Difference between revisions of "Mitoxantrone (Novantrone)"

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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>  
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>  
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==Diseases for which it is established ''(work in progress)''==
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**[[Follicular lymphoma]]
  
 
==Diseases for which it is used==
 
==Diseases for which it is used==
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**[[B-cell lymphoma of mucosa-associated lymphoid tissue]]
 
**[[B-cell lymphoma of mucosa-associated lymphoid tissue]]
 
**[[Diffuse large B-cell lymphoma]]
 
**[[Diffuse large B-cell lymphoma]]
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**[[Follicular lymphoma]]
 
 
**[[Hodgkin lymphoma]]
 
**[[Hodgkin lymphoma]]
 
**[[Mantle cell lymphoma]]
 
**[[Mantle cell lymphoma]]

Revision as of 15:33, 31 May 2022

General information

Class/mechanism: Synthetic antineoplastic anthracenedione, intercalates into DNA, causing crosslinking and strand breaks. Mitoxantrone inhibits topoisomerase II, which helps to uncoil and repair damaged DNA. It also has been observed to interfere with RNA and has activity against resting and proliferating cells. In vitro, it has been observed to interfere with antigen presentation; inhibit B-cell, T-cell, and macrophage proliferation; and decrease secretion of interferon gamma, tumor necrosis factor-alpha (TNF-α), and interleukin-2 (IL-2).[1][2]
Route: IV
Extravasation: irritant (usually), vesicant (rare)

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is established (work in progress)

Diseases for which it is used

Diseases for which it was used

Patient drug information

History of changes in FDA indication

  • 12/23/1987: Initial FDA approval for the initial therapy of acute nonlymphocytic leukemia (ANLL) in adults. This category includes myelogenous, promyelocytic, monocytic, and erythroid acute leukemias
  • 11/13/1996: Approved in combination with corticosteroids as initial chemotherapy for the treatment of patients with pain related to advanced hormone-refractory prostate cancer.

Also known as

  • Generic name: mitozantrone
  • Brand names: Nitrol, Novantron, Novantrone

References

  1. ↑ 1.0 1.1 Mitoxantrone (Novantrone) package insert
  2. ↑ Mitoxantrone (Novantrone) package insert (locally hosted backup)
  3. ↑ Mitoxantrone (Novantrone) patient drug information (Chemocare)
  4. ↑ Mitoxantrone (Novantrone) patient drug information (UpToDate)
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