note: these are diseases where folinic acid is used as an adjuvant to Fluorouracil (5-FU), as opposed to an antidote as it is used in conjunction with Methotrexate (MTX)

Diseases for which it is used

Note: these are diseases where folinic acid is used as an adjuvant to Fluorouracil (5-FU), as opposed to an antidote as it is used in conjunction with Methotrexate (MTX)

Diseases for which it was used

Note: these are diseases where folinic acid is used as an adjuvant to Fluorouracil (5-FU), as opposed to an antidote as it is used in conjunction with Methotrexate (MTX)

Patient drug information

History of changes in FDA indication

  • 1952-06-20: Initial FDA approval
  • Uncertain date: Indicated for use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. (Based on O'Connell 1989 & Poon et al. 1989)

Also known as

  • Generic names: calcium folinate, citrovorum factor, folinate calcium, folinato de calcio, folinic acid, leucovorin calcium, LV, sodium folinate
  • Brand names:
Synonyms
Antrex Asovorin Biovorin Buateron Calcifolin Calciumfolin Calciumfolinat Calcium Folinato
Calcium Folint Calcium Leucovorn Calcivoran Calc Leucovorn Calfolex Calfolin Calinat Cehafolin
Citofolin Claro Cromatonbic Folinico Dalisol Degalin Divifolin Durofolin Ecofol
Elvefocal Emovis Erbanfol Estroquin Fastovorin Fauldleuco Fayining Fedolen
Ferbon Folaren Folaxin Foliben Foli Cell Folidan Folidar Foliment
Folinac Folinato Folinfabra Folinoral Folinoxan Folinvit Foliplus Folmigor
Ifavor Isovorin Kalciumfolinat Perivita Kalsiumfolinat Kunyrin Lederfolat Lederfolin Lederfoline
Ledervorin Legifol Leucocalcin Leuconolver Leucosar Leucovorina Leucovorine Leukovorin
Lovorin Medicofolin Medifolin Medsavorina Neofolin Nyrin O Folin Osfolate
Osfolato Perfolate Prefolic Prevax Recovorin Reotan Rescuvolin Resfolin
Ribofolin Rontafor Sanifolin Tecnovorin Tonofolin Veravorin Vorina Wellcovorin
Zyofolin Zytofolin

References

  1. ↑ 1.0 1.1 1.2 Leucovorin (Folinic acid) package insert
  2. ↑ Leucovorin (Folinic acid) package insert (locally hosted backup)
  3. ↑ Leucovorin (Folinic acid) patient drug information (Chemocare)
  4. ↑ Leucovorin (Folinic acid) patient drug information (UpToDate)
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